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Meningeal inflammation and demyelination in a patient clinically diagnosed with acute disseminated encephalomyelitis


, : Meningeal inflammation and demyelination in a patient clinically diagnosed with acute disseminated encephalomyelitis. Journal of the Neurological Sciences 346(1-2): 323-327

Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) are both CNS inflammatory demyelinating diseases with overlapping clinical features. A case is reported of a 51-year-old female who presented with headache, progressive aphasia and hemiparesis without preceding infection or vaccination. Brain MRI revealed multiple, often confluent, subcortical white matter lesions without enhancement, affecting predominantly the left cerebral hemisphere. CSF examination failed to reveal oligoclonal bands. Brain biopsy revealed both pathological features of ADEM and findings are consistent with the early stage of MS, including meningeal B and T lymphocytic infiltration, perivenular demyelination, subpial demyelination and discrete confluent plaque-like foci of demyelination. Steroid treatment resulted in remarkable clinical and radiological improvement and there has been no recurrence in six years of follow-up. This case highlights the difficulties in differentiating between ADEM and the first attack of MS and further suggests that ADEM and the early stage of MS, and its tumefactive variant, may have a common underlying pathologic mechanism, which may have a therapeutic implication in treating these diseases.

US$19.90

PMID: 25216555

DOI: 10.1016/j.jns.2014.08.037


Other references

McNab J.M.; Wilson, B.J., 1974: Effects of micronising on the utilisation of field beans (Vicia faba L.) by the young chick. Micronization is a process in which industrial propane is burned over ceramic tile or nichrome wire elements to produce infrared radiation which is absorbed by whole grain or beans to produce rapid internal heating and starch gelatinization. Flake...

Charles, G.; Beaumel, A., 1986: A case of true hermaphroditism. The authors report a case of true hermaphroditism, a rare intersexual condition characterized by the coexistence of ovarian and testicular tissue in the same subject. The authors have analysed this unusual condition in clinical and paraclinical te...

Anonymous, 1896: The Brain Weight Of Mammals. Science 4(101): 833-834

Yoneda, T.; Hiramatsu, M.; Sakamoto, M.; Togasaki, K.; Komatsu, M.; Yamaguchi, K., 1995: Antioxidant effects of "beta catechin". The free radical scavenging effect of "beta catechin", an antioxidant preparation containing green tea extract, ascorbic acid, sunflower seed extract, dunaliella carotene and natural vitamin E, was evaluated. Two techniques were used: el...

Greese, N., 1927: Neue Ichneumoniden aus osteuropaischer Steppen-region. Konowia Vienna, 6: 210-211

Shiotani Y., 1981: Interactions between the pineal gland and the hypothalamo adeno hypophyseal system an ultrastructural study. Jikeikai Medical Journal 28(SUPPL 1): 53-64

Embody, G.C., 1901: Birds of Madison County, New York. Bull Geol and Nat Hist Colgate University, 8vo 1-36

Unruh, T.; Smuda, C.; Busch, S.; Neuhaus, Jürgen.; Petry, W., 2008: Diffusive motions in liquid medium-chain n-alkanes as seen by quasielastic time-of-flight neutron spectroscopy. Different diffusive motions in liquid C(32)H(66) on a picosecond time scale could be disentangled by resolution resolved quasielastic time-of-flight neutron spectroscopy (QENS). It is demonstrated that at all observation times, the dominating moti...

Wu, Y.; Wang, C.; Ren, G.; Liu, X., 2015: Testify patient's blood electrolyte concentration a tendency to approach that of replacement-fluid in continuous renal replacement therapy. To prove with mathematical formula that the patient's blood electrolyte concentration shows a tendency to approach that of replacement-fluid after continuous renal replacement therapy (CRRT). Electrolyte concentration of plasma, replacement-f...

Yeste-Velasco, M.; Mao, X.; Grose, R.; Kudahetti, S.C.; Lin, D.; Marzec, J.; Vasiljević, N.; Chaplin, T.; Xue, L.; Xu, M.; Foster, J.M.; Karnam, S.S.; James, S.Y.; Chioni, A-Myrto.; Gould, D.; Lorincz, A.T.; Oliver, R.Tim.D.; Chelala, C.; Thomas, G.M.; Shipley, J.M.; Mather, S.J.; Berney, D.M.; Young, B.D.; Lu, Y-Jie., 2014: Identification of ZDHHC14 as a novel human tumour suppressor gene. Genomic changes affecting tumour suppressor genes are fundamental to cancer. We applied SNP array analysis to a panel of testicular germ cell tumours to search for novel tumour suppressor genes and identified a frequent small deletion on 6q25.3 af...