+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mature survival data for 176 patients younger than 60 years with primary myelofibrosis diagnosed between 1976 and 2005: evidence for survival gains in recent years

, : Mature survival data for 176 patients younger than 60 years with primary myelofibrosis diagnosed between 1976 and 2005: evidence for survival gains in recent years. Mayo Clinic Proceedings 84(12): 1114-1119

In the past 20 years, management of primary myelofibrosis (PMF) has incorporated new treatment approaches, but survival benefits have not been confirmed in controlled studies. This retrospective study includes 176 consecutive patients younger than age 60 years in whom PMF was diagnosed during a 30-year period (1976-2005). Median age at diagnosis was 50 years (range, 18-59 years), and 98 patients (55%) were men. At the time of this report, 99 patients (56%) had died; the 77 surviving patients were followed up for a median of 8 years (range, 4-24 years). Overall median survival was 9.2 years, and 15- and 20-year survival rates were 32% and 20%, respectively. According to the Dupriez Prognostic Scoring System (PSS), median survivals were 12.7, 4.8, and 2.4 years in low- (n=117), intermediate- (n=44) and high- (n=15) risk patients (P<.001). According to the International PSS, median survivals were 13.4, 9.7, 3.3, and 2.4 years in low- (n=76), intermediate-1 (n=50), intermediate-2 (n=29), and high-risk patients (n=8; P<.001). To examine the effect of decade of diagnosis on survival, we divided study patients into 3 groups by year of diagnosis: 1976-1985 (n=36), 1986-1995 (n=45), and 1996-2005 (n=95). The corresponding median survivals were 4.8, 7.3, and "not reached" (P=.003), and the difference in survival was significant during multivariable analysis that included risk scores according to the aforementioned PSSs and age as covariates. The improvement in survival in recent years was most apparent in patients with high/intermediate-risk disease (P<.002), not in those with low-risk disease (P=.42). These observations are encouraging and suggest a salutary effect from modern therapeutic approaches in PMF.


PMID: 19955247

DOI: 10.4065/mcp.2009.0543

Other references

Calkins, G.N., 1900: Nuclear division in Protozoa. Biol Wood's Holl for 1899: 209-230

Honda, Rikita, 1929: The Golgi apparatus in the glandular cells of the submaxillary gland of the adult albino rat. Cytoplasmic inclusions in glandular cells of the submaxillary gland of the albino rat, obtained by the silver and by the osmic methods for the Golgi apparatus, are not the same in the several types of cells. Golgi bodies are increased in number an...

Parker, J.E., 2015: Co-opting the cell-cycle machinery for plant immunity. Plant effector-triggered immunity is a robust cellular defense response activated by a family of intracellular receptors. In this issue of Cell Host & Microbe, Wang et al. (2014) show that receptor-activated defense pathways utilize several c...

Miller, G.D.; Keen, C.L.; Stern, J.S.; Uriu Hare, J.Y., 1997: Copper deficiency and arachidonic acid enhances insulin secretion in isolated pancreatic islets. FASEB Journal 11(3): A404

Zhang, M.; Zhou, M.; Van Etten, R.L.; Stauffacher, C.V., 1997: Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate. The early transition metal oxoanions vanadate, molybdate, and tungstate are widely used inhibitors for phosphatase enzymes. These oxoanions could inhibit such enzymes by simply mimicking the tetrahedral geometry of phosphate ion. However, in some...

Rajeswari, K.S.; Natarajan, S., 2002: Genetics and inheritance of yield and its components in bitter gourd (Momordica charantia L.). The nature of gene action for yield and component characters in bitter gourd was studied in a six parent full diallel cross. The presence of additive and dominant genetic system for fruit length, fruit girth and fruit weight, and dominant gene act...

Bjerring H.C., 1991: Two intracranial ligaments supporting the brain of the brachiopterygian fish polypterus senegalus. Two hitherto unknown ligaments that assist in holding the brain in position occur in the branchiopterygian fish polypterus senegalus. These rounded fibrous cords, placed one behind the other, are called ligamentum intracraniale transversum and lig...

Steiner, W.W.M., 1977: Niche width and genetic variation in hawaiian drosophila. With the use of regression techniques, associations are found between genetic variability and the number of oviposition sites [on plants] utilized by 2 exotic and 16 endemic species of Hawaiian Drosophila. [The 18 spp. studied are D. silvestris, D...

Frei, J.; Ryser, H., 1957: Micro-analytic methods applied to the biochemical study of human hepatic tissue. Helvetica Physiologica et Pharmacologica Acta 15(4): C 62-C 64

Kadotani, T.; Sato, H.; Oama, K.; Takahara, H., 1971: A technical note on the antenatal chromosome analysis by transabdominal fetal skin biopsy. Jinrui Idengaku Zasshi. Japanese Journal of Human Genetics 16(1): 42-47