+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Left atrial diameter and albumin with renal outcomes in chronic kidney disease

, : Left atrial diameter and albumin with renal outcomes in chronic kidney disease. International Journal of Medical Sciences 10(5): 575-584

Echocardiographic left atrial diameter (LAD) has been documented to be an independent predictor of adverse cardiovascular outcomes in various populations. An enlarged left atrium is frequently noted in chronic kidney disease (CKD). We examined the association between albumin and indexed LAD (indexed to height) and assessed whether the combination of indexed LAD and albumin was independently associated with renal outcomes in patients with CKD stages 3-5. This longitudinal study enrolled 395 patients, who were classified into four groups according to median values of indexed LAD (LAD/height) and albumin. The change in renal function was measured by estimated glomerular filtration rate (eGFR) slope. Rapid renal progression was defined as eGFR slope less than -3 ml/min/1.73 m(2)/year. The renal end point was defined as commencement of dialysis. Albumin was significantly associated with indexed LAD (β = -0.108, P = 0.024). During follow-up period, seventy-four patients started dialysis. After the multivariate analysis, the group with higher indexed LAD and lower albumin was independently associated with rapid renal progression (odds ratio, 7.979; 95% confidence interval [CI], 3.028 to 21.025) and progression to dialysis (hazard ratio, 2.352; 95% CI, 1.078 to 5.131). Our findings show that albumin is independently associated with indexed LAD and suggest that the combination of increased indexed LAD and hypoalbuminemia is independently associated with rapid renal progression and progression to dialysis in patients with CKD. Assessments of serum albumin and indexed LAD by echocardiography are useful for predicting the risk for adverse renal outcomes.


PMID: 23533064

DOI: 10.7150/ijms.5845

Other references

Grützner, L.; Pichl, H.; Lehmann, I.; Lenz, H., 1971: Poliomyelitis immunity in the federal republic of Germany in 1969. II. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 217(3): 284-299

Witztum, J.L., 1994: The oxidation hypothesis of atherosclerosis. Lancet 344(8925): 793-795

Morita, J.; Oka, N.; Kadota, K.; Goto, T.; Fujii, S.; Yamamoto, H.; Katoh, H.; Fuku, Y.; Hirono, A.; Maruo, T.; Tanaka, H.; Habara, S.; Ichinohe, T.; Notohara, K.; Mitsudo, K., 2013: Giant-cell myocarditis complicated by heparin-induced thrombocytopenia. Giant-cell myocarditis is a fatal autoimmune disorder that is often associated with other autoimmune diseases. We herein describe a case of giant-cell myocarditis complicated by heparin-induced thrombocytopenia (HIT). A 71-year-old woman was admit...

Scharf, S.C.; Lee, H.B.; Wexler, J.P.; Blaufox, M.D., 1984: Cardiovascular consequences of primary antihypertensive therapy with prazosin hydrochloride. Ten patients with essential hypertension who had no end-organ damage were treated with prazosin, starting with a dose of 1 mg/day. The dose was titrated to a maximal tolerated dose not exceeding 20 mg/day in divided doses or until diastolic blood...

Esser, Gerd, 1989: Studies on the nutrient balance of intensive cultures within the interdisciplinary experiment Lotrex 10E, Hibe 88. Kuttler, W [Editor] [Proceedings of the Society for Ecology] Verhandlungen Gesellschaft fuer Oekologie : 531-536

Peck, G.L.; Blitzer, D.N.; Bulauitan, C.S.; Huntress, L.A.; Truche, P.; Feliciano, D.V.; Dente, C.J., 2016: Outcomes after Distal Pancreatectomy for Trauma in the Modern Era. Multiple stump closure techniques after distal pancreatectomy (DP) for trauma have been described, and all are associated with a significant fistula rate. With increasing emphasis on abbreviated laparotomy, stapled pancreatectomy has become more c...

French, A.E.; Benseler, S.M.; Birken, C.S., 2009: Case 2: A teenage boy with epistaxis. Paediatrics & Child Health 14(2): 99-102

deBoisblanc, B.P.; Meszaros, K.; Burns, A.; Bagby, G.J.; Nelson, S.; Summer, W.R., 1992: Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle. We investigated the effect of dichloroacetate (DCA) on tension generation and carbohydrate metabolism of the rat diaphragm in vitro. Isolated diaphragms were placed in individual organ chambers and were hooked to force-displacement transducers. Ne...

Kaleta, A., 1994: Attitudes to life of rural young people in Poland in the period of system transformation. The article draws on the author's 13 years of research by various methods on the attitudes and values of Polish young people in villages and towns. This shows that the aims of the current rural young generation in Poland are closely related t...

Finkelstein, A.; Schaefer, A.; Chikova, Оlga.; Borodianskiy, K., 2017: Study of Al-Si Alloy Oxygen Saturation on Its Microstructure and Mechanical Properties. One of the main goals of modern materials research is obtaining different microstructures and studying their influence on the mechanical properties of metals; aluminum alloys are particularly of interest due to their advanced performance. Traditio...