+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Leishmaniasis and autoimmune diseases in pediatric age

, : Leishmaniasis and autoimmune diseases in pediatric age. Cellular Immunology 292(1-2): 9-13

Leishmaniasis is a group of diseases caused by the protozoa Leishmania, endemic in the Mediterranean countries. Clinical manifestations can be divided into three different forms: cutaneous leishmaniasis, mucosal leishmaniasis and the visceral leishmaniasis, the most severe form which is potentially lethal if untreated. Immunology and pathogenesis are complex: many different aspects of immune response, resistance and susceptibility to Leishmania have been studied but many others remain to be clarified. The gold standard in diagnosis of visceral Leishmaniasis is the presence of amastigotes in bone marrow or tissue sections. Patients can be initially misdiagnosed as having an autoimmune disease because it may mimic diseases like systemic lupus erythematosus, autoimmune hepatitis, dermatomyositis or others disorders. As in pediatric age the risk of life-threatening complications is very high, leishmaniasis, must be kept in mind to the clinician, in order to avoid wrong diagnosis and an inappropriate immunosuppressive therapy.


PMID: 25240149

DOI: 10.1016/j.cellimm.2014.08.004

Other references

Danese, C.; Howard, J.M.; Bower, R., 1962: Lymphangiography by subcutaneous injection of water soluble radiopaque medium: the role of interstitial pressure. Annals of Surgery 155: 614-619

Adar, T.; Shteingart, S.; Ben-Ya'acov, A.; Shitrit, A.Bar-Gill.; Livovsky, D.M.; Shmorak, S.; Mahamid, M.; Melamud, B.; Vernea, F.; Goldin, E., 2016: The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications. Involvement of eotaxin-1 in inflammatory bowel disease has been previously suggested and increased levels of eotaxin-1 have been described in both ulcerative colitis and in Crohn's disease. The association between serum levels of eotaxin-1 an...

Lohse, K.; Clarke, M.; Ritchie, M.G.; Etges, W.J., 2016: Genome-wide tests for introgression between cactophilic Drosophila implicate a role of inversions during speciation. Models of speciation-with-gene-flow have shown that the reduction in recombination between alternative chromosome arrangements can facilitate the fixation of locally adaptive genes in the face of gene flow and contribute to speciation. However, it...

Hilton, N.Zoe.; Harris, G.T., 2004: Predicting wife assault: a critical review and implications for policy and practice. In this review, the authors examine the research evidence for the prediction of wife assault recidivism, lethal wife assault, and wife assault onset. They also review and present original data on the effect of treatment attendance on wife assault...

Schlaug, G.; Siewert, B.; Benfield, A.; Baird, A.; Lovblad,; Edelman, R.R.; Warach, S., 1997: Time course of the apparent diffusion coefficient in human stroke. Stroke 28(1): 252

Wehner, T.; Lapresto, E.; Tkach, J.; Liu, P.; Bingaman, W.; Prayson, R.A.; Ruggieri, P.; Diehl, B., 2007: The value of interictal diffusion-weighted imaging in lateralizing temporal lobe epilepsy. Background: A subgroup of patients with nonlesional temporal lobe epilepsy (TLE) has no evidence of hippocampal sclerosis on standard temporal lobe protocol MRI. Objective: To investigate whether interictal diffusion-weighted imaging adds lateral...

Heywood, A.; Waldron, H.A.; O'Hare, P.; Dieppe, P.A., 1986: Effect of immersion on urinary lead excretion. British Journal of Industrial Medicine 43(10): 713-715

Watanabe, A.; Kawaharada, N.; Kusajima, K.; Komatsu, S.; Takahashi, H., 1996: Contralateral lung injury associated with single-lung ischemia-reperfusion injury. Background: There have been very few studies on the effect of single-lung ischemia-reperfusion on the function of the contralateral lung. This study was designed to clarify the effect. Methods: Fifteen mongrel dogs were divided into two groups. In...

Perier, R., 1962: Auricular myxoma. Vie Medicale 43: 1293-1295

Sondes, S.; Kennedy, J.M.; Kishner, S.; Lopez, F.A.; Anthony, L., 2003: Clinical case of the month. Severe progressive weakness in a 58-year-old man. Myasthenia gravis. Myasthenia gravis historically has been associated with significant morbidity and mortality rates, and most of those afflicted either died of the disease or became greatly disabled. However, modern understanding of the pathogenesis of this disorde...