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MDM2 inhibitors for pancreatic cancer therapy

, : MDM2 inhibitors for pancreatic cancer therapy. Mini Reviews in Medicinal Chemistry 10(6): 518-526

MDM2 protein negatively regulates p53 and is found to be elevated in cancer cells. An attractive approach towards targeting MDM2 is the use of small molecule inhibitors that bind to MDM2 and disrupt the MDM2-p53 interaction. Our laboratory has been at the forefront in testing MDM2 inhibitors in pancreatic adenocarcinoma (PaCa), a deadly disease with approximately 50% wild-type p53 population. Emerging evidence suggests that apart from regulating p53, MDM2 can influence other key molecules involved in cancer. This review summarizes recent advancements in the development of MDM2 inhibitors, their novel primary and secondary targets and highlights their potential as therapeutics for PaCa.


PMID: 20377522

Other references

Traxer, O.; Smith, T.G.IIi; Pearle, M.S.; Corwin, T.S.ark; Saboorian, H.; Cadeddu, J.A., 2001: Renal parenchymal injury after standard and mini percutaneous nephrostolithotomy. Purpose: Mini percutaneous nephrostolithotomy was developed for use in children and in adults with a reduced renal reserve to minimize the morbidity and renal parenchymal damage presumed to occur with traditional percutaneous nephrostolithotomy. W...

Wang, H.; Fu, X.; Zhang, X., 2001: Isomerization of a uniquely designed amplicon during herpes simplex virus-mediated replication. Herpes simplex virus (HSV) type 1 DNA isomerization was studied using a uniquely designed amplicon that mimics the viral genomic structure. The results revealed that amplicon concatemers frequently contain adjacent amplicon units with their segmen...

Althabe, F.; Sosa, C.; Belizán, Jé.M.; Gibbons, L.; Jacquerioz, F.; Bergel, E., 2006: Cesarean section rates and maternal and neonatal mortality in low-, medium-, and high-income countries: an ecological study. Cesarean section rates show a wide variation among countries in the world, ranging from 0.4 to 40 percent, and a continuous rise in the trend has been observed in the past 30 years. Our aim was to explore the association of cesarean section rates...

Ellis, F.H.; Maggs, P.R., 1981: Surgery for carcinoma of the lower esophagus and cardia. World Journal of Surgery 5(4): 527-533

Weberschock, T.; Strametz, R.; Lorenz, M.; Röllig, C.; Bunch, C.; Bauer, A.; Schmitt, J., 2012: Interventions for mycosis fungoides. Mycosis fungoides is the most common type of cutaneous T-cell lymphoma, a malignant, chronic disease initially affecting the skin. Several therapies are available, which may induce clinical remission for a time. To assess the effects of interventi...

Greenfield, R.; Donkin, S.S.; Cecava, M.J., 1998: Pyruvate carboxylase and phosphoenolpyruvate carboxykinase expression in the transition dairy cow. Journal of Dairy Science 81(SUPPL 1): 320

Höfer, W.; Ache, D.; Höneann, W., 1967: Peutz-Jeghers syndrome with lichenoid tuberculid. Dermatologische Wochenschrift 153(49): 1343-1350

Tyus, F.J.; Austhof, S.I.; Chima, C.S.; Keating, C., 1992: Diet tolerance and stool frequency in patients with ileoanal reservoirs. A questionnaire, mail survey of 105 patients with ileoanal reservoirs (59% male, 41% female; 15-59 years old) was carried out to: estimate stool frequency and timing; evaluate the relation between meal size and frequency, and stool frequency; iden...

Kong, M.; Li, X.; Wang, C.; Ding, C.; Dong, A.; Duan, Q.; Shen, Z., 2012: Tissue distribution and cancer growth inhibition of magnetic lipoplex-delivered type 1 insulin-like growth factor receptor shRNA in nude mice. The targeted delivery of therapeutic genes into specific tissues, as well as the determination of the biological fate and potential toxicity of nanoparticles, remains a highly relevant challenge for gene-based therapies. Type 1 insulin-like growth...

Temperton, H.; Dudley, F.J., 1945: The use of fortified dried food waste for laying pullets reared on diets containing this food. When dried food waste formed about 60% of the rearing ration and 50% of the laying ration, results during the rearing and laying periods were unsatisfactory. Feeding the dried food waste at a 30% level in both periods provided satisfactory growth,...