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Intraocular pressure in patients with neovascular age-related macular degeneration switched to aflibercept injection after previous anti-vascular endothelial growth factor treatments

, : Intraocular pressure in patients with neovascular age-related macular degeneration switched to aflibercept injection after previous anti-vascular endothelial growth factor treatments. Retina 34(11): 2161-2166

To assess for change in intraocular pressure (IOP) in neovascular age-related macular degeneration patients switched to aflibercept after receiving previous treatments of intravitreal bevacizumab or ranibizumab. This is a retrospective chart review of the first 53 patients (53 eyes) treated with at least 2 injections of 2 mg in 0.05 mL of aflibercept by March 6, 2013, after at least 2 previous injections of 0.5 mg in 0.05 mL of ranibizumab with or without previous injections of 1.25 mg in 0.05 mL of bevacizumab. The analysis was restricted to the first such sequence within each patient. The last previous anti-vascular endothelial growth factor injection before the switch to aflibercept was ranibizumab in all cases included in the study. Each person served as his or her own control. The pre-aflibercept IOP in the before state (treatment with bevacizumab or ranibizumab) was the preinjection IOP measure before dilation at the visit of the first aflibercept injection. Statistical analysis was performed using Microsoft Excel. There were 41 patients who were first treated with ranibizumab followed by aflibercept and 12 patients treated with ranibizumab and bevacizumab followed by aflibercept. For each of these sequences, IOP in the treated eye during treatment with aflibercept (the after state) was computed in 3 different ways: the first IOP, the last IOP, and the mean IOP for the period when treated with aflibercept. The pooled data showed a mean pre-aflibercept (the before state) IOP of 14.87 that decreased to a mean first IOP of 14.57, mean last IOP of 13.79, and a mean IOP of 14.14 during aflibercept treatment. The inference is based on the pooled analysis. The 95% confidence interval for the differences (after minus before) were -0.30 (-1.12 to 0.52), -1.08 (-1.83 to -0.32), and -0.73 (-1.30 to -0.17) for the first, last, and mean IOPs, respectively. The corresponding P values were 0.46 for the first, 0.006 for the last, 0.01 for the mean IOP during the aflibercept treatment period. Intraocular pressure was found to be significantly lower in patients switched to aflibercept after previous treatments with ranibizumab and/or bevacizumab. Aflibercept may have a more favorable IOP safety profile in patients previously on other anti-vascular endothelial growth factor treatments.


PMID: 25072648

DOI: 10.1097/IAE.0000000000000264

Other references

Vrugt, J.A.; ter Braak, C.J.F.; Clark, M.P.; Hyman, J.M.; Robinson, B.A., 2008: Treatment of input uncertainty in hydrologic modeling; doing hydrology backward with Markov chain Monte Carlo simulation. Water Resources Research 44

Kebriaei, P.; Morrow, J.S.; Rimm, D.L., 1993: Cloning of human cadherin associated protein alpha- catenin shows a second isoform similar to meta-vinculin. Molecular Biology of the Cell 4(SUPPL ): 102A

Collen, B.; Dulvy, N.K.; Gaston, K.J.; Gärdenfors, U.; Keith, D.A.; Punt, Aé.E.; Regan, H.M.; Böhm, M.; Hedges, S.; Seddon, M.; Butchart, S.H.M.; Hilton-Taylor, C.; Hoffmann, M.; Bachman, S.P.; Akçakaya, H.Reşit., 2016: Clarifying misconceptions of extinction risk assessment with the IUCN Red List. The identification of species at risk of extinction is a central goal of conservation. As the use of data compiled for IUCN Red List assessments expands, a number of misconceptions regarding the purpose, application and use of the IUCN Red List ca...

Khodadadeh, S., 1994: Calculation of gait parameters direct from force plate readings. Several parameters used in the assessment of pathological gait are normally determined by measurements obtained by means other than from force plate recordings. Methods are presented whereby parameters such as stride length, step length, cadence,...

Haris, P.I., 2013: Probing protein-protein interaction in biomembranes using Fourier transform infrared spectroscopy. The position, intensity and width of bands in infrared spectra that arise from vibrational modes within a protein can be used to probe protein secondary structure, amino acid side chain structure as well as protein dynamics and stability. FTIR spe...

Giraud,G.; Lebecque,A.; Amblard,C.; Bord,C.; Sulmont-Rosse,C.; Lefur,Y., 2008: Does knowledge-based economy speaks to consumers? A French case study with respect to food products. This study determines if consumer can interpret information. A consumer survey was conducted in 2007 on knowledge of food product categories, namely cheese and wine. In France where the culture of regional food is still vivid, the geographical dim...

Dakhama, A.; Lee, Y.; Balhorn, A.; Joetham, A.; Gelfand, E.W., 2007: Treatment of RSV-infected newborn mice with Anti-IgE antibody attenuates the subsequent enhancement of airway hyperresponsiveness on re-infection. Journal of Allergy and Clinical Immunology 119(1)

West, R., 1954: Some developments with low-energy gamma-ray sources. Medical & Biological Illustration 4(3): 134-140

Eshet R.; Assa S.; Laron Z., 1975: Heterogeneity of pituitary and endogenous plasma growth hormone from fetuses and from pre mature and full term new borns. Israel Journal of Medical Sciences 11(5): 521

Wierrani, F.; Fiedler, D.; Schnitzhofer, G.; Stewart, J.C.; Gharehbaghi, K.; Henry, M.; Grin, W.; Grünberger, W.; Krammer, B., 1996: A new approach to cancer therapy due to appropriate uptake and retention kinetics of meta-tetrahydroxy-phenylchlorin in a human fibroblast cell line. Studies have shown that meta-tetrahydroxy-phenylchlorin is an efficient tumor targeting agent for laser photodynamic therapy. The effectiveness of this approach for cancer treatment depends on drug concentration, incubation time and extracellular...