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Interleukin 17-producing T helper cells in alloimmunity


, : Interleukin 17-producing T helper cells in alloimmunity. Transplantation Reviews 23(1): 11-18

Interleukin (IL) 17 is a proinflammatory cytokine already known to play a defense role against microbes and a pathogenic role in a number of autoimmune diseases. Although IL-17 can be produced by a variety of cells including neutrophils, CD8+, NK, and gamma-delta T cells, the concept of IL-17-secreting CD4+ T helper cells (Th17), distinct from Th1 and Th2, recently emerged. Herein, we discuss arguments in favor of a Th17-mediated alternative pathway of allograft rejection based on clinical and experimental observations drawn from the literature. We also discuss the complex interplays among regulatory T cells and Th17 cells in the allogeneic context.

US$19.90

PMID: 19027613

DOI: 10.1016/j.trre.2008.08.007


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