+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Interleukin-1 receptor antagonist gene (IL1RN) polymorphism possibly associated to severity of rheumatic carditis in a Brazilian cohort

, : Interleukin-1 receptor antagonist gene (IL1RN) polymorphism possibly associated to severity of rheumatic carditis in a Brazilian cohort. Cytokine 49(1): 109-113

To evaluate the IL1RN polymorphism as a possible marker for Rheumatic Fever (RF) susceptibility or disease severity. The genotypes of 84 RF patients (Jones criteria) and 84 normal race-matched controls were determined through the analysis of the number of 86-bp tandem repeats in the second intron of IL1RN. The DNA was extracted from peripheral-blood leukocytes and amplified with specific primers. Clinical manifestations of RF were obtained through a standardized questionnaire and an extensive chart review. Carditis was defined as new onset cardiac murmur that was perceived by a trained physician with corresponding valvae regurgitation or stenosis on echocardiogram. Carditis was classified as severe in the presence of congestive heart failure or upon the indication for cardiac surgery. The statistical association among the genotypes, RF and its clinical variations was determined. The presence of allele 1 and the genotype A1/A1 were found less frequently among patients with severe carditis when compared to patients without this manifestation (OR=0.11, p=0.031; OR=0.092, p=0.017). Neither allele 1 nor allele 2 were associated with the presence of RF (p=0.188 and p=0.106), overall carditis (p=0.578 and p=0.767), polyarthritis (p=0.343 and p=0.313) and chorea (p=0.654 and p=0.633). In the Brazilian population, the polymorphism of the IL-1ra gene is a relevant factor for rheumatic heart disease severity.


PMID: 19822442

DOI: 10.1016/j.cyto.2009.09.003

Other references

Totel, G.L., 1974: Physiological responses to heat of resting man with impaired sweating capacity. Journal of Applied Physiology 37(3): 346-352

McKinney, J.D.; Stammer, C.H., 1969: Role of the azomethine in the dimerization of cycloserine by aldehydes. Tetrahedron 25(1): 163-173

Falholt, W.; Fabricius, J., 1956: Application of continuously recording dye colorimeter to determination of cardiac output by the dye injection method. Danish Medical Bulletin 3(2): 55-60

Benlalam, H.; Labarriere, N.; Linard, B.; Derre, L.; Diez, E.; Pandolfino, M.-Christine; Bonneville, M.; Jotereau, F., 2001: Comprehensive analysis of the frequency of recognition of melanoma-associated antigen (MAA) by CD8 melanoma infiltrating lymphocytes (TIL): Implications for immunotherapy. Fifty-nine tumor-infiltrating lymphocyte (TIL) cultures established from melanoma-invaded lymph nodes were screened for recognition of 28 melanoma-associated antigens (MAA) in association with 31 HLA molecules. Twenty-three (39%) TIL lines reacted...

Alukhanian, O.A.; Martirosian, K.G.; Aristov, D.S.; Sviatenko, I.V., 2003: The role of endoscopic ligation of the perforating veins in the treatment of chronic venous insufficiency under conditions of the one-day surgery center. The present work is concerned with the results of endoscopic ligation of the perforating veins (SEPS) in 179 patients with chronic venous insufficiency, class 4-6, performed at the one-day surgery center. In patients suffering from varicosity, SEP...

Rebuck, J.A.; Fish, D.N., 1998: Thalidomide revisited. Thalidomide has many potential uses in the treatment of HIV infections and associated complications. However, the frequent occurrence of potentially serious drug-related adverse effects, such as teratogenicity and neurotoxicity, must be considered...

Li, G.; Lou, B.S.ow; Lung, T.; Hruby, V.J., 1994: A new tandem Michael-like addition/indirect bromination reaction for the asymmetric synthesis of unusual amino acids and direct NMR investigation. Abstracts of Papers American Chemical Society 208(1-2): ORGN 254

Nash, B.A., 2006: Diverse in practice, united in purpose. Ohio Nurses Review 80(6): 3-4

Gulenko V.I., 1989: Design and analysis of algorithm of automated synchronization for a group of pneumatic emitters. Pages 25-31 1989

Park, S.; Hong, S.M.; Lee, J.E.; Sung, S.R.; Kim, S.H., 2008: Chlorpromazine attenuates pancreatic beta-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation. We investigated the effect and mechanism of exercise and chlorpromazine (CPZ), a conventional anti-psychotic drug, on beta-cell function and mass in 90% pancreatectomized (Px) male rats. The diabetic Px rats were divided into two groups, one of wh...