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Interactions of AsCy3 with cysteine-rich peptides


, : Interactions of AsCy3 with cysteine-rich peptides. Organic Letters 16(14): 3824-3827

There is great interest in fluorogenic compounds that tag biomolecules within cells. Biarsenicals are fluorogenic compounds that become fluorescent upon binding four proximal Cys thiols, a tetracysteine (Cys(4)) motif. This work details interactions between the biarsenical AsCy3 and Cys(4) peptides. Maximal affinity was observed when two Cys-Cys pairs were separated by at least 8 amino acids; the highest affinity ligand bound in the nanomolar concentration range (K(app) = 43 nM) and with a significant (3.2-fold) fluorescence enhancement.

US$19.90

PMID: 24999741

DOI: 10.1021/ol501721j


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