+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review

, : Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review. Journal of Stroke and Cerebrovascular Diseases 20(1): 47-54

Matrix metalloproteinase-9 (MMP-9) is a possible marker for acute ischemic stroke (AIS). In animal models of cerebral ischemia, MMP expression was significantly increased and was related to blood-brain barrier disruption, vasogenic edema formation, and hemorrhagic transformation. The definition of the exact role of MMPs after ischemic stroke will have important diagnostic implications for stroke and for the development of therapeutic strategies aimed at modulating MMPs. The objectives of the present study were to determine (1) whether MMP-9 is a possible marker for AIS; (2) whether MMP-9 levels correlate with infarct volume, stroke severity, or functional outcome; and (3) whether MMP-9 levels correlate with the development of hemorrhagic transformation after tissue plasminogen activator (t-PA) administration. The literature was searched using MEDLINE and EMBASE with no year restriction. All relevant reports were included. A total of 22 studies (3,289 patients) satisfied the inclusion criteria. Our review revealed that higher MMP-9 values were significantly correlated with larger infarct volume, severity of stroke, and worse functional outcome. There were significant differences in MMP-9 levels between patients with AIS and healthy control subjects. Moreover, MMP-9 was a predictor of the development of intracerebral hemorrhage in patients treated with thrombolytic therapy. MMP-9 level was significantly increased after stroke onset, with the level correlating with infarct volume, stroke severity, and functional outcome. MMP-9 is a possible marker for ongoing brain ischemia, as well as a predictor of hemorrhage in patients treated with t-PA.


PMID: 21044610

DOI: 10.1016/j.jstrokecerebrovasdis.2009.10.008

Other references

Greenstein, J.I.; Gastineau, E.A.; Maurer, A.H., 1995: Functional neuroimaging of gait in multiple sclerosis. Journal of Neuroimmunology 0(SUPPL 1): 62

Lemberg, R., 1954: Chemical structure and biological function of the pyrrole pigments and enzymes. Jour And Proc Roy Soc N S Wales 138(4): 115-135

Celik, B.; Paker, N.; Goksen, G.; Erhan, B.; Gunduz, B., 2016: Poster 357 The Correlation of Nutritional Status with Functional Outcome and Falls in Parkinson's Disease. Pm & R 8(9s): S277-S277

Matheson, K.M.; Barrett, T.; Landine, J.; McLuckie, A.; Soh, N.Li-Weh.; Walter, G., 2016: Experiences of Psychological Distress and Sources of Stress and Support During Medical Training: a Survey of Medical Students. The authors examine the prevalence of psychological distress, the stressors experienced, and the supports used by medical students and residents during their medical training at a Canadian university. This study used an online survey that included...

Kibbe, D.C., 1994: Designing quality into health care information systems. Joint Commission Journal on Quality Improvement 20(11): 591-594

Jones, J.B.yan; Neimann, C., 1962: The a-chymothrypsin catalyzed hydrolysis of several esters of acetyl-1-norvaline. The kinetics of the [alpha]-chymotrypsin catalyzed hydrolysis of the methyl, [beta]-chloroethyl and isopropyl esters of acetyl-L-norvaline ([alpha]-acetamido-n-valeric acid) have been deter-mined in aqueous solutions at 25.0[degree], pH 7.90 and 0...

Yamamura, D.; Gucalp, R.; Carlisle, P.; Cimino, M.; Roberts, J.; Rotstein, C., 1997: Open randomized study of cefepime versus piperacillin-gentamicin for treatment of febrile neutropenic cancer patients. An open-label randomized trial comparing the efficacy and safety of cefepime versus piperacillin plus gentamicin (P+G) given intravenously for the treatment of febrile episodes in neutropenic patients with underlying malignancy was conducted at tw...

Neves, Richard J., 1994: Prognosis for the future Crisis management of an imperiled mussel fauna. Journal of Shellfish Research 13(1): 345

Lefferts, H.L., 1996: Continuity, change and 'development': the case of Thai textiles. The paper focuses on the changes in weaving found in many village households in Thailand and the complex meanings of these changes. The paper examines how these changes might be best conceptualized, as continuity, 'simple' change, or as...

Benavides J.; Toulmond S.; Cornu P.; Scatton B., 1991: Omega 3 peripheral type benzodiazepine binding sites as in vitro and in vivo markers of brain lesions. Racagni, G , N Brunello And T Fukuda (Ed ) International Congress Series, No 968 Biological Psychiatry, Vols 1 And 2; Proceedings Of The 5th World Congress Of Biological Psychiatry, Florence, Italy, June 9-14, Xxviii+886p (Vol 1); Xxxi+949p (Vol 2) Elsevier Science Publishers B V : Amsterdam, Netherlands; (Dist in The Usa And Canada By Elsevier Science Publishing Co , Inc : New York, New York, Usa) Illus 747-749