+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intraoperative injection of radiocolloid for sentinel node biopsy in breast cancer

, : Intraoperative injection of radiocolloid for sentinel node biopsy in breast cancer. Journal of Nuclear Medicine Technology 41(4): 263-267

Preoperative injection of radiocolloid for axillary sentinel node biopsy in breast cancer is uncomfortable for patients. This study evaluated the reliability of radiocolloid injection as determined by sentinel node identification rate and positive sentinel node biopsy rate, after the patient has been anesthetized in the operating room as compared with preoperative injection. After institutional review board approval, a retrospective cohort of patients with breast cancer who underwent sentinel node biopsy from January 2005 through December 2010 was evaluated for analysis. Patients who received intraoperative injection of radiocolloid were compared with those who received their injection preoperatively. Patients with incomplete pathologic staging or having received neoadjuvant chemotherapy were excluded. All patients received radiocolloid injections into the retroareolar tissue; some also received intradermal injection directly over the tumor. All injections contained 37 MBq (1 mCi) in 0.5 mL of filtered (0.22-μm) (99m)Tc-sulfur colloid. Over the 6-y study period there were 904 sentinel node biopsy procedures, and 165 patients were excluded from analysis. Of the 739 sentinel node biopsies that were analyzed, 647 had preoperative injection of radiocolloid and 92 had intraoperative injection. The overall sentinel lymph node identification rates were similar for the 2 groups: 93.5% for the preoperative injection group and 94.6% for the intraoperative injection group (not statistically significant). The identification rates remained comparable for both groups when analyzed by T stage of the tumor. The average number of sentinel lymph nodes removed was similar between preoperative and intraoperative injection: 2.60 and 2.70 nodes, respectively. The overall rates of positive sentinel nodes were comparable for the 2 groups: 25.6% for the preoperative injection group and 26.4% for the intraoperative injection group (not statistically significant). When analyzed by T stage, the positive sentinel node rates remained similar between the 2 groups. The sentinel lymph node identification rate of 94.6% for the intraoperative injection group was similar to other published sentinel lymph node identification rates (96%-100%). The positive sentinel lymph node rate was also comparable to that of published series. Intraoperative injection of radiocolloid for axillary sentinel node biopsy appears equivalent to preoperative injection and is a less painful experience for breast cancer patients.


PMID: 24231723

DOI: 10.2967/jnmt.113.129460

Other references

Suzuki, T.; Kim, M.; Kozuka-Hata, H.; Watanabe, M.; Oyama, M.; Tsumoto, K.; Yamamoto, T., 2011: Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination. Tob belongs to the anti-proliferative Tob/BTG protein family. The expression level of Tob family proteins is strictly regulated both transcriptionally and through post-translational modification. Ubiquitin (Ub)/proteosome-dependent degradation of...

Gasparetto, A.; Delogu, G., 1983: Ceftazidime, as a single antibiotic, in the treatment of multi-resistant Gram-negative infections in intensive care. In this study we have evaluated the efficacy and tolerance of ceftazidime used as the only antibiotic in the treatment of 19 critically ill patients, with serious infections caused by multiply resistant Gram-negative bacilli in an intensive care u...

Van Vlierberghe, P.; Ambesi-Impiombato, A.; D.K.ersmaecker, K.; Hadler, M.; Paietta, E.; Tallman, M.S.; Rowe, J.M.; Forne, C.; Rue, M.; Ferrando, A.A., 2013: Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic alterations, immunophenotypic markers, and microarray gene expression...

Couto A.A.D.; Martins J.C.S.; Mansur E.M.; Alves M.L.M.; Nascimento M.A.; Parize M.C.; Pinheiro L.A.F.; Faria C.A.C.; Victer H.J.; E.A., 1984: High dosage intravenous methylprednisone pulsotherapy a possible therapeutic tool in active rheumatic fever with severe carditis. Eight patients with active rheumatic carditis were subjected to high dose i.v. methylprednisolone (pulsotherapy) in the past 5 yr. The effect of this therapeutic approach was evaluated through clinical examination, electrocardiogram, chest X-ray,...

Kummer, W.; Fink, L.; Dvorakova, M.; Haberberger, R.; Bohle, R.M., 1998: Laser-assisted cell-picking and subsequent RT-PCR allows subtype analysis of mRNAs derived from the cholinergic gene locus in rat cardiac neurons. Journal of Physiology Paris 92(5-6): 452-453, Oct -Dec

Morris J.M., 1973: Mechanisms involved in progesterone contraception and estrogen interception. American Journal Of Obstetrics & Gynecology: 167-176

Okitsu, S.L.; Mueller, M.S.; Amacker, M.; Vogel, D.; Westerfeld, N.; Robinson, J.A.; Zurbriggen, R.; Pluschke, G., 2008: Preclinical profiling of the immunogenicity of a two-component subunit malaria vaccine candidate based on virosome technology. Presentation of synthetic peptides on immunopotentiating reconstituted influenza virosomes is a promising technology for subunit vaccine development. An optimized virosomally delivered peptide representing 5 NPNA repeats of P. falciparum circumspo...

Grodstein, F.; Stampfer, M.J., 1994: A prospective study of tooth loss and postmenopausal hormone use. American Journal of Epidemiology 139(11 SUPPL ): S3

Haye, P.A.; Marchant, S., 2008: Isolation and characterization of 11 polymerase chain reaction primers for microsatellite loci for the Chilean marine isopod Excirolana hirsuticauda. The Chilean isopod Excirolana hirsuticauda is a marine benthic brooder with wide distributional range and low potential for long-distance dispersal. Eleven microsatellite markers were developed for E. hirsuticauda using enriched libraries. Charact...

Chen Yun; H.B.gan, 1990: The application of grey system theory to the study of the losing of soil and water in southern Fujian. Geology of Fujian = Fu-chien Ti Chih = Fujian Dizhi 9(2): 139-145