geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Initiating head development in mouse embryos: integrating signalling and transcriptional activity


, : Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology 2(3): 120030-120030

The generation of an embryonic body plan is the outcome of inductive interactions between the progenitor tissues that underpin their specification, regionalization and morphogenesis. The intercellular signalling activity driving these processes is deployed in a time- and site-specific manner, and the signal strength must be precisely controlled. Receptor and ligand functions are modulated by secreted antagonists to impose a dynamic pattern of globally controlled and locally graded signals onto the tissues of early post-implantation mouse embryo. In response to the WNT, Nodal and Bone Morphogenetic Protein (BMP) signalling cascades, the embryo acquires its body plan, which manifests as differences in the developmental fate of cells located at different positions in the anterior-posterior body axis. The initial formation of the anterior (head) structures in the mouse embryo is critically dependent on the morphogenetic activity emanating from two signalling centres that are juxtaposed with the progenitor tissues of the head. A common property of these centres is that they are the source of antagonistic factors and the hub of transcriptional activities that negatively modulate the function of WNT, Nodal and BMP signalling cascades. These events generate the scaffold of the embryonic head by the early-somite stage of development. Beyond this, additional tissue interactions continue to support the growth, regionalization, differentiation and morphogenesis required for the elaboration of the structure recognizable as the embryonic head.

US$19.90

PMID: 22754658

DOI: 10.1098/rsob.120030


Other references

Anonymous, 1972: Section II. Tree-ring chronologies and patterns of variation of annual rings. Contains 14 papers, including : The possibility of constructing extra-long tree-ring chronologies in the southern Baltic region (T.T. Bitvinskas; V.A. Dergachev; I.I. Kairaitis; R.A. Zakarka); Dendrochronological study of Picea obovata in the lowe...

Cassells, B.; Wainwright, P.; Blom, K., 1987: Heredity and alcohol-induced brain anomalies: effects of alcohol on anomalous prenatal development of the corpus callosum and anterior commissure in BALB/c and C57BL/6 mice. Using two inbred strains of mice which have similar rates of alcohol metabolism, we asked whether prenatal alcohol exposure would cause greater incidence and severity of defects in the development of two forebrain fiber tracts, the corpus callosum...

Miller R.W., 1976: Neuro blastoma a clue for laboratory research from geographic variations in frequency. Pediatric Research 10(4): 455

Fouquet, V.; Berrebi, D.; De-Lagausie, P.; Azeinfish, S.; Chalard, F.; Peuchmaur, M.; Aigrain, Y., 2006: Ileosigmoid knotting in a child - The first case report in a French girl. Ileosigmoid knotting occurs when the ileum wraps around the base of an elongated sigmoid colon. It is rare in developed countries, especially in children. The authors report the first case of ileosigmoid knotting in a Caucasian French girl.

Dkhil, M.A.; Al-Quraishy, S.; Diab, M.M.S.; Othman, M.S.; Aref, A.M.; Abdel Moneim, A.E., 2015: The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity. This study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5 mg/kg bwt/day) was intraperitoneally in...

Fernandes, A.E.; Riant, O.; Jensen, K.F.; Jonas, A.M., 2016: Molecular Engineering of Trifunctional Supported Catalysts for the Aerobic Oxidation of Alcohols. We describe a simple and general method for the preparation and molecular engineering of supported trifunctional catalysts and their application in the representative Cu/TEMPO/NMI-catalyzed aerobic oxidation of benzyl alcohol. The methodology allo...

Gesch, W., 1982: Gliederfusser als Fischparasiten. Aus dem Arbeitskreis 'Fischkrankheiten' im VDA. Aquarium (Bornheim): 16153: 133-136

Sullivan P.J.; Lai H L.; Gallucci V.F., 1990: A catch at length analysis that incorporates a stochastic model of growth. A length-structured population model, which incorporates von Bertalanffy growth, is used to describe changes in population abundance over time. The model is incorporated into a catch-at-length algorithm that uses a nonlinear least sqaures approach...

Selden, R.F.; Treco, D.; Heartlein, M.W., 2001: Vivo protein production and delivery system for gene therapy. The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes a desired (e.g., a therapeutic) product or is its...

McMinn, S., 1989: Dungeness Bird Observatory 1987. Kent Bird Report. 1987 ; 90-92 No. 36