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Mesalazine inhibits the beta-catenin signalling pathway acting through the upregulation of mu-protocadherin gene in colo-rectal cancer cells

, : Mesalazine inhibits the beta-catenin signalling pathway acting through the upregulation of mu-protocadherin gene in colo-rectal cancer cells. Alimentary Pharmacology & Therapeutics 31(1): 108-119

Several reports indicate that mesalazine (5-aminosalicylic acid, 5-ASA) is a promising candidate for the chemoprevention of colo-rectal cancer because of its ability to reach the purpose avoiding the unwanted side effects usually associated with prolonged administration of nonsteroidal anti-inflammatory drugs. This activity of 5-ASA is probably the consequence of a number of effects determined on colo-rectal cancer cells, consisting of reduced proliferation, increased apoptosis and activation of cell cycle checkpoints and DNA repair processes. A recent observation has suggested that inhibition of beta-catenin signalling could induce these cellular effects. To characterize better the capacity of 5-ASA to inhibit the beta-catenin signalling pathway. Genes belonging to the beta-catenin signalling pathway were analysed in colo-rectal cancer cell lines treated with 5-ASA using a combination of laboratory assays that are able to detect their phenotypic expression and functional activity. The results obtained indicated that 5-ASA induces the expression of a protein called mu-protocadherin that belongs to the cadherin superfamily and is able to sequester beta-catenin on the plasmatic membrane of treated cells hampering its function. These findings suggest that mu-protocadherin might be employed as a biological marker to monitor the chemopreventive efficacy of 5-ASA.


PMID: 19785626

DOI: 10.1111/j.1365-2036.2009.04149.x

Other references

Timofeev Y.M.; Perevoshchikov A.G.; Knysh V.I., 1988: The use of thermoradiotherapy for anal squamous cell cancer. The results of thermoradiotherapy for anal squamous-cell cancer are reviewed in 23 patients. All patients demonstrated a marked response to treatment. There was no radiation reactions or grave aftereffects. Clinical trials suggest that this organ-...

Carter, J.; Wegmann, T.G., 1973: Mendelian sergregation of a tolerance-inducing self-antigen in the spleen. Cellular Immunology 7(3): 402-409

Schöll, H., 1973: Urine bacteriology. A performance comparison of slide- and agar-plate cultures. Wiener Medizinische Wochenschrift 123(50): 753-754

Aiyar, A.S., 1972: Non-identity of ubiquinol-9 and 'compound x': a precursor of ubiquinone-9 in the rat. Indian Journal of Biochemistry & Biophysics 9(3): 267-268

Weiss, H.; Lesage, E.; Salmeron, B.Jo.; Stein, E.A.; Abulseoud, O.A., 2017: Brief rTMS delivered by H-Coil to a healthy volunteer induced delayed, transient hypomanic symptoms: A case report. Brain Stimulation 10(5): 992-993

Basarova, G., 1990: The structure-function relationship of polymeric sorbents for colloid stabilization of beer. Food structure(3): 175-194

Woolsey, R.D.; Tsang, J.L.K., 1953: Trigeminal neuralgia; surgical decompression of the gasserian ganglion and the posterior root of the trigeminal nerve in treatment. Missouri Medicine 50(2): 99-102

Naumenko, I.M.; Stepanov, A.G.; Kozlova, N.V.; Sabarno, R.V.; Tashlaĭ, L.I., 1970: Working conditions in contact butt welding. Gigiena Truda i Professional'nye Zabolevaniia 14(8): 59-60

Flitters, N.E., 1968: Insect body temperatures determined with microthermoelectric thermometry. The body temperatures of larvae of bollworms, Heliothis zea (Boddie), and adults of house flies, Musca domestica L.; boll weevils, Anthonomus grandis Boheman; American cockroaches, Periplaneta americana (L.); and brown soft scale, Coccus hesperidu...

Janvier, F., 2011: Second combined meeting of the SPE (Exotic Pathology Society) and the Italian Society for Tropical Medicine (SIMET): vector transmitted disease and public health, Venice, 14th and 15th June 2010. Bulletin de la Societe de Pathologie Exotique 103(5): 348-349