geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides


, : Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides. Cardiovascular Drugs and Therapy 25(1): 59-67

The objective of this study was to evaluate the long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients at goal for low-density lipoprotein cholesterol (LDL-C) but with persistent hypertriglyceridemia. This is a post hoc analysis of a subset of patients (N = 92) with mixed dyslipidemia treated with moderate-dose statin (rosuvastatin 20 mg, simvastatin 40 mg, or atorvastatin 40 mg) for 12 weeks in three controlled trials who had achieved LDL-C <100 mg/dL but whose triglycerides remained >200 mg/dL, and had fenofibric acid 135 mg added to the moderate-dose statin in a 52-week open-label extension study. Lipid and apolipoprotein (Apo) values and the proportion of patients meeting individual and combined treatment targets with combination therapy were determined at scheduled visits during the 52-week study and compared with baseline (start of extension study). Addition of fenofibric acid to moderate-dose statin for 52 weeks resulted in significant (P < 0.001) improvements in non-high-density lipoprotein cholesterol (non-HDL-C; -9.0%), ApoB (-9.8%), HDL-C (14.9%), and triglycerides (-37.6%) compared with baseline. At final visit, greater proportions of patients achieved optimal levels of individual parameters as well as combined targets of LDL-C + non-HDL-C (60.0% vs 52.2%), LDL-C + non-HDL-C + ApoB (53.3% vs 37.8%, P = 0.007), and LDL-C + non-HDL-C + ApoB + HDL-C + triglycerides (25.6% vs 0.0%) than at baseline. The addition of fenofibric acid to moderate-dose statin in patients whose LDL-C was optimal but whose triglycerides remained >200 mg/dL led to additional improvements in non-HDL-C, ApoB, HDL-C, and triglycerides that resulted in greater proportions of patients attaining optimal levels of the individual parameters as well as simultaneously achieving optimal levels of these parameters and LDL-C.

US$19.90

PMID: 21416219

DOI: 10.1007/s10557-011-6280-1


Other references

Vincent, C.; Boiteau, G., 2001: Pneumatic control of agricultural insect pests. Vincent, C [Editor], Panneton, B [Editor], Fleurat-Lessard, F [Editor] Physical control methods in plant protection 270-281

Silva, M.G.; Henriques, G.; Sánchez, C.; Marques, Pícia.X.; Suarez, C.E.; Oliva, A., 2010: First survey for Babesia bovis and Babesia bigemina infection in cattle from Central and Southern regions of Portugal using serological and DNA detection methods. Incidence of bovine babesiosis in Portugal is currently unknown. In this study, a first survey of Babesia bovis and Babesia bigemina infection in cattle was carried out using blood samples from 406 clinically healthy individuals from different dis...

Tauchnitz, C., 1970: Experiences with trimethoprim-sulfamethoxazole in the chemotherapy of bacterial infections. Zeitschrift für die Gesamte Innere Medizin und Ihre Grenzgebiete 25(16): 734-738

Levinson, S.R., 2000: Diagnosis and treatment of recurrent sinusitis. JAMA 284(10): 1240-1241

Sayers, C.M.; Noeth, S., 2010: Sensitivity of velocities to overpressure within heterogeneous tight gas sand reservoirs. Tight gas sands account for approximately 19% of the total U.S. gas production, and may contain more than 35% of the U.S. recoverable gas resources (Oil and Gas Investor, 2005). In order to test technology for the production of gas from tight gas...

Meneses B., 1991: Standardization of neuropharmacological techniques to identify neuroactive substances. Toxicon 29(10): 1170

D.W.ed, M.; Verbaten, M.N., 2001: Affective pictures processing, attention, and pain tolerance. Two experiments were conducted to determine whether attention mediates the effects of affective distractors on cold pressor pain, or whether the cognitive processes of priming and appraisal best account for the effects. In Experiment I, 65 male re...

Nylenna, M., 1996: To make things correctly, and to make the correct things. Tidsskrift for den Norske Laegeforening 116(17): 1989-1989

Caplan, R., 1991: The evolution of individualized CME. Iowa Medicine 81(2): 48-49

Bathon G.H., 1988: Pelvic fracture in multiple trauma classification by mechanism is key to pattern of organ injury resuscitative requirements and outcome. Journal Of Trauma: 1084