geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ixabepilone for the treatment of taxane-refractory breast cancer


, : Ixabepilone for the treatment of taxane-refractory breast cancer. Future Oncology 4(3): 333-340

The ephothilones are a novel class of agents that bind to beta-tubulin, promote microtubule stabilization and cause cell-cycle arrest in G2/M phase. Ixabepilone (Ixempra) is an epothilone B that has demonstrated preclinical activity against a variety of tumor types and has recently been US FDA approved (application for registration ongoing in Europe) as a single agent for the treatment of taxane-refractory metastatic breast cancer, or in combination with capecitabine for patients with advanced breast cancer refractory to anthracyclines and taxanes. This review will provide an overview of the clinical development of ixabepilone, and emphasize the drug's utility for the treatment of advanced breast cancer.

US$19.90

PMID: 18518758

DOI: 10.2217/14796694.4.3.333


Other references

Edwards, N.V., 2008: Pharmaceutical new product development: the increasing role of in-licensing. Many pharmaceutical companies are facing a pipeline gap because of the increasing economic burden and uncertainty associated with internal research and development programs designed to develop new pharmaceutical products. To fill this pipeline gap...

You, J., 2006: Significance and necessity of developing quality of life questionnaire for cancer patients adapting to traditional Chinese medicine. The clinical evaluation system for therapeutic effects of tumor, which focuses on survival period and tumor response rate, has been proved not very proper for evaluating the therapeutic effects of traditional Chinese medicine (TCM). Quality of lif...

Jindal, S.K., 1989: Absorption of proteins from immature epididymis of buffalo. The spermatocrit of caput and cauda epididymidis luminal fluid from 5 two-yr-old Murrah buffaloes averaged 6.55+or-5.28 and 23.95+or-10.09% resp. (P<0.05), and the protein concentration of the fluid 43.84+or-2.26 and 39.95+or-6.05 micro g/ micr...

Foltin, G.L., 1993: To intubate or not to intubate: that is the question. Prehospital and Disaster Medicine 9(1): 9-10

Saxena, B.; Goldstein, D.P.; Emerson, K.; Selenkow, H.A., 1968: Serum placental lactogen levels in patients with molar pregnancy and trophoblastic tumors. American Journal of Obstetrics and Gynecology 102(1): 115-121

Lin, G.; Zhao, J.; Wu, J.; Andreevich O.R.; Zhang, W-H.; Zhang, Y.; Yu, L., 2014: Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis. Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation...

Adam, Z.; Chlupová, G.; Neumann, A.; Jakubcová, B.; Simonides, J.; Adamová, Z.; König, J.; Krupa, P.; Szturz, P.; Pour, L.; Krejčí, M.; Hájek, R.; Král, Z.; Mayer, J., 2012: Teleangiectasia hereditaria haemorrhagica--Osler-Weber-Rendu syndrome. Case study and treatment experience. Hereditary haemorrhagic telangiectasy is an inborn disease with autosomal dominant transmission. Nose bleeding usually occurs during the 2nd decade of life as the first sign of the disease. Later, during the 3rd or 4th decade of life, typical subt...

Han D.; Rhee J.S., 1986: Characteristics of lipase catalyzed hydrolysis of olive oil in bis 2 ethylhexyl sodium sulfosuccinate isooctane reversed micelles. Candida rugosa lipase solubilized in organic solvents in the presence of both surfactant and water could catalyze the hydrolysis of triglycerides, and kinetic analysis of the lipase-catalyzed reaction was found to be possible in this system. Among...

Gruenwald, K.; Holland, J.Todd.; Stromberg, V.; Ahmad, A.; Watcharakichkorn, D.; Okumoto, S., 2012: Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. Glutamine plays a central role in the metabolism of critical biological molecules such as amino acids, proteins, neurotransmitters, and glutathione. Since glutamine metabolism is regulated through multiple enzymes and transporters, the cellular gl...

Gelfand M.C.; Steinberg A.D.; Paul W.E., 1974: Rapid appearance of complement receptor lymphocytes in mice having auto immune glomerulo nephritis. Kidney International 6(6): 46A