+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Metabolic syndrome, cardiovascular disease and type-2 diabetes

, : Metabolic syndrome, cardiovascular disease and type-2 diabetes. Jpma. Journal of the Pakistan Medical Association 57(10): 511-515

The Metabolic Syndrome, a highly prevalent entity is a clustering of risk factors of metabolic origin that are accompanied by increased risks of cardiovascular disease and type-2 Diabetes Mellitus. These risk factors are atherogenic dyslipidaemia, elevated blood pressure, raised plasma glucose, a prothrombotic and a proinflammatory states. Two major underlying risk factors for the metabolic syndrome are obesity and Insulin resistance; exacerbated by physical inactivity, advancing age, endocrinal and genetic factors. The condition is progressive and in many patients eventually culminates in type-2 Diabetes, which further enhances the risk of cardiovascular disease. Primary treatment for the metabolic syndrome is life style therapy i.e. weight loss, increased physical activity and antiatherogenic diet. As the condition progresses, drug therapies may be required to ameliorate the individual risk factors. Ultimately, it may be possible to develop drugs that will simultaneously modify all the risk factors. However, they are under development and so far have not reached the level of clinical practice.


PMID: 17990428

Other references

H.D.agert; R.D.H.ndman, 1995: Continuous GPS monitoring of elastic strain in the northern Cascadia subduction zone. Geophysical Research Letters 22(7): 755

Kitsugi, E., 1978: Control of dental caries among 6 to 14 year old school children by the application of preventive treatment and incremental care. Koku Eisei Gakkai Zasshi 28(2): 244-265

Kaplan, H.; Bilgin, H.; Yilmaz, S.; Binici, H.; Oztas, A., 2010: Structural damages of LAquila Italy earthquake. On 6 April 2009 an earthquake of magnitude 6.3 occurred in L'Aquila city, Italy. In the city center and surrounding villages many masonry and reinforced concrete (RC) buildings were heavily damaged or collapsed. After the earthquake, the insp...

Pilla, A.M.; Bernardini, G., 1970: Effect of environmental temperature on lactose content of buffaloes' milk. Lactose was estimated in combined p.m. and a.m. milk from each of 8 buffaloes, daily for the 1st wk, weekly for the 1st month and then fortnightly for the rest of the lactation. The buffaloes calved during the 3 months, 11 Nov. 1967 to 8 Feb. 1968...

Devi, B.C.R.; Tang, T.S.; Corbex, M., 2007: Reducing by half the percentage of late-stage presentation for breast and cervix cancer over 4 years: a pilot study of clinical downstaging in Sarawak, Malaysia. The registry of the Oncology Departmental in Sarawak General Hospital showed that 79% of nasopharyngeal, 77% of breast and 70% of cervix cancer patients were diagnosed at an advanced stage (stages III and IV) for year 1993. Hence, a low cost Early...

Goto, Y.; Tamachi, H.; Moriguchi, E.H., 1993: Eicosapentaenoic acid and atherosclerosis. Prostaglandins Leukotrienes & Essential Fatty Acids 48(5): 337-342

Bernauer, U.; Vieth, B.; Ellrich, R.; Heinrich Hirsch, B.; Jaenig, G.R.ediger; Gundert Remy, U., 1999: CYP2E1-dependent benzene toxicity: The role of extrahepatic benzene metabolism. Benzene, a ubiquitous environmental pollutant, is haematotoxic and myelotoxic. As has been shown earlier, cytochrome P450 2E1 (CYP2E1)-dependent metabolism is a prerequisite for the cytotoxic and genotoxic effects of benzene, but which of the benz...

Yu, J.S.; Greenway, G.; Resnick, D., 1994: Myelofibrosis associated with prominent periosteal bone apposition. Report of two cases. Myelofibrosis is a myeloproliferative disorder that is characterized by splenomegaly and bone marrow replacement by fibrous tissue. The predominant radiographic feature is osteosclerosis; however, in rare instances, periosteal bone apposition or p...

Hafner, DJ.; Hafner, JC.; Hafner, MS., 1984: Skin plus skeleton preparation as the standard mammalian museum specimen. Curator, 272: 141-145

Pedro Antonio M.A., 2000: The role of SEAMIC in minerals resources management and industrial minerals development in eastern and Southern Africa. Africa Geoscience Review 7(2): 259-265