+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Investigation of membrane mechanics using spring networks: application to red-blood-cell modelling

, : Investigation of membrane mechanics using spring networks: application to red-blood-cell modelling. Materials Science & Engineering. C, Materials for Biological Applications 43: 506-516

In recent years a number of red-blood-cell (RBC) models have been proposed using spring networks to represent the RBC membrane. Some results predicted by these models agree well with experimental measurements. However, the suitability of these membrane models has been questioned. The RBC membrane, like a continuum membrane, is mechanically isotropic throughout its surface, but the mechanical properties of a spring network vary on the network surface and change with deformation. In this work spring-network mechanics are investigated in large deformation for the first time via an assessment of the effect of network parameters, i.e. network mesh, spring type and surface constraint. It is found that a spring network is conditionally equivalent to a continuum membrane. In addition, spring networks are employed for RBC modelling to replicate the optical tweezers test. It is found that a spring network is sufficient for modelling the RBC membrane but strain-hardening springs are required. Moreover, the deformation profile of a spring network is presented for the first time via the degree of shear. It is found that spring-network deformation approaches continuous as the mesh density increases.


PMID: 25175243

DOI: 10.1016/j.msec.2014.07.043

Other references

Moodie, I.M.; Labadarios, D., 1997: A rapid method of monitoring the acute phase response in a rat model. The acute phase response (APR) is accompanied by major changes in micronutrient status. It is important to be able to quantitate the degree of APR, which can then be related to the accompanying alterations in micronutrient levels. A rapid and conv...

Bauldry, S.A.; Xiong, H.; Bass, D.A., 1993: Correlation between phospholipase A-2 and phospholipase D activation in permeabilized human neutrophils. Journal of Immunology 150(8 PART 2): 168A

Cooper, JE., 1989: The role of pathogens in threatened populations: an historical review. International Council for Bird Preservation Technical Publication, 51-61 No. 10

Jeekel C.A.W., 1970: Centipedes and millipeds chilopoda and diplopoda from friesland. Entomologische Berichten (Amsterdam) 30(1): 5-7

Lumsden A.; Kelly A.; Dodson T.; Kotze H.; Hanson S.; Harker L., 1990: Interruption of implanted vascular graft thrombosis by brief local therapy with d phenylalanine proline arginine chloromethylketone. Circulation 82(4 SUPPL 3): III603

Ensminger, W.D.; Tamm, I., 1971: Cellular DNA replication in viral infection. Pathobiology Annual 1: 33-61

Martin Cecilia F., 1980: Metallogeny in South America. Bulletin - Commission for the Geological Map of the World = Bulletin - Commission de la Carte Geologique du Monde 27): 37-48

Killer, H.E.; Jaggi, G.P.; Miller, N.R., 2011: Optic nerve compartment syndrome. Acta Ophthalmologica 89(5): E472; Author Reply E472-3

Vice, Daniel H., 2011: Integration of a field trip into the laboratory component of an introductory geology course. Laboratory exercises and field trips are a basic component of teaching geology but some education authorities, e.g., McKeachie et al. (1994), suggest that these methods do not reach their full potential. However, research on student learning sugge...

Reyneke, C.J.; James, M.F.; Johnson, R., 1989: Alfentanil and propofol infusions for surgery in the burned patient. We have studied combinations of alfentanil and propofol for total i.v. anaesthesia in 24 severely burned patients. No inhalation agents were used. After a loading dose of alfentanil 100 micrograms kg-1, the intraoperative requirement was 1.24 (SEM...