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Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk

, : Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk. Genetics and Molecular Research 12(4): 4540-4548

Epoxide hydrolases metabolize exogenous chemicals, including carcinogens such as polycyclic aromatic hydrocarbons. The relationship between microsomal epoxide hydrolase 1 (EPHX1) polymorphisms and esophageal cancer risk has been investigated in various ethnic populations, but the results have been contradictory. We investigated the association of EPHX1 Tyr113His and His139Arg polymorphisms with esophageal cancer via a comprehensive meta-analysis. Publications before August 20, 2012 were included. Eight studies concerning Tyr113His polymorphism associated with 1158 esophageal cancer cases and 1868 controls were identified; 7 studies concerning association of His139Arg with 901 esophageal cancer cases and 1615 controls were also included. A random-effect model was applied, irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate. No significant association was found in either the allele or genotype models for Tyr113His or His139Arg polymorphism with risk for esophageal cancer. Lack of association was also identified in stratified analyses by ethnicity. No publication bias was observed. We conclude that current evidence does not demonstrate association of EPHX1 Tyr113His or His139Arg polymorphisms with risk for development of esophageal cancer.


PMID: 24222229

DOI: 10.4238/2013.October.15.2

Other references

Tomarug, E.; Torescu, I.; Sirbu, V., 1966: An uncommon case concerning sexual relations with exhumed cadavers. Acta Medicinae Legalis et Socialis 19(1): 109-114

Nanni, L.; Vallasciani, S.; Perrelli, L., 2000: H-type rectovaginal fistula associated with the Currarino triad. We describe a case of H-type rectovaginal fistula associated with the Currarino triad (anorectal stenosis, sacral defect, presacral mass). Presenting symptoms included passage of feces per vaginam, signs of intestinal subocclusion without perianal...

Cirino, G.; Cicala, C.; Sorrentino, R.; Sorrentino, L.; Browning, J.L.; Page, C.P., 1994: Human recombinant phospholipase A-2 inhibits platelet aggregation in vitro and in vivo in rat and guinea pig. Platelets contain a phospholipase A2 in their granules which can be released in response to various activating stimuli in vitro as well as in vivo. Human recombinant phospholipase A2 (1-10 micrograms/ml) had no direct effect on platelet aggregatio...

Kufareva, I.; Lenoir, M.; Dancea, F.; Sridhar, P.; Raush, E.; Bissig, C.; Gruenberg, J.; Abagyan, R.; Overduin, M., 2015: Discovery of novel membrane binding structures and functions. The function of a protein is determined by its intrinsic activity in the context of its subcellular distribution. Membranes localize proteins within cellular compartments and govern their specific activities. Discovering such membrane-protein inte...

Alos, L.; Carrillo, R.; Ramos, J.; Baez, J.M.; Mallofre, C.; Fernandez, P.L.; Cardesa, A., 1999: High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases. Three cases of epithelial-myoepithelial carcinoma (EMC) with coexisting areas of high grade carcinoma are reported. In two of the cases there was a previous recurrence, and in all three patients there had been a sudden increase in size before fina...

Lieber, H.Stephen., 2013: Bringing it all together. Interoperability, meaningful use will be the stars at HIMSS13. Modern Healthcare 43(9): 24-24

Burshteĭn, C.I.; Davydova, R.Z., 1977: Anti-organ antibody in antiglobulin absorption test in seroresistant and late forms of syphilis. Vestnik Dermatologii i Venerologii: 28-32

Furiel T., 1979: A disseminated stockwork copper deposit; Erdenet, Mongolia. Mineralia Slovaca: , Pages 467-472. 1979.

Schepker, R.; Fegert, Jörg.M., 2013: The new German reimbursement system for psychiatric hospitals as a "learning system". Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie 41(3): 159-162

Mecocci, P.; Parnetti, L.; Donato, R.; Santucci, C.; Santucci, A.; Cadini, D.; Foa, E.; Cecchetti, R.; Senin, U., 1992: Serum autoantibodies against glial fibrillary acidic protein in brain aging and senile dementias. Autoantibodies against glial fibrillary acidic protein (GFAP) were investigated by ELISA test in sera of patients suffering from senile dementias and in healthy aging people. One hundred eight subjects divided into control, vascular dementia (VD),...