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MicroRNAs as prime players in a combinatorial view of evolution


, : MicroRNAs as prime players in a combinatorial view of evolution. Rna Biology 5(3): 120-122

MicroRNA-mediated gene regulation allows the establishment of complex circuitries acting in many different phases of development and differentiation. MicroRNA genes and their target sites are under Darwinian selection and the idea that microRNAs can act as prime players in determining species identity has been recently speculated. By studying the 3'-untranslated regions (UTRs) of orthologous neuronal genes, we found that, at variance with house-keeping genes, the density of miRNA target sites involved in complex cell networks increased from invertebrates to human, paralleling the increase in species complexity. This suggests that genes contributing to complex cellular functions had a selective advantage for acquiring and potentiate miRNA-mediated regulation.

US$29.90

PMID: 18698151


Other references

Legge, V.; O'Loughlin, K., 2000: The balance of benefit: a review of intergenerational transfers in Australia. This article reviews the financial and nonfinancial transfers taking place intergenerationally and between older people and the community. Secondary data were used in the analysis and discussion to provide an overview of the Australian context. Wi...

Poppe, S.G.bel, M.P.ters, D., 1973: First feeding value parameters of whole-crop cereal pellets. Tierzucht 27 (6) 270-271

Masters, C.J., 1963: Nucleic acids and protein stores in the Merino sheep. Eight Merino ewes aged 3 to 4 years were freely fed on lucerne chaff for 3 weeks, then on 3 kg chaffed wheat straw per week (digestible crude protein 0.5%) for 8 weeks, to simulate diet under drought conditions. Well nourished adults and young of...

Arendt, M.; Munk-Jørgensen, P.; Sher, L.; Jensen, S.Olrik.Wallenstein., 2013: Mortality following treatment for cannabis use disorders: predictors and causes. The aim of the study was to determine excess mortality associated with cannabis use disorders. Individuals entering treatment for cannabis use disorders were followed by use of Danish registers and standardized mortality ratios (SMRs) estimated. P...

Pino A.E., 1986: The role of arthroscopy in diagnosis and treatment of fractures about the knee. Orthopaedic Transactions 10(3): 633

Diedrich, J.F.; Hsiao, K.K., 1994: Neurotoxicity of the prion protein. Neurobiology of Aging 15(SUPPL 1): S157

Freitas, H.; Prasad, M.N.V.; Pratas, J., 2003: Analysis of serpentinophytes from north-east of Portugal for trace metal accumulation--relevance to the management of mine environment. In north-east of Portugal, the serpentinized area is about 8000 ha with a characteristic geology and flora. The serpentine plant community and respective soils were analyzed to examine the trace metal budget in different tissues of the plants exhi...

Burrows, W.; Mckee, T.J.hnson, S., 1979: Risk analysis in agricultural meteorology: an example using supplemental irrigation. Discussants remarks. Proceedings: Weather and agriculture symposium ober 1-2-1979 Kansas City Missouri Research and its applications to crop production in the 1980's sponsored by University of Missouri Columbia Science and Education Administration USDA and State Agricultural Experiment Stations: 207

Dunlap, R.K.; Marver, D.; Morrow, B.J.; Green, B.R.; Elam, J., 2011: A community health service-learning roundtable: nursing education partnership for community health improvement. This article describes the formation of a campus-community partnership that focused its efforts on a single vulnerable community within an urban setting. Challenges that were faced and how those challenges were engaged to maintain a viable serving...

Keller, H.H.; D.P.ada, M., 1985: Evidence for the release of 1-methyl-4-phenylpyridinium (MPP+) from rat striatal neurons in vitro. [3H]MPP+ (1-[methyl-3H]4-phenylpyridinium) is taken up into rat striatal slices in a temperature-, time- and Na+-dependent process blocked by dopamine (DA) uptake inhibitors. Once taken up, authentic [3H]MPP+ is released at 37 degrees C by 15 mM K...