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Late HIV diagnosis and determinants of progression to AIDS or death after HIV diagnosis among injection drug users, 33 US States, 1996-2004


, : Late HIV diagnosis and determinants of progression to AIDS or death after HIV diagnosis among injection drug users, 33 US States, 1996-2004. Plos One 4(2): E4445-E4445

The timeliness of HIV diagnosis and the initiation of antiretroviral treatment are major determinants of survival for HIV-infected people. Injection drug users (IDUs) are less likely than persons in other transmission categories to seek early HIV counseling, testing, and treatment. Our objective was to estimate the proportion of IDUs with a late HIV diagnosis (AIDS diagnosis within 12 months of HIV diagnosis) and determine the factors associated with disease progression after HIV diagnosis. Using data from 33 states with confidential name-based HIV reporting, we determined the proportion of IDUs aged >or=13 years who received a late HIV diagnosis during 1996-2004. We used standardized Kaplan-Meier survival methods to determine differences in time of progression from HIV to AIDS and death, by race/ethnicity, sex, age group, CD4(+) T-cell count, metropolitan residence, and diagnosis year. We compared the survival of IDUs with the survival of persons in other transmission categories. During 1996-2004, 42.2% (11,635) of 27,572 IDUs were diagnosed late. For IDUs, the risk for progression from HIV to AIDS 3 years after HIV diagnosis was greater for nonwhites, males and older persons. Three-year survival after HIV diagnosis was lower for IDU males (87.3%, 95% confidence interval (CI), 87.1-87.4) compared with males exposed through male-to-male sexual contact (91.6%, 95% CI, 91.6-91.7) and males exposed through high-risk heterosexual contact (HRHC) (91.9%, 95% CI, 91.8-91.9). Survival was also lower for IDU females (89.5%, 95% CI, 89.4-89.6) compared to HRHC females (93.3%, 95% CI, 93.3-93.4). A substantial proportion of IDUs living with HIV received their HIV diagnosis late. To improve survival of IDUs, HIV prevention efforts must ensure early access to HIV testing and care, as well as encourage adherence to antiretroviral treatment to slow disease progression.

US$19.90

PMID: 19214229

DOI: 10.1371/journal.pone.0004445


Other references

Larsen Byron I., 1974: Zoning of minerals lands. Pages 7 1974

Kuwayama, S., 1966: The type specimens of the Neuroptera in the collection of the Entomological Institute, Hokkaido University. Insecta Matsumurana, 28: 133-140

Kalvoda, J.; Botta, L., 1972: Novel radical-induced functional group transfer. Synthesis of 18-cyano-corticosteroids. Helvetica Chimica Acta 55(2): 356-366

Tedaldi, E.M.; Miller, N.; Tseng, J.; Van Den Berg Wolf, M.G.; Moyer, D., 1996: Surveillance of HIV antibody testing in an urban academic medical center. ELEVENTH INTERNATIONAL CONFERENCE ON AIDS [Author] Eleventh International Conference on AIDS, Vol One One world: One hope : 151

Crisler, G.R., 1953: Sprains and strains treated with the ultrafaradic M-4 impulse generator. Journal of the Florida Medical Association. Florida Medical Association 40(1): 32-34

Butturini, G.; Bassi, C.; Falconi, M.; Bonora, A.; Salvia, R.; Caldiron, E.; Sartori, N.; Valerio, A.; Contro, C.; Casetti, L.; Marcucci, S.; Pederzoli, P., 1998: Results of a prospective randomized trial on the surgical management of pancreatic stump after left resection. Digestive Surgery 15(5): 633-634

Venturella, G.; Palazzolo, E.; Saiano, F.; Gargano, M.Letizia., 2015: Notes on a New Productive Strain of King Oyster Mushroom, Pleurotus eryngii (Higher Basidiomycetes), a Prized Italian Culinary-Medicinal Mushroom. In this paper, the authors provide data on a culinary-medicinal, host-specific variety of P. eryngii species-complex that is known in Italy as "cardoncello". A species description, the techniques of isolation of a new strain (C-142-c), a...

Romeiko, I.M.; Bityukova, L.B.; Zil, L.M.; Kucherenko, V.I., 1976: Comparative characteristic of methods for detecting phyto toxic properties of soil microorganisms. Bacteria were isolated from different genetic horizons of the soddy podzolic soil and from the rhizosphere of winter wheat and maize grown on deep chernozem. Mass isolation of inhibitor bacteria was done to determine optimal conditions under which...

Kishi, H.O.umoto, C.H.raoka, E., 1971: Isolation and properties of mutants of Lactobacillus fermenti resistant to amprolium. Journal of vitaminology: 0, 17 (2) 59-63

Ichinose, K.; Nakamura, M.; Takezawa, K.; Masutomi, I.; Shima, Y.; Hirayama, Y.; Sorimachi, K.; Shimizu, T.; Ishikawa, H.; Kaji, N.; Nakajima, S.; Wataru, M.; Nishigaki, S.; Suwa, H.; Toyama, Y.; Okumura, M.; Ishitsuka, Y.; Shimizu, K.; Kokubo, K.; Sasaki, K.; Saito, S., 2006: Life-long education of a specialists is possible only through daily activities as clinical instructors being evaluated by interns and mutual efforts for advancement. Seishin Shinkeigaku Zasshi 108(9): 945-954