geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Low-power microfluidic electro-hydraulic pump (EHP)


, : Low-power microfluidic electro-hydraulic pump (EHP). Lab on A Chip 10(1): 74-79

Low-power electrolysis-based microfluidic pumps utilizing the principle of hydraulics, integrated with microfluidic channels in polydimethylsiloxane (PDMS) substrates, are presented. The electro-hydraulic pumps (EHPs), consisting of electrolytic, hydraulic and fluidic chambers, were investigated using two types of electrodes: stainless steel for larger volumes and annealed gold electrodes for smaller-scale devices. Using a hydraulic fluid chamber and a thin flexible PDMS membrane, this novel prototype successfully separates the reagent fluid from the electrolytic fluid, which is particularly important for biological and chemical applications. The hydraulic advantage of the EHP device arises from the precise control of flow rate by changing the electrolytic pressure generated, independent of the volume of the reagent chamber, mimicking the function of a hydraulic press. Since the reservoirs are pre-filled with reagents and sealed prior to testing, external fluid coupling is minimized. The stainless steel electrode EHPs were manufactured with varying chamber volume ratios (1 : 1 to 1 : 3) as a proof-of-concept, and exhibited flow rates of 1.25 to 30 microl/min with electrolysis-based actuation at 2.5 to 10 V(DC). The miniaturized gold electrode EHPs were manufactured with 3 mm diameters and 1 : 1 chamber volume ratios, and produced flow rates of 1.24 to 7.00 microl/min at 2.5 to 10 V(AC), with a higher maximum sustained pressure of 343 KPa, suggesting greater device robustness using methods compatible with microfabrication. The proposed technology is low-cost, low-power and disposable, with a high level of reproducibility, allowing for ease of fabrication and integration into existing microfluidic lab-on-a-chip and analysis systems.

US$19.90

PMID: 20024053

DOI: 10.1039/b911973f


Other references

Roy, C.; Guth, S.; Tuchmann, C.; Gasser, B.; Saussine, C.; Jacqmin, D., 1998: Case report: Mesenteric lipodystrophy associated with renal cell carcinoma: imaging findings. Clinical Radiology 53(2): 152-154

Raja, M.I.; Chinnathurai, A.K.; Bhavan-Isankaran, N., 1968: Influence of phosphate treatment on the available phosphorus of soil and the yield and uptake of phosphorus by pearl-millet in black soil. In trials with pearl-millet ], the treatments were: (a) no fertilizer, (b) 12.55 t f.y.m./ha, (c) 33.6-67.2 kg P2O5 as superphosphate/ha, (d) as (b) + (c). Yields of crops receiving (a), (b), (c) and (d) were 757, 746, 822-1071 and 977-1296 kg gra...

Alatriste-Mondragón, F.; Samar, P.; Cox, H.H.J.; Ahring, B.K.; Iranpour, R., 2006: Anaerobic codigestion of municipal, farm, and industrial organic wastes: a survey of recent literature. Codigestion of organic wastes is a technology that is increasingly being applied for simultaneous treatment of several solid and liquid organic wastes. The main advantages of this technology are improved methane yield because of the supply of addi...

Musacchio, A.; Carmenate, T.; Delgado, M.; Gonzalez, S., 1997: Recombinant Opc meningococcal protein, folded in vitro, elicits bactericidal antibodies after immunization. The meningococcal Opc protein has been expressed as inclusion bodies in Escherichia coli. After cell disruption and successive washing of the insoluble fraction, insoluble proteins were solubilized in presence of the chaotropic agent guanidium hyd...

Sun, Y.; Jia, L.; Williams, M.T.; Zamzow, M.; Ran, H.; Quinn, B.; Aronow, B.J.; Vorhees, C.V.; Witte, D.P.; Grabowski, G.A., 2008: Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous system regions in mammalian prosaposin d...

Anonymous, 2011: No evidence that wild red deer Cervus elaphus on the Iberian Peninsula are a reservoir ofMycobacterium aviumsubspeciesparatuberculosisinfection. The potential role of red deer (Cervus elaphus) as a reservoir ofMycobacterium aviumsubspeciesparatuberculosis(MAP) infection is largely unknown. A total of 332 wild red deer were investigated using post-mortem examination, bacteriology and serolo...

Adloff M.; Ollier J.C., 1986: Financial implication of a colostomy demanding complex appliance. Digestive Surgery 3(2): 146

Flick, R.P.; Pronovost, P.J., 2013: Breaking down the borders of patient safety. Paediatric Anaesthesia 22(10): 944-946

Cobucci, R.; Maisonnette, M.; Macêdo, E.; Santos Filho, F.C.; Rodovalho, P.; Nóbrega, M.M.; Goncalves, A., 2016: Pap test accuracy and severity of squamous intraepithelial lesion. Cytology smears and guided biopsies are the most widely used diagnostic standards for cervical cancer (CC) screening in the developing countries. To evaluate the performance of conventional cytology in estimating the presence and grade of cervical...

Laishley, E.J.; Krouse, H.R., 1978: Stable isotope fractionation by Clostridium pasteurianum. 2. Regulation of sulfite reductases by sulfur amino acids and their influence on sulfur isotope fractionation during SO32- and SO42- reduction. In addition to an assimilatory sulfite reductase, studies of cultures of Clostridium pasteurianum supplemented with methionine, cysteine, and 35SO42- provides evidence for another reductase which is induced by SO32-. This inducible reductase appea...