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Membranotropic and pro-oxidative effects of alpha-tocopherol short-chain derivatives


, : Membranotropic and pro-oxidative effects of alpha-tocopherol short-chain derivatives. Ukrains'kyi Biokhimichnyi Zhurnal 79(4): 39-45

The development of hemolysis and methemoglobin formation under influence of vitamin E derivatives was investigated on the in vitro model of rat red blood cells. It is established, that the shortening of lateral chains of alpha-tocopherol (T), alpha-tocopheryl acetate (TAc) and alpha-tocopheryl quinone (TQ) to 6 atoms of carbon (accordingly C6-T, C6-TAc, C6-TQ) results in occurrence of hemolysis and prooxidative properties, which are not characteristic of derivatives with native length of isoprenoid side chains. Modifications of chroman ring of short-chain derivatives, in turn, bring the contribution to mechanisms of their action. So, the effect of C6-TAc is caused, basically, physical destabilization of a plasmatic membrane, in C6-TQ effect prevails prooxidative mechanism, while C6-T equally shows membrane-destabilizing and prooxidative properties. Thus the derivatives T with the modified structure chroman nucleus and variability of isoprenoid side chains length show absolutely various properties and in each concrete case should be considered as independent biologically active substances irrespective of T properties.

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PMID: 18219989


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Dhiman, R.; Singh, D.; Gantayala, S.P.; Ganesan, V.L.; Sharma, P.; Saxena, R., 2017: Neuro-Ophthalmology at a Tertiary Eye Care Centre in India. Neuro-ophthalmology as a specialty is underdeveloped in India. The aim of our study was to determine the spectrum and profile of patients presenting to a tertiary eye care center with neuro-ophthalmic disorders. A retrospective hospital-based stud...

Ruiz, M.; Mainetti, H.; Laura Cardarelli, M., 1995: Metabolic control and management of diabetic patients with kidney transplantation. Prensa Medica Argentina 82(2): 151-157

Reynolds, L.P.; Jacobs, G.; Theron, K.I., 2005: The effect of scoring during flower induction or the initiation phase on return bloom in Pyrus communis L. Field experiments were conducted in Western Cape, South Africa, from 2001 to 2003, to determine the influence of scoring during the flower induction phase of pear cv. Doyenne du Comice, Forelle and Rosemarie trees. The yield of Doyenne du Comice i...

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Page, D.L., 1977: Current concepts of "minimal breast cancer". Journal of the Tennessee Medical Association 70(1): 17-18

Egleston, B.L.; Chandler, D.Walt.; Dorgan, J.F., 2010: Validity of estimating non-sex hormone-binding globulin bound testosterone and oestradiol from total hormone measurements in boys and girls. Circulating levels of bioavailable oestradiol and testosterone are often desirable for clinical practice or investigational studies of children. However, assays to measure circulating hormone levels might not always be accessible. We sought to val...

Pisoni D.B., 1975: Processing phonetic features in speech perception. Journal of Psycholinguistic Research 4(3): 283

Lim, S.W.ok; Park, S.K.u; Park, J.; Ahn, H.K.oung; Ju, S.M.oung; Chang, W.I.K.; Chung, J.Y.ung; Koh, Y.W.ok; Park, S.K.ok, 1999: Novel recombinant human thrombopoietin analogues having enhanced in vivo activity. Blood 94(10 SUPPL 1 PART 2): 175b, Nov 15

Xia-Xi-Rong; Shi-Yi; Tong-Mao-Rong; Shao-Hai-Feng, 2003: Clinical analysis of 95 cases with Staphylococcus spp. infection. The predisposing cause of infection by Staphylococcus spp., drug sensitivity and therapeutical experience were analysed retrospectively. The infectious sites were wound, septicemia, lung, abdominal cavity, urinary tract and central nervous system....

Jolly C.J.; Brett F.L.; Cauble R.G., 1974: Genetic and population study of baboons in a hybrid zone in ethiopia. American Journal of Physical Anthropology 41(3): 487