+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mechanisms of sepsis-induced organ dysfunction

, : Mechanisms of sepsis-induced organ dysfunction. Critical Care Medicine 35(10): 2408-2416

The past several years have seen remarkable advances in understanding the basic cellular and physiologic mechanisms underlying organ dysfunction and recovery relating to sepsis. Although several new therapeutic approaches have improved outcome in septic patients, the far-reaching potential of these new insights into sepsis-associated mechanisms is only beginning to be realized. The Brussels Round Table Conference in 2006 convened >30 experts in the field of inflammation and sepsis to review recent advances involving sepsis and to discuss directions that the field is likely to take in the near future. Current understanding of the pathophysiology underlying sepsis-induced multiple organ dysfunction highlights the multiple cell populations and cell-signaling pathways involved in this complex condition. There is an increasing appreciation of interactions existing between different cells and organs affected by the septic process. The intricate cross-talk provided by temporal changes in mediators, hormones, metabolites, neural signaling, alterations in oxygen delivery and utilization, and by modifications in cell phenotypes underlines the adaptive and even coordinated processes beyond the dysregulated chaos in which sepsis was once perceived. Many pathologic processes previously considered to be detrimental are now viewed as potentially protective. Applying systems approaches to these complex processes will permit better appreciation of the effectiveness or harm of treatments, both present and future, and also will allow development not only of better directed, but also of more appropriately timed, strategies to improve outcomes from this still highly lethal condition.


PMID: 17948334

Other references

Raila, A., 1990: Processing and storage of grain in concrete tower silos. Work to measure the m.c. of grain before processing and select post-harvest processing and storage methods is briefly outlined. Storage in 20 m high concrete tower silos of 9.15 m diam. was studied with reference to cooling, grain temp. and unload...

Ray, P.K.; Seshadri, M.; Poduval, T.B., 1985: Immunity and its role in conventional cancer therapy. Advances in Immunity and Cancer Therapy 1: 29-95

Lagoutine, F.; Legrand, J.; Perrot, C.; Brethon, J.P.; Morel, J., 1972: Half-lives of a few radionucleides. International Journal of Applied Radiation and Isotopes 23(5): 219-224

Tremblay, V.; Beauchamp, L.E., 1965: Doctor Louis-Elie Beauchamp. Laval Medical 36(8): 782-786

Rinaldi-Carmona, M.; Barth, F.; Congy, C.; Martinez, S.; Oustric, D.; Pério, A.; Poncelet, M.; Maruani, J.; Arnone, Mèle.; Finance, O.; Soubrié, P.; L.F.r, Gérard., 2004: SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization. Based on binding, functional, and pharmacological data, this study introduces SR147778 [5-(4-bromophenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide] as a highly potent, selective, and orally active antagonist for...

Reddy, C.B.Rajashekar.; Reddy, S.Rajasekhara.; Naidu, S., 2015: Chemoselective Oxidation of Benzyl, Amino, and Propargyl Alcohols to Aldehydes and Ketones under Mild Reaction Conditions. Catalytic oxidation reactions often suffer from drawbacks such as low yields and poor selectivity. Particularly, selective oxidation of alcohols becomes more difficult when a compound contains more than one oxidizable functional group. In order to...

Tyner, J.; Brown, G., 2004: Improvements to estimating unsaturated soil properties from horizontal infiltration. Current methods to determine unsaturated soil properties are expensive, difficult, and time-consuming. A procedure is presented that quickly estimates the unsaturated hydraulic conductivity, diffusivity, water retention, and sorptivity functions f...

Stoerig, P.; Kleinschmidt, A.; Frahm, J., 1998: No visual responses in denervated V1: high-resolution functional magnetic resonance imaging of a blindsight patient. Following severe cranio-cerebral trauma that affected the optic radiation, patient FS suffers from an incomplete macula-splitting hemianopia. Within the hemianopic field, FS exhibits blindsight, i.e. he detects and discriminates visual stimuli he...

Cederholm, C.J.; Kunze, M.D.; Murota, T.; Sibatani, A., 1999: Pacific salmon carcasses: essential contributions of nutrients and energy for aquatic and terrestrial ecosystems. Pacific salmon and other anadromous salmonids represent a major vector for transporting marine nutrients across ecosystem boundaries (from marine to freshwater and terrestrial ecosystems). Salmon carcasses provide nutrients and energy to biota wit...

Lieberman, Philip, 1992: On Neanderthal speech and Neanderthal extinction. Current Anthropology 33(4): 409-410