+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion

, : Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. Retina 31(5): 821-828

To evaluate long-term effectiveness and safety of intravitreal injection of ranibizumab as a potential treatment for decreased visual acuity secondary to central retinal vein occlusion. In this prospective interventional case series, patients with central retinal vein occlusion were administered intravitreal ranibizumab 0.5 mg at baseline and monthly for 2 additional doses. Thereafter, the patients were given additional ranibizumab if they had macular edema by optical coherence tomography, leakage during fluorescein angiography, or any intraretinal hemorrhage. There were 35 eyes of 35 patients who at baseline had a mean visual acuity of 44.2 Early Treatment Diabetic Retinopathy Study letters and a mean central macular thickness of 638 μm. At 12 months, mean visual acuity of 32 eyes improved by 16.5 letters and macular thickness decreased to 164 μm (P < 0.001 vs. baseline for each). At 24 months, mean visual acuity of 24 eyes improved by 17.8 letters and macular thickness was 263 μm (P < 0.001 vs. baseline for each). Patients received an average of 10.2 injections during the first year and 6.6 injections during the second year. No cases of endophthalmitis, retinal detachment, or neovascularization were observed. Intravitreal ranibizumab caused a significant improvement in visual acuity and central retinal thickness, which persisted for up to 2 years with minimal side effects.


PMID: 21317833

DOI: 10.1097/IAE.0b013e3181feccc0

Other references

Ahmed, F.E., 2004: Testing of genetically modified organisms in foods. This book presents current information on: the risks and benefits of agricultural biotechnology to people and the environment; the regulations and protocols of testing for genetically modified organisms (GMOs) that have been adopted by European an...

Hoogenboom, G.W.ite, J.; Jones, J.; Boote, K., 1995: A new and improved dry bean simulation model: CROPGRO-DRY BEAN. Annual report 38(38): 15-16

Anonymous, 2013: New Cataclysmic Variable 1RXS J0150170+375614 in Andromeda. We report the discovery of a new cataclysmic variable in MASTER databasewhich is identical to the faint ROSAT X-ray source 1RXS J015017.0+375614. Theobject was observed in outbursts to 14.9m on 2012 Nov. 28 and to 14.3m on 2013Jan. 07, but not det...

Toverud O., 1996: The Swedish Authority SKI's view on the utilities process in siting of a high level nuclear waste repository in Sweden. International Geological Congress, Abstracts = Congres Geologique International, Resumes: ol. 3; Pages 452. 1996.

Chuang, H.T.; Williams, R.; Dalby, J.T., 1987: Criminal behaviour among schizophrenics. This study compared the criminal behaviour of schizophrenic patients with a group of hospitalized medical patients who were matched on the basis of age and sex. In addition to the typically employed dependent measure of offense conviction, this st...

Ogunti, E.O.; Elujoba, A.A., 1993: Laxative activity of Cassia alata. The leaves of C. alata, cultivated in Nigeria, were assayed for laxative properties in rats using official senna leaves (C. acutifolia) as the reference standard. The results suggested that C. alata can be developed as laxative drug as substitute...

Griko, N.; Francis, B.; Candas, M.; Bulla, L., 2001: Specific cleavage of the Cry1Ab toxin receptor BT-R1 in the midgut epithelium of Manduca sexta. BT-R1 is a cadherin-related protein (Mr = 210 kDa) associated with the brush border membrane of larval midgut epithelial cells in Manduca sexta. Although the function of the molecule remains elusive, it binds with high affinity (Kd = 1,073 pM) to...

Zhuang, G-lun., 2003: Assisted reproduction strategy on polycystic ovarian syndrome. Zhonghua Fu Chan Ke Za Zhi 38(8): 484-486

Krueger, E., 1921: Das Gerausch der Ageronia-Arten. Entomologische Rundschau, 38: 35-36: 37-38

Goldberg, S.R.; Bursey, C.R.; Holycross, A.T., 2002: Abbreviata terrapenis (Nematoda: Physalopteridae): an accidental parasite of the banded rock rattlesnake (Crotalus lepidus klauberi). The nematode, Abbreviata terrapenis (Physalopteridae) was found in 16 (6%) of 267 banded rock rattlesnakes (Crotalus lepidus klauberi) from Arizona and New Mexico. Abbreviata terrapenis in C. lepidus represents an accidental parasite in that "...