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Long-term prognostic value of early poststress (99m)Tc-tetrofosmin lung uptake during exercise (SPECT) myocardial perfusion imaging

, : Long-term prognostic value of early poststress (99m)Tc-tetrofosmin lung uptake during exercise (SPECT) myocardial perfusion imaging. European Journal of Nuclear Medicine and Molecular Imaging 37(4): 789-798

The aim of this study was to determine the long-term prognostic value of early poststress lung/heart ratio (LHR) of (99m)Tc-tetrofosmin radioactivity. We studied 276 patients (aged 62.2 + or - 8.9 years, 168 men) with stress/rest (99m)Tc-tetrofosmin myocardial gated-SPECT and coronary angiography. To evaluate myocardial ischaemia, we calculated the summed stress score, summed rest score and summed difference score indices. For the eLHR calculation, an anterior image was acquired, 4-6 min after radiotracer injection at stress (eLHR was defined as mean counts per pixel in the lung region of interest divided by the mean counts per pixel in the myocardial region of interest). Cardiovascular death and nonfatal myocardial infarction were considered as hard cardiac events, and late revascularization procedures as soft cardiac events. The Cox proportional hazards model in a stepwise method was used to determine the independent predictors for hard and soft cardiac events. During the follow-up period hard cardiac events occurred in 28 patients (10.1%) and soft cardiac events in 32 patients (11.6%). Implying multiple Cox regression analysis, eLHR was found to be a significant independent predictor for both soft and hard cardiac events. The hazard ratio (for a 0.1 unit increase) was 4.41 (95% CI 1.52-12.73, p=0.006) for soft cardiac events and 4.22 (95% CI 2.07-8.62, p<0.001) for hard cardiac events. The other significant prognostic factors were use of beta-blockers, the summed stress score and the use of nitrates for soft events, and exercise duration and the summed stress score for hard cardiac events. Early poststress (99m)Tc-tetrofosmin LHR has an independent and powerful value in predicting hard and soft cardiac events.


PMID: 20016896

DOI: 10.1007/s00259-009-1312-9

Other references

Cheng, D., 1999: Family planning training in Maryland family practice and obstetrics/gynecology residency programs. To examine the extent of family planning and abortion training in Maryland family practice (FP) and obstetrics/gynecology (OB) residency training programs. All final-year residents in every FP and OB residency training program in Maryland were ask...

Shih, W-Jen.; Li, C-Yang.; Kiefer, V., 2002: Significance of the visualization of bone marrow during dipyridamole Tc-99m tetrofosmin myocardial and gated SPECT. Clinical Nuclear Medicine 27(11): 846-848

Tengfei Xu ???, Dongliang Yuan ???, Yongqiang Yu ???…, 2013: An assessment of Indo-Pacific oceanic channel dynamics in the FGOALS-g2 coupled climate system model. Lag correlations of sea surface temperature anomalies (SSTAs), sea surface height anomalies (SSHAs), subsurface temperature anomalies, and surface zonal wind anomalies (SZWAs) produced by the Flexible Global Ocean-Atmosphere-Land System model: Gri...

Haspeslagh, G., 1972: Superfamille des Ceramonematoides (Cobb, 1933) (Nematoda), evolution et systematique. Annales Soc r zool Belg, 1024: 235-251

Halmagyi, L., 1964: Studies on the population changes of Drepanosiphon platanoidis (Schrk) (Aphidoidea: Callaphididae). Opuscula Zoologica (Budapest): 5: 49-56

Halleck, F.; Friedersdorff, F.; Fuller, T.F.; Matz, M.; Huber, L.; Dürr, M.; Schütz, M.; Budde, K., 2013: New perspectives of immunosuppression. Efficient rejection prophylaxis and excellent short-term results in organ transplantation can not obscure the fact that long-term outcomes have not improved substantially over the last decade with rather constant graft attrition rates beyond the f...

Yamada H., 1975: Tryptophanase from proteus rettgeri purification crystallization and cofactor requirements. Amino Acid & Nucleic Acid: 2-112

Titus, J.A.; Sharrow, S.O.; Segal, D.M., 1983: Analysis of fc immuno globulin g receptors on human peripheral blood leukocytes by dual fluorescence flow micro fluorometry 2. quantitation of receptors on cells that express the okm 1 okt 3 okt 4 and okt 8 antigens. Human peripheral blood mononuclear cells were analyzed for the expression of Fc (IgG) receptors (FcR) by a quantitative dual fluorescence flow microfluorometric (FMF) technique. Mononuclear cells from all donors tested were distributed into 3 dist...

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D.C.Rdova.A.; Estrada.R.; Salas.F.; Sanchez.V., 1955: Muscular dystrophy; clinical, electromyographical and pathological aspects. Revista Cubana de Pediatria 27(7): 417-432