geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mechanisms of bone repair and regeneration


, : Mechanisms of bone repair and regeneration. Trends in Molecular Medicine 15(9): 417-429

Bone problems can have a highly deleterious impact on life and society, therefore understanding the mechanisms of bone repair is important. In vivo studies show that bone repair processes in adults resemble normal development of the skeleton during embryogenesis, which can thus be used as a model. In addition, recent studies of skeletal stem cell biology have underlined several crucial molecular and cellular processes in bone formation. Hedgehog, parathyroid hormone-related protein, Wnt, bone morphogenetic proteins and mitogen-activated protein kinases are the main molecular players, and osteoclasts and mesenchymal stem cells are the main cells involved in these processes. However, questions remain regarding the precise mechanisms of bone formation, how the different molecular processes interact, and the real identity of regenerative cells. Here, we review recent studies of bone regeneration and repair. A better understanding of the underlying mechanisms is expected to facilitate the development of new strategies for improving bone repair.

US$19.90

PMID: 19740701

DOI: 10.1016/j.molmed.2009.07.002


Other references

Campbell, J.; Sharma, A., 2016: Visual Cross-Modal Re-Organization in Children with Cochlear Implants. Visual cross-modal re-organization is a neurophysiological process that occurs in deafness. The intact sensory modality of vision recruits cortical areas from the deprived sensory modality of audition. Such compensatory plasticity is documented in...

Nimsgern, R.; Courbot, R.; Fadel, N., 1968: 2180 TH propanidide (Epontol). Controlled anesthesia in obstetrics. Bulletin de la Federation des Societes de Gynecologie et Dobstetrique de Langue Francaise 20(1): 70-71

Anonymous, 1945: A study of methods for determination of riboflavin. Biological (1), microbiological (2), and fmorophotometric (3) methods used in determining riboflavin were compared in a study of the riboflavin content of beans, milk, kale, and fish. Low values were noted in baked beans assayed by method (2). Cer...

Shah, R.D.; Wunderink, R.G., 2017: Viral Pneumonia and Acute Respiratory Distress Syndrome. Respiratory viruses are a common cause of severe pneumonia and acute respiratory distress syndrome (ARDS) in adults. The advent of new diagnostic technologies, particularly multiplex reverse transcription polymerase chain reaction, have increased...

Lumachi, F.; Ermani, M.; Marino, F.; Iacobone, M.; Baldessin, M.; Cappuzzo, G.; Zanella, S.; Favia, G., 2006: PCNA-LII, Ki-67 immunostaining, p53 activity and histopathological variables in predicting the clinical outcome in patients with parathyroid carcinoma. Parathyroid carcinoma is uncommon and no reliable histological markers are available for predicting the clinical outcome of patients. The aim of this study was to assess the correlation between survival, histopatological markers, proliferating cel...

Amato, J.J.; Marbey, M.L.; Bush, C.; Galdieri, R.J.; Cotroneo, J.V.; Bushong, J., 1988: Systemic-pulmonary polytetrafluoroethylene shunts in palliative operations for congenital heart disease. Revival of the central shunt. The concept of central shunting in smaller children with the Waterston shunt was initially well accepted. It has been abandoned because of the difficult estimation of lumen size, preferential flow to the right side, and difficulty in the take-down...

Gong, X.; Mao, X.; Chen, Y.; Huang, L.; Liu, W.; Huang, X.; Tan, Z.; Wang, X.; Wu, W.; Chen, Q.; Li, R., 2016: The changes of HRV in refractory epilepsy: The potential index to predict the onset of epilepsy in children. In this study, we examine the potential of heart rate variability (HRV) as an efficient tool for predicting the onset of epilepsy in children. We totally collected 53 seizures EEG and ECG data using Video - EEG - ECG monitoring system. We then sep...

Juang, J-Ming.Jimmy.; Tsai, C-Ti.; Lin, L-Yu.; Liu, Y-Bin.; Yu, C-Chieh.; Hwang, J-Jen.; Chen, J-Jiun.; Chiu, F-Chun.; Chen, W-Jone.; Tseng, C-Den.; Chiang, F-Tien.; Yeh, H-Ming.; Sherri Yeh, S-Fan.; Lai, L-Ping.; Lin, J-Lee., 2016: Unique clinical characteristics and SCN5A mutations in patients with Brugada syndrome in Taiwan. Brugada syndrome (BrS) is a hereditable sudden cardiac death (SCD). Mutations in the <italic>SCN5A</italic> gene (the most common BrS-causing gene) are responsible for 20 25% of this disease in Caucasian populations. However, the preva...

Gajdosik, M.; Tielesch, M., 1972: Clean wool yield from different body regions in Tsigai sheep. Data were obtained on 35 Tsigai X Hampshire Down ewes from a flock maintained at an altitude of 410 m. Body weight averaged 55.5 kg, fleece weight 3.1 kg and lambing rate 117.4%. For samples obtained from shoulder, flank, thigh, neck, back and bel...

Chu, K.C.; Sohal, R.S.; Sun, S.C.; Burch, G.E.; Colcolough, H.L., 1969: Lipid cardiomyopathy of the hypertrophied heart of goldthioglucose obese mice. Journal of Pathology 97(1): 99-103