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Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy

, : Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy. American Journal of Physiology. Heart and Circulatory Physiology 301(4): H1687-H1694

Coronary vascular dysfunction has been observed in several models of heart failure (HF). Recent evidence indicates that exercise training is beneficial for patients with HF, but the precise intensity and underlying mechanisms are unknown. Left ventricular (LV) hypertrophy can play a significant role in the development of HF; therefore, the purpose of this study was to assess the effects of low-intensity interval exercise training on coronary vascular function in sedentary (HF) and exercise trained (HF-TR) aortic-banded miniature swine displaying LV hypertrophy. Six months postsurgery, in vivo coronary vascular responses to endothelin-1 (ET-1) and adenosine were measured in the left anterior descending coronary artery. Baseline and maximal coronary vascular conductance were similar between all groups. ET-1-induced reductions in coronary vascular conductance (P < .5) were greater in HF vs. sedentary control and HF-TR groups. Pretreatment with the ET type A (ETA) receptor blocker BQ-123 prevented ET-1 hypersensitivity in HF animals. Whole cell voltage clamp was used to characterize composite K+ currents (IK+) in coronary smooth muscle cells. Raising internal Ca2+ from 2 to 5 nM increased Ca2+-sensitive K+ current in HF-TR and control, but not HF animals. In conclusion, an ETA-receptor-mediated hypersensitivity to ET-1, elevated resting LV wall tension, and decreased coronary smooth muscle cell Ca2+-sensitive IK+ was found in sedentary animals with LV hypertrophy. Low-intensity interval exercise training preserved normal coronary vascular function and smooth muscle cell Ca2+-sensitive IK+, illustrating a potential mechanism underlying coronary vascular dysfunction in a large-animal model of LV hypertrophy. Our results demonstrate the potential clinical impact of exercise on coronary vascular function in HF patients displaying pathological LV hypertrophy.


PMID: 21841018

DOI: 10.1152/ajpheart.00610.2011

Other references

Litschgi, M., 1985: Hydatidiform mole presenting as an extrauterine pregnancy. Geburtshilfe und Frauenheilkunde 45(3): 189-189

Labrecque, J.; Dumas, F.; Lacroix, A.; Bhat, P.V., 1995: A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid. The pleiotropic effects of retinoids are mediated by two families of nuclear receptors: RAR (retinoic acid receptors) and RXR (retinoid X receptors). 9-cis-Retinoic acid is a specific ligand for RXR receptors, whereas either 9-cis- or all-trans-re...

Gaunt, J.K.; Stowe, B.B., 1967: Analysis and distribution of tocopherols and quinones in the pea plant. A procedure is described and evaluated for the analysis of ubiquinone, plastoquinone, tocopherols and vitamin K1 in Pisum sativum L. Vitamin K1 appears to be absent from the roots of this plant. While the pea seed contains only [gamma]-tocopherol,...

Zoli, L.; Cozzi, P.Giorgio., 2009: Electrophilic activation of aldehydes "on water": a facile route to dipyrromethanes. Shaken .. and stirred: Dipyrromethane, an important building block in porphyrin chemistry, can be easily accessed by a reaction performed on water in the absence of Lewis acids. Thus, a variety of substituted dipyrromethanes were prepared in moder...

Melbye Charles E., 1968: The role of the mining geologist in the Union Pacific natural resource program. This paper was given as an address at the 1967 Annual Meeting of the California Section of AIPG. The Union Pacific Railroad is expanding and diversifying its efforts in the Natural Resources Division and in the Mining Division in 13 western states...

Grahammer, F.; Fischer, K-Georg., 2016: Pulmonary infiltrate and painful nodular leg lesions in a patient with membranous glomerulonephritis. Nocardia otitidis-cavarium is rarely isolated as an infectious pathogen in the western world. We report on a 71-year-old Caucasian man with membranous glomerulonephritis who presented with several seemingly unrelated clinical symptoms that, after...

Grobben, R.B.; van Waes, J.A.R.; van Klei, W.A.; Nathoe, H.M., 2013: Asymptomatic myocardial infarction after non-cardiac surgery; importance of routine testing of troponin concentration. Perioperative myocardial infarction (PMI) is associated with a high mortality rate. Detection of PMI, however, is difficult due to a lack of typical anginal symptoms associated with the use of strong analgesics. Also, characteristic changes on the...

Wender, M.; Waligora, Z., 1960: Amino acids of the white substance of the brain during its development. Acta Physiologica Polonica 11: 914-915

Inoue, S.; Tanaka, Y.; Kawaguchi, M.; Furuya, H., 2010: The efficacy of landiolol for suppressing the hyperdynamic response following laryngoscopy and tracheal intubation: a systematic review. Landiolol is a recently developed, selective short-acting beta1-antagonist. The aim of the study was to evaluate the efficacy of landiolol for suppressing haemodynamic changes induced by laryngoscopy and tracheal intubation (LTI) in Japanese patie...

Ridpath M.G., 1972: The tasmanian native hen tribonyx mortierii part 2 the individual the group and the population. Australia Commonwealth Scientific & Industrial Research Organization Wildlife Research 17(1): 53-90