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Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy

, : Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy. Adipocyte 2(3): 170-175

Obesity has reached epidemic proportions in most of the western world. With obesity comes a variety of adverse health effects such as insulin resistance, dyslipidemia, hypertension, glucose intolerance, and hepatic steatosis. It has become clear that a state of low grade chronic inflammation, typically associated with obesity, and characterized by macrophage infiltration of adipose tissue (AT) and increased production of pro-inflammatory cytokines, plays a crucial role in the development of insulin resistance. The pathogenic mechanisms resulting in AT macrophage recruitment are under intense investigation and remain incompletely understood. We recently demonstrated that lysosomal permeabilization, and subsequent Cathepsin B (CTSB) activation, occurs at the early stages of high fat diet induced weight gain and is preceded by macrophage infiltration into hypertrophied AT resulting in adipocyte cell death through mitochondrial dysfunction. In this report, we demonstrated that another key Cathepsin, Cathepsin D (CTSD), is also activated at the early stages of weight gain. In addition, activated CTSD induced proapoptotic protein activation. In conclusion, our data identify lysosomal CTSD as a potential key mediator of adipocyte cell death during weight gain and obesity.


PMID: 23991364

DOI: 10.4161/adip.24144

Other references

Costa de Pasquale, R.; Ragusa, S.; Circosta, C.; Forestieri, A.M., 1984: Investigations on Dieffenbachia amoena Gentil. I. Endocrine effects and contraceptive activity. Contraceptive activity and the correlated endocrine alterations of an aqueous extract of the leaves of Dieffenbachia amoena were investigated. In female Wistar rats the extract, given for 4 days during the estrous cycle, induced significant variat...

Griffith, R.; Tengnah, C., 2007: A district nurses' guide to disability discrimination law: part 1. District nurses have a unique role in the continuing care of people with disabilities. Some 20% of people are considered disabled and they now have rights under the Disability Discrimination Act 1995. However, to benefit from these rights people m...

Trilla Gros, I.; Panasiti, M.Serena.; Chakrabarti, B., 2016: The plasticity of the mirror system: how reward learning modulates cortical motor simulation of others. Cortical motor simulation supports the understanding of others' actions and intentions. This mechanism is thought to rely on the mirror neuron system (MNS), a brain network that is active both during action execution and observation. Indirect...

Wheeler, H.H., 1997: Nurse occupational stress research. 2: Definition and conceptualization. This article commences with the view that appropriate and clear definitions and conceptualizations of nurse stress are central to meaningful nurse stress research and management. Stress definitions are examined using psychology and nursing literat...

Talpaz, M.; O'brien, S.; Cortes, J.; Giles, F.; Rittweger, K.; Hooftman, L.; Rakhit, A.; Kantarjian, H., 1999: Phase I study of pegylated-interferon alpha-2a in patients with chronic myelogenous leukemia. Blood 94(10 SUPPL 1 PART 1): 530a, Nov 15

Manner, H.; May, A.; Miehlke, S.; Dertinger, S.; Wigginghaus, B.; Schimming, W.; Krämer, W.; Niemann, G.; Stolte, M.; Ell, C., 2006: Ablation of nonneoplastic Barrett's mucosa using argon plasma coagulation with concomitant esomeprazole therapy (APBANEX): a prospective multicenter evaluation. BACKGROUND: Complete reversal of Barrett's epithelium (BE) achieved by treatment with argon plasma coagulation (APC) is variable. The aim of this prospective study was to evaluate the effectiveness of high-power APC in a multicenter trial.MET...

Rozsa, D.; Trencsenyi, G.; Kertai, P.; Marian, T.; Nagy, G.; Banfalvi, G., 2009: Lymphatic spread of mesenchymal renal tumor to metastatic parathymic lymph nodes in rat. Rat mesenchymal renal tumor cells (NeDe) transplanted under the kidney capsule of F344 rats resulted in metastases in the parathymic lymph nodes. Tumor cells were isolated from these tumor-bearing lymph nodes and 106 cells were implanted under the...

Vendramin, E.; Marchesi, L., 2003: Densita e dispersione territoriale della Civetta Athene noctua in Lessinia (VR). Avocetta 27: 185 (Numero speciale)

Pellegrini A.D., 1981: A sequenced questioning paradigm as a general facilitator of preschoolers associative fluency. To investigate the extent to which free play vs. a sequenced questioning paradigm were general facilitators of preschoolers' associative fluency 36 children (15 girls and 21 boys. Mage (mean age) = 52.52 mo.; SD = 9.197 mo.) were randomly ass...

Osame M.; Igata A.; Matsumoto M.; Usuku K.; Izumo S.; Kosaka K., 1987: Htlv i associated myelopathy a report of 85 cases. Annals of Neurology 22(1): 116