+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Integration of cell biology, pharmacological modeling and statistical analysis: part I: cell biology and PK/PD in the Oncology paradigm

, : Integration of cell biology, pharmacological modeling and statistical analysis: part I: cell biology and PK/PD in the Oncology paradigm. Critical Reviews in Oncology/Hematology 83(2): 153-169

The motivation of this two-part review article is to provide a comprehensive picture of cancer, cancer drugs and the detection and treatment of cancer. In order to do so, this article integrates the cell biology and biophysics of cancer as well as the modeling of preclinical Oncology drug data and statistical analysis of Oncology clinical trials data. It also discusses novel cancer diagnostic tools and standard and potential treatment options.


PMID: 22118941

DOI: 10.1016/j.critrevonc.2011.10.004

Other references

Shorr, E.; Zweifach, B.W., 1947: Hepato-renal vasotropic factors in experimental shock and renal hypertension. Transactions of the Association of American Physicians 60(1 Vol): 28-51

Kocic, B.; Kitic, D.; Brankovic, S., 2013: Dietary flavonoid intake and colorectal cancer risk: evidence from human population studies. Flavonoids are biologically active polyphenolic compounds widely distributed in plants. More than 5000 individual flavonoids have been identified, which are classified into at least 10 subgroups according to their chemical structure. Flavonoids of...

Lachter, J.; Reshef, R.; Shiller, M.; Lavy, A.; Suissa, A.; Yassin, K., 1998: Linear echoendoscopy to evaluate for CBD stones Learning from a summary of the first fifty cases. Gastroenterology 114(4 PART 2): A527, April 15

Banias, L.; Gurzu, S.; Kovacs, Z.; Bara, T.; Bara, T.; Jung, I., 2017: Nuclear maspin expression: A biomarker for budding assessment in colorectal cancer specimens. To evaluate the maspin expression in colorectal carcinomas (CRC) and its possible role in quantification of the tumor budding. The tumor budding was prospectively quantified in 49 consecutive cases of patients that underwent surgical resection for...

Nyarko, A.K.; Asare-Anane, H.; Ofosuhene, M.; Addy, M.E.; Teye, K.; Addo, P., 2003: Aqueous extract of Ocimum canum decreases levels of fasting blood glucose and free radicals and increases antiatherogenic lipid levels in mice. The basis for managing diabetes mellitus with aqueous extract of Ocimum canum Sim (Lamiaceae), in Ghana was investigated in diabetic and normoglycemic mice. In the diabetic mice, fasting blood glucose decreased by 60% compared to 10% in control mi...

Masson, S.; Marrow, B.; Kendrick, S.; Elsharkawy, A.M.; Latimer, S.; Hudson, M., 2015: An 'alcohol contract' has no significant effect on return to drinking after liver transplantation for alcoholic liver disease. Return to drinking after liver transplantation for alcoholic liver disease (ALD) remains a source of unease with varying reported rates of return to drinking and impact this has on graft function. In 2005, the UK Transplant liver advisory group re...

Deregowski, V.; Gazzerro, E.; Priest, L., 2006: Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/b-Catenin but Not Bone Morphogenetic Protein Signaling. The Journal of Biological Chemistry 281(10): 03-10

Saarloos, D.; Alfonso, H.; Giles-Corti, B.; Middleton, N.; Almeida, O.P., 2011: The built environment and depression in later life: the health in men study. This study examined the impact of built environment (BE) attributes on depression in older men to determine whether associations were independent of neighborhood composition factors and sociodemographic, psychosocial, and health factors at the ind...

Kerkvliet, J.D., 1994: Determination of the enzyme glucose oxidase in honey. A fast semi-quantitative screening procedure for glucose oxidase in honey is described. Upon dilution of 10 g honey with 40 ml water this enzyme releases hydrogen peroxide. After 1 h a commercially available peroxide test strip is dipped into the...

Dadakhodzhaev, A.D., 1972: Small injuries and its suppurative complications as a medico-economical problem. Sovetskoe Zdravookhranenie Kirgizii 4: 42-44