+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice

, : MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324(5935): 1710-1713

MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression by binding to target messenger RNAs (mRNAs), leading to translational repression or degradation. Here, we show that the miR-17approximately92 cluster is highly expressed in human endothelial cells and that miR-92a, a component of this cluster, controls the growth of new blood vessels (angiogenesis). Forced overexpression of miR-92a in endothelial cells blocked angiogenesis in vitro and in vivo. In mouse models of limb ischemia and myocardial infarction, systemic administration of an antagomir designed to inhibit miR-92a led to enhanced blood vessel growth and functional recovery of damaged tissue. MiR-92a appears to target mRNAs corresponding to several proangiogenic proteins, including the integrin subunit alpha5. Thus, miR-92a may serve as a valuable therapeutic target in the setting of ischemic disease.


PMID: 19460962

DOI: 10.1126/science.1174381

Other references

Healey, J.E.; Gallager, H.S.; Moore, E.B.; Clark, R.L.; Sheena, K.S.; Mcbride, C.M., 1965: Experiences With Plastic Adhesive In The Nonsuture Repair Of Body Tissues. American Journal of Surgery 109: 416-423

Azouz, E.M.; Jurik, A.G.; Bernard, C., 1998: Sternocostoclavicular hyperostosis in children: a report of eight cases. The aim of this paper is to clarify the clinical and radiologic features of sternocostoclavicular hyperostosis by reviewing eight previously unpublished cases in children, identifying its similarities to chronic recurrent multifocal osteomyelitis...

Zhou, J.R.; Zhong, Y.; Yu, L.; Jones, J.; Blackburn, G.L., 2000: Synergy between soy and tea active components target the growth of estrogen-dependent MCF-7 human breast carcinoma in mice. FASEB Journal 14(4): A295, March 15

Swain, Roger B., 1986: A good twenty-five-dollar garden bench. Horticulture 64:

Moody, Pw, 1991: Reply to: Comments on intensity-quantity aspects of soil phosphorus. Australian journal of soil research9(1): 13-14

Khokhlova, I.S.; Ghazaryan, L.; Krasnov, B.R.; Degen, A.Allan., 2009: Does acquired resistance of rodent hosts affect metabolic rate of fleas?. We studied whether (a) previous infestation of a rodent host with fleas and (b) the reproductive effort of fleas affect the rate of CO(2) emission in two flea species, host-specific Parapulex chephrenis and host-opportunistic Xenopsylla ramesis wh...

Armstrong, M.L.; Gessner, B.A., 1990: Texas nurses are reading, yet. The time Texas nurses spend reading professional literature is similar with physicians, yet they also read almost twice as much general material. A significant relationship was demonstrated between nurses who are members of nursing organizations a...

Gough P.M.; Dierks R.E., 1972: Passive hem agglutination test for antibodies against rabies virus. Bulletin of the World Health Organization 45(6): 741-745

Storm, S.; Weiss, M.D., 2003: Self-inflicted tourniquet paralysis mimicking acute demyelinating polyneuropathy. Tourniquet paralysis is an uncommon complication of surgery, and self-inflicted tourniquet paralysis has never been documented to our knowledge. We report a patient with bilateral self-induced tourniquet paralysis of the lower extremities, whose s...

Reilly, E. ., 1984: Highlights of the fall season. Region 8 - Hudson-Mohawk. Kingbird, 341: 62-65