+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Livedoid vasculopathy and recurrent thrombosis in a patient with lupus: seronegative antiphospholipid syndrome?

, : Livedoid vasculopathy and recurrent thrombosis in a patient with lupus: seronegative antiphospholipid syndrome?. Lupus 19(11): 1340-1343

Livedoid vasculopathy is a rare condition which predominantly affects young women. It is characterized by intense painful purpuric maculae in the legs, ankles and feet, due to thrombosis of the small and medium-sized dermal vessels, in the absence of vasculitis. Livedoid vasculopathy has been frequently associated with hypercoagulable states and antiphospholipid syndrome. We describe a 34-year-old White woman suffering from systemic lupus erythematosus, livedo reticularis, haemolytic anaemia, severe thrombocytopenia and recurrent venous thrombosis who was admitted to the hospital for extremely painful purpuric lesions in her lower limbs. The clinical and histological findings were diagnostic of livedoid vasculopathy. Once the initial sub-therapeutic international normalized ratio levels were corrected, livedoid vasculopathy did not recur. Tests for antiphospholipid antibodies were repeatedly negative. This case, the first reported of livedoid vasculopathy in a patient with seronegative antiphospholipid syndrome and systemic lupus erythematosus, draws attention to livedoid vasculopathy, a thrombotic dermopathy that may be under-diagnosed in patients with antiphospholipid syndrome.


PMID: 20659971

DOI: 10.1177/0961203310373783

Other references

Belt, A.R.; Baldassare, J.J.; Molnár, M.; Romero, R.; Hertelendy, F., 1999: The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells. OBJECTIVE: Up-regulation of prostaglandin production by gestational tissues in the setting of intrauterine infection has been implicated as an important contributor to preterm labor and parturition. In this study we investigated the possible role...

Ciesla F.J.; Krot Alexander N.; Lyons J.R., 2006: Water transport in the solar nebula; implications for the mixing of oxygen isotopic reservoirs. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference 37: (unpaginated

Serrano,L., 2008: Effects of leaf structure on reflectance estimates of chlorophyll content. Assessment of chlorophyll content is a valuable tool for agricultural and non-managed ecosystem studies, since it provides information on key vegetation properties that are, in turn, linked to net primary production. The effects of varying leaf st...

Kleinzeller A., 1970: Some kinetic aspects of the electrolyte dependence of sugar transport in renal tubular cells. Armstrong, W Mcd And A S Nunn Jr (Edited By) Intestinal Transport Of Electrolytes, Amino Acids And Sugars X + 352p Illus Charles C Thomas, Publisher: Springfield, Ill , U S A 232-254

Liu, S.Yan.; Glymour, M.Maria.; Zahodne, L.B.; Weiss, C.; Manly, J.J., 2016: Role of Place in Explaining Racial Heterogeneity in Cognitive Outcomes among Older Adults. Racially patterned disadvantage in Southern states, especially during the formative years of primary school, may contribute to enduring disparities in adult cognitive outcomes. Drawing on a lifecourse perspective, we examine whether state of schoo...

Missero, C.; Filvaroff, E.; Dotto, G.P., 1991: Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins. Transforming growth factors .beta. (TGF-.beta.s) are potent inhibitors of epithelial cell growth in culture and might play a similar role in vivo. Several studies have suggested that acquisition of TGF-.beta. resistance is an important step in epi...

Kootstra, P.R.; Straub, M.H.C.; Stil, G.H.; Van Der Velde, E.G.; Hesselink, W.; Land, C.C.J., 1995: Solid-phase extraction of polycyclic aromatic hydrocarbons from soil samples. A new solid-phase extraction (SPE) method was developed for the analysis of 16 polyaromatic hydrocarbons (PAHs) on the US Environmental Protection Agency priority list, in soil samples. Different types of SPE columns were tested and conditioning a...

Hill, W.C.O., 1937: On the breeding and rearing of certain species of primates in captivity. THE birth of a Semnopithecus priam thersites after a gestation period of at least 196 days is recorded and the growth and colour of the coat are described. An account is given of the rearing of Kasi vetulus from infancy, with observations on post-...

Abstracts., 1993: Abstracts of papers from the 5th VAM congress. Forty kids were divided into four groups according to their age; one day, four weeks, eight weeks, and 12 weeks old groups before they and 16 other pregnant goats were vaccinated against contagious ecthyma using a locally prepared live vaccine. Va...

Kuznetsov, VV., 2001: Alaska pollack stocks off the West Kamchatka present conditions and prospects. Rybnoe Khozyaistvo, 1: 21-24