+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population

, : Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population. Molecular Vision 16(): 1771-1775

Werner syndrome is an autosomal recessive disease of premature aging caused by a polymorphic C1367T mutation in the Werner (WRN) gene. Although there are differences between the pathobiology of normal aging and the phenotype of Werner syndrome, the clinical age-related changes are similar. The aim of the study was to investigate the incidence of the C1367T (rs1346044) polymorphism in patients with age-related cataract. The study group consisted of 81 patients with senile cataract undergoing cataract extraction surgery. Data on age, sex, and medical history of microvascular disease and cancer were obtained from the medical files. Anterior lens capsule material was collected during surgery. DNA was extracted, amplified by polymerase chain reaction, and screened for the C1367T polymorphism in WRN using restriction enzymes followed by sequencing. There were 33 male and 48 female patients of mean age 74.3+/-9 years. Genotypic frequencies were 67% for TT and 33% for TC. None of the patients had the CC genotype. Ten patients had a history of myocardial infarct, 8 cerebrovascular accident, and 8 various tumors. The distribution of these morbidities was similar in the two genotype groups. The distribution of the C1367T WRN polymorphism in patients with senile cataract is similar to that in the normal population. Cataract formation in the elderly is not linked to a WRN mutation.


PMID: 20808731

Other references

Gaebel, W., 1993: The importance of non-biological factors in influencing the outcome of clinical trials. The outcome of clinical drug trials is influenced both by biological and by non-biological factors. Non-biological factors can be subdivided into methodological factors and non-drug factors. The former are related to the definition and measurement...

Wang, Q.; Chen, H-Y.; Hu, C-R.; Ting, C.S., 2006: Local tunneling spectroscopy as a signature of the Fulde-Ferrell-Larkin-Ovchinnikov state in s- and d-wave superconductors. The Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) states for two-dimensional s- and d-wave superconductors (s- and d-SCs) are self-consistently studied under an in-plane magnetic field. While the stripe solution of the order parameter is found to have l...

Corlett, M.; Corlett, M.E., 1999: Fungi Canadenses. No. 341. Alternaria linicola. Alternaria linicola on flax in Canada is described and illustrated. Details of its taxonomy and distribution in Canada are discussed.

Gil-Santana, H.R.; Zeraik, S.O.ichio., 2002: Reduviidae from Nova Friburgo, Rio de Janeiro State, Brazil Hemiptera-Heteroptera Reduviidae de Nova Friburgo, Estado do Rio de Janeiro, Brasil Hemiptera-Heteroptera. Entomologia y Vectores. Abril-maio-junho-julho; 92: 295-299

Sharma, K.; Singh, B.; Chauhan, R., 1995: An improved medium for in vitro grain development from detached wheat spikelets. Wheat spikelets detached from the spike at anthesis were cultured on solidified media and successfully produced mature grains. These grains resembled normal grains and contained well-developed, embryos. Lower concentrations of glutamine favored dr...

Trocky, N.M.; Fontinha, M., 2006: Quality management tools: facilitating clinical research data integrity by utilizing specialized reports with electronic case report forms. Data collected throughout the course of a clinical research trial must be reviewed for accuracy and completeness continually. The Oracle Clinical (OC) data management application utilized to capture clinical data facilitates data integrity through...

Schmid, W., 1986: Drittbruten der Gebirgsstelze (Motacilla cinerea) in Nordwurttemberg. Ornithologische Jahreshefte fuer Baden-Wuerttemberg, 22: 81-82

Lukaszewski A.J.; Apolinarska B.; Gustafson J.P.; Krolow K.D., 1984: Chromosome constitution of tetraploid triticale triticosecale. Among 69 tetraploid triticale lines from 3 breeding programs, 31 different chromosomal combinations were identified. There were 24 combinations with 14 wheat and 14 rye chromosomes, 6 combinations with 12 wheat and 16 rye chromosomes (where an ext...

Park, H.; Lee, S.; Heo, W.Do., 2016: Protein Inactivation by Optogenetic Trapping in Living Cells. Optogenetic modules that use genetically encoded elements to control protein function in response to light allow for precise spatiotemporal modulation of signaling pathways. As one of optical approaches, LARIAT (Light-Activated Reversible Inhibiti...

Walker R.M., 1975: Interaction of energetic nuclear particles in space with the lunar surface. Annual Review of Earth and Planetary Sciences 3: 99-128