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MicroRNA miR-125b causes leukemia


, : MicroRNA miR-125b causes leukemia. Proceedings of the National Academy of Sciences of the United States of America 107(50): 21558-21563

MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of up to 90-fold normal. Moreover, miR-125b is also up-regulated in patients with B-cell acute lymphoblastic leukemia carrying the t(11;14)(q24;q32) translocation. To decipher the presumed oncogenic mechanism of miR-125b, we used transplantation experiments in mice. All mice transplanted with fetal liver cells ectopically expressing miR-125b showed an increase in white blood cell count, in particular in neutrophils and monocytes, associated with a macrocytic anemia. Among these mice, half died of B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, or a myeloproliferative neoplasm, suggesting an important role for miR-125b in early hematopoiesis. Furthermore, coexpression of miR-125b and the BCR-ABL fusion gene in transplanted cells accelerated the development of leukemia in mice, compared with control mice expressing only BCR-ABL, suggesting that miR-125b confers a proliferative advantage to the leukemic cells. Thus, we show that overexpression of miR-125b is sufficient both to shorten the latency of BCR-ABL-induced leukemia and to independently induce leukemia in a mouse model.

US$19.90

PMID: 21118985

DOI: 10.1073/pnas.1016611107


Other references

Pàmies, O.; Magre, M.; Diéguez, M., 2016: Extending the Substrate Scope for the Asymmetric Iridium-Catalyzed Hydrogenation of Minimally Functionalized Olefins by Using Biaryl Phosphite-Based Modular Ligand Libraries. Asymmetric hydrogenation is one of the most efficient and atom-economical tools to prepare chiral molecules. However, the enantiodiscrimination of simple, minimally functionalized olefins is still challenging and requires more sophisticated ligand...

Beeson, R.C.; Yeager, T.H., 1996: Container spacing increases container capture of overhead irrigation as application efficiency declines. Hortscience 31(4): 606

Pexa, M., 1979: Unusual hand injuries. Rozhledy V Chirurgii 58(9): 564-570

Gibson, P.Reed.; Sledd, L.G.; McEnroe, W.H.; Vos, A.P., 2012: Isolation and lack of access in multiple chemical sensitivity: A qualitative study. This paper describes a qualitative interview study of 26 persons with multiple chemical sensitivity (MCS), also referred to as chemical intolerance. We used a phenomenological perspective and planned to focus on the impact of MCS on relationships,...

Ratajczak, T.; Carrello, A.; Minchin, R.F., 1995: Biochemical and calmodulin binding properties of estrogen receptor binding cyclophilin expressed in Escherichia coli. Bovine estrogen receptor binding cyclophilin (ERBC), a cyclophilin component of the unactivated estrogen receptor, has been efficiently expressed in Escherichia coli as a fusion with glutathione S-transferase (GST) and purified by single-step chro...

Man'kovskiĭ, N.B.; Verkhratskiĭ, N.S., 1980: National health program "prolongation of life". Vestnik Akademii Meditsinskikh Nauk SSSR: 85-87

Anscombe, A.R., 1966: Hospital link. Manchester Medical Gazette 45(2): 40-42

Wortman, Morris, 1997: Elective termination of pregnancy. Leppert, P C [Editor], Howard, F M [Editor] Primary care for women : 153-158

Bakin, L.M., 1962: Transplantation of homologous cartilage following enucleation. Vestnik Oftalmologii 75: 47-53

Hughes, S-Jane.; Wall, N.; Scholfield, C.Norman.; McGeown, J.Graham.; Gardiner, T.A.; Stitt, A.W.; Curtis, T.M., 2005: Advanced glycation endproduct modified basement membrane attenuates endothelin-1 induced [Ca2+]i signalling and contraction in retinal microvascular pericytes. To assess the effects of advanced glycation endproduct (AGE) modification of vascular basement membrane (BM) on endothelin-1 (Et-1) induced intracellular [Ca2+] ([Ca2+]i) homeostasis and contraction in retinal microvascular pericytes (RMP). RMPs w...