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Is a polymorphism in 10q25 associated with non-syndromic cleft lip with or without cleft palate? A meta-analysis based on limited evidence


, : Is a polymorphism in 10q25 associated with non-syndromic cleft lip with or without cleft palate? A meta-analysis based on limited evidence. British Journal of Oral & Maxillofacial Surgery 53(1): 8-12

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common defects in the human facial structure. A polymorphism, rs7078160 in 10q25, has been reported to be involved in susceptibility to the condition but results remain conflicting. To address this we did a meta-analysis of 7 eligible studies. Two authors independently collected information from the papers, and fixed effects or random effects models were used to calculate the combined estimates of risk. The pooled results showed that rs7078160 on 10q25, the minor allele A, had a higher risk of NSCLP than the major allele G (OR: 1.32, 95% CI: 1.18 to 1.47). Overall, the results showed that the 10q25 rs7078160 polymorphism was associated with a risk of NSCL/P.

US$19.90

PMID: 25300891

DOI: 10.1016/j.bjoms.2014.08.021


Other references

Simpson F.G.; Arnold A.G.; Purvis A.; Muers M.F.; Cooke N.J., 1985: Postal survey of medical bronchoscopies in the the uk drugs and safety precautions. Thorax 40(3): 210

Takamatsu, M.; Oki, M.; Maeda, K.; Inoue, Y.; Hirayama, H.; Yoshizuka, K., 1984: PCBs in blood of workers exposed to PCBs and their health status. Fact-finding surveys of workers occupationally exposed to polychlorinated biphenyls (PCBs) in the production of silk thread or of paint were carried out. Some of the workers showed higher PCB levels in the plasma than typical yusho patients. Gas c...

Claessens, R.A.M.J.; Boerman, O.C.; Koenders, E.B.; Oyen, W.J.G.; Corstens, F.H.M., 1993: Dissociation of indium from IgG in infectious foci. International Journal of Biological Markers 8(4): 259-260

Fuzes, K.; Osorio, V.; Lacasta, D., 2007: Bloating of rumen and abomasum in a ewe caused by caseous lymphadenitis. A case study is described of a 6-year-old Aragonese ewe with severe bloating symptoms. Postmortem examination confirmed the presence of Corynebacterium pseudotuberculosis in lymph nodes.

Kolbe, H., 1924: Ueber einige Paussidarten Australiens (Gattung Arthropterus). TijdschrThe Hague: 10-28

Pilleri, G., 1979: Taxonomic status of 'Cortesi's dolphin' (Tursiops cortesi, Keferstein, 1834) from the Lower Pliocene of northern Italy. The type specimen of T. cortesi, a fossil delphinid from the Lower Pliocene in northern Italy, was originally kept in the Milan Natural History Museum and was destroyed during the second world war. Illustrations and skull measurements are given of...

Liu, C.H.; Wang, S.Y., 2004: Ileal herniation into a sigmoid colon epiploic fat foramen extrasigmoid hernia. Internal abdominal hernia (IAH) is defined as protrusion of viscus through a peritoneal or mesenteric aperture, leading to its encapsulation within another compartment in the abdominal cavity. Herein we report a rare case of small bowel obstructio...

Seitz, J.F.; Sarradet, A.; François, E.; Jacob, J.H.; Ollivier, J.M.; Rougier, P.; Roussel, A., 2001: Carcinoma of the oesophagus. British Journal of Cancer 84 Suppl 2: 61-64

Tripodi, J.; Hoffman, R.; Najfeld, V.; Weinberg, R., 2010: Frequency of heterozygous TET2 deletions in myeloproliferative neoplasms. The Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are a group of clonal hematopoietic stem cell disorders with overlapping clinical and...

Vallersnes, O.Martin.; Persett, P.Sverre.; Øiestad, E.Leere.; Karinen, R.; Heyerdahl, F.; Hovda, K.Erik., 2017: Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway. Recreational drug toxicity is frequent. Availability of new psychoactive substances is steadily increasing. However, data with verified analyses from clinical settings are limited. To evaluate the impact of novel psychoactive substances (NPS) on r...