geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization


, : Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization. Theranostics 3(1): 3-10

The α-chemokine CXCL12 (stromal derived factor-1; SDF-1) and its corresponding G(αI) protein-coupled CXCR4 receptor axis play an important role in retention of hematopoietic stem progenitor cells (HSPCs) in bone marrow (BM) stem cell niches. CXCL12 has also been identified as a strong chemoattractant for HSPCs and implicated both in homing of HSPCs to BM after transplantation and in egress of these cells from BM into peripheral blood (PB). However, since CXCL12, as a peptide, is highly susceptible to degradation by proteolytic enzymes, its real biological availability in biological fluids may be somewhat limited. In this review, we will present data demonstrating that the CXCL12-CXCR4 axis is positively modulated by innate immunity-derived several external factors, ensuring that even low (near threshold) doses of CXCL12 still exert a robust chemotactic influence on HSPCs.

US$19.90

PMID: 23382780

DOI: 10.7150/thno.4621


Other references

Takahashi, T.; Chen, X.; Landgraf, R.; Pittman, Q.J., 1997: Reduction of PGE-2 fever in near-term pregnancy Correlations with cardiovascular responses and vasopressin release in the ventral septal area. Society for Neuroscience Abstracts 23(1-2): 138

Brannon, Loyd W., 1945: Cryolite and some organic compounds to control corn earworm and the Mexican bean beetle. In the fall of 1942 an expt. was conducted at Norfolk, Va., to determine the comparative effectiveness of cryolite, pheno-thiazine, Ca salt of dinitro-o-cyclohexylphenol, and xan-thone against the corn earworm and the Mexican bean beetle on lima b...

Kustiawan, W.S.eradji, S., 1979: Some notes on natural regeneration in East Kalimantan. Tropical agriculture research series: (12) 71-74

Nosek, J.M.tt, J., 1978: First two records of Protura (Insecta) from the Dominican Republic with synopses of both species. Journal of agriculture of the University of Puerto Rico: 62 (3) 305-308

Apolo, B., W., 1981: Trees in humid tropical forage systems: an alternative in watershed management Conservation, natural resources, America.1. Simposio internacional sobre las Ciencias Forestales y su Contribucion al Desarrollo de la America Tropical: San Jose Costa Rica 11 al 17 de octubre de 1979 editado por Manuel Chavarria: 170

Watabe, S.; Hirayama, Y.; Nakaya, M.; Kakinuma, M.; Kikuchi, K.; Guo, X.F.ng; Kanoh, S.; Chaen, S.; Ooi, T., 1997: Carp expresses fast skeletal myosin isoforms with altered motor functions and structural stabilities to compensate for changes in environmental temperature. 1. Myosin and its subfragment-1 (S1) from carp acclimated to 10degreeC showed higher actin-activated Mg2+-ATPase activity and lower thermostability than their counterparts from carp acclimated to 30degreeC. Accordingly, filament velocity for the 1...

Hatase, H.; Takai, N.; Matsuzawa, Y.; Sakamoto, W.; Omuta, K.; Goto, K.; Arai, N.; Fujiwara, T., 2002: Size-related differences in feeding habitat use of adult female loggerhead turtles Caretta caretta around Japan determined by stable isotope analyses and satellite telemetry. Stable isotope analyses and satellite telemetry were used to investigate the relationship between the body size and feeding habitat of adult female loggerhead turtles Caretta caretta around Japan. A total of 149 females from 2 nesting sites, 600 k...

Logunov, Dmitri V., 1992: Definition of the spider genus Talavera , with a description of a new species. The spider genus Talavera PECKHAM and PECKHAM is defined. Morphological characters of copulatory organs and relationships of Talavera are discussed. Four new combinations (Talavera aequipes, Talavera thorelli, Talavera monticola and Talavera trivi...

Janssen, L.J.F.; Brons, P.P.T.; Schreuder, H.W.B.; Blokx, W.A.M.; Deurloo, E.E.; van den Bos, C., 2017: Image Gallery: A rare abscess-like presentation of Langerhans cell histiocytosis. British Journal of Dermatology 176(4): E33-E33

Gao, X.; Zhang, Y.; Saum, K-Uwe.; Schöttker, B.; Breitling, L.Philipp.; Brenner, H., 2016: Tobacco smoking and smoking-related DNA methylation are associated with the development of frailty among older adults. Tobacco smoking is a preventable environmental factor that contributes to a wide spectrum of age-related health outcomes; however, its association with the development of frailty is not yet well established. We examined the associations of self-re...