+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Limited impact of homeostatic plasticity on motor learning in humans

, : Limited impact of homeostatic plasticity on motor learning in humans. Neuropsychologia 46(8): 2122-2128

Neuroplasticity is the adaptive modification of network connectivity in response to environmental demands and has been identified as a major physiological correlate of learning. Since unrestricted neuroplastic modifications of network connectivity will result in a de-stabilization of the system, metaplastic modification rules have been proposed for keeping plastic connectivity changes within a useful dynamic range. In this connection, the modification threshold to achieve synaptic strengthening is thought to correlate negatively with the history of activity of the respective neurons, i.e. high previous activity enhances the threshold for synaptic strengthening and vice versa. However, the relevance of metaplasticity for actual learning processes has not been tested so far. We reduced or enhanced motor cortex excitability before performance of the serial reaction time task (SRTT), a sequential motor learning paradigm, and a reaction time task (RTT) by transcranial direct current stimulation (tDCS). If homeostatic rules apply, excitability-diminishing cathodal tDCS should improve subsequent motor learning, especially if combined with the partial NMDA receptor-agonist d-cycloserine, which selectively enhances efficacy of active receptors, while excitability-enhancing anodal tDCS should reduce it. Only the results for anodal tDCS, when combined with d-cycloserine, were in accordance with the rules of homeostatic plasticity. We conclude that homeostatic plasticity, as tested here, has a limited influence on implicit sequential motor learning.


PMID: 18394661

DOI: 10.1016/j.neuropsychologia.2008.02.023

Other references

Beier, T.V.; Shibalova, T.A.; Kostenko, L.A., 1978: Cytology of coccidia. This book contains 4 chapters, the first of which describes the life-cycles of coccidia, including toxoplasmids. Chapter 2 deals with the ultrastructures of Eimeria, Isospora, Toxoplasma, Besnoitia, Sarcocystis, Frenkelia and Hammondia at all stag...

Anonymous, 1943: Queensland spinach. Atriplex semibaccata as human food forms the subject of correspondence between E. Hirschfield of Bybera and the Minister for Agriculture and Stock, in which a memorandum by C. T. White is quoted.

Ryzhikov, M.R.; Slepkov, V.A.; Kozlova, S.G.; Gabuda, S.P., 2014: Evolution of chemical bonding and electron density rearrangements during D(3h) → D(3d) reaction in monolayered TiS2: a QTAIM and ELF study. Monolayered titanium disulfide TiS2, a prospective nanoelectronic material, was previously shown to be subject to an exothermic solid-state D3h -D3d reaction that proceeds via a newly discovered transition state. Here, we study the reaction in det...

Anonymous, 1996: Health management awards. Nobody does it better. Health Service Journal 106(5530): 11-16

Macfarlane, S., 2014: Antibiotic treatments and microbes in the gut. Antibiotic therapies are important in combating disease-causing microorganisms and maintaining host health. It is widely accepted that exposure of the gut microbiota to antibiotics can lead to decreased susceptibility and the development of multi-...

Mburu, G.; Ram, M.; Siu, G.; Bitira, D.; Skovdal, M.; Holland, P., 2015: Intersectionality of HIV stigma and masculinity in eastern Uganda: implications for involving men in HIV programmes. Stigma is a determinant of social and health inequalities. In addition, some notions of masculinity can disadvantage men in terms of health outcomes. However, few studies have explored the extent to which these two axes of social inequality inters...

Bock, K.; Meldal, M.; Bundle, D.R.; Iversen, T.; Pinto, B.M.; Garegg, P.J.; Kvanström, I.; Norberg, T.; Lindberg, A.A.; Svenson, S.B., 1984: The conformation of Salmonella O-antigenic oligosaccharides of serogroups A, B, and D1 inferred from 1H- and 13C-nuclear magnetic resonance spectroscopy. The conformational model derived by the HSEA calculation method was used to interpret the n.m.r. data for solutions of oligosaccharides corresponding to the Salmonella serogroups A, B, and D1 antigenic determinants. The favored conformer, derived...

McDonald, L.P., 1981: Repeal PSRO!. Patient Care 15(13): 221, 224, 228 Passim-221, 224, 228 Passim

Benítez-Bribiesca, L., 1999: Evidence-based medicine: a new paradigm?. Modern medical practice is an ever-changing process, and the doctor's need for information has been partially met by continuous medical education (CME) activities. It has been shown that CME activities have not prevented clinical knowledge, a...

Saitoh, H.; Aungst, B.J., 1997: Prodrug and analog approaches to improving the intestinal absorption of a cyclic peptide, GPIIb/IIIa receptor antagonist. Purpose. The purpose of this study was to test whether structural modifications improve the intestinal absorption of DMP 728 (cyclo(D-Abu-NMeArg-Gly-Asp-Amb)), a GPIIb/IIIa receptor antagonist. Methods. In vitro permeabilities of prodrugs and anal...