geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Microparticles in tumor progression


, : Microparticles in tumor progression. Thrombosis Research 129 Suppl 1: S132-S136

Microparticles (MP) are shed from the surface of activated or apoptotic blood cells and their levels in plasma reflect a balance between cell stimulation, proliferation, and death. MP production occurs through vesiculation of cell membranes, and involves cytoskeletal changes and a shift in the normal phospholipid asymmetry. The expression on the majority of MP of the anionic phosphatidylserine (PS) is responsible for the capacity of MP to support blood coagulation activation. In some cases, PS expression is also associated, in the same MP, with the presence of active Tissue Factor, the main activator of blood coagulation. Elevation in plasma levels of MP have been described in numerous clinical conditions, most of which also associated with an increased thrombotic risk. Particularly, MP have been found to be increased in both solid and hematological malignancies, including myeloproliferative neoplasms. A role of MP in tumor progression has been suggested by both in vitro and in vivo studies. Evidence exists that MP of platelet origin are the main players in this process, being rich in pro-angiogenic factors. The utility of measuring MP as a diagnostic and prognostic marker is currently a subject of intense investigation. The possibility to inhibit MP production by pharmacological interventions represents a future challenge.

US$19.90

PMID: 22682124

DOI: 10.1016/S0049-3848(12)70033-6


Other references

Balasubramanian, S.; Ganesh, R., 2008: Vitamin D deficiency in exclusively breast-fed infants. Exclusive breast-feeding is recommended up to 6 months of age with all its beneficial effects on child survival. Several studies have concluded that adequate intake of vitamin D cannot be met with human milk as the sole source of vitamin D. As br...

Shankar, A.; Hayward, J.; Kirkwood, A.; McCarthy, K.; Hewitt, M.; Morland, B.; Daw, S., 2014: Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy. The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relap...

Messer, K.D.; Schmit, T.M.; Kaiser, H.M., 2004: Optimal institutional mechanisms for funding generic advertising: an experimental analysis. Given the uncertain legal status of generic advertising programmes for agricultural commodities, alternative voluntary funding institutions that could provide a high level of benefits to producers are investigated. This experimental study simulate...

Hamilton D.J.; George B.; Sommers C.; Zaniewski M.; Bryan N.; Boyd A.E.IIi, 1981: Comparison of pergolide and bromocriptine in prolactin disorders. Clinical Research 29(5): 860A

Mondal, A.; Sinha, A.; Saha, A.; Jana, N.R., 2012: Tunable catalytic performance and selectivity of a nanoparticle-graphene composite through finely controlled nanoparticle loading. Graphene-based composites offer enhanced catalytic performance of metal and semiconductor nanoparticles, but their development is challenging because catalytic performance strongly depends on the structure and composition of the composite. Herein...

Lammers T.G., 1992: New combinations for asian campanulaceae. Three new combinations at subspecific rank are proposed for Asian Campanulaceae: Adenophora morrisonensis subsp. uehatae (Yamamoto) Lammers, comb. et stat. nov. (based upon Adenophora uehatae Yamamoto); Condonopsis javanica subsp. japonica (Maxim....

Silverberg, M.J.; Leyden, W.; Hurley, L.; Go, A.S.; Quesenberry, C.P.; Klein, D.; Horberg, M.A., 2009: Response to newly prescribed lipid-lowering therapy in patients with and without HIV infection. Annals of Internal Medicine 150(5): 301-313

Afanas yev Y.T.; Tomkina A.V., 1981: The petroleum- and gas-bearing capacity of very deep depressions. Pages 3-7 1981

Penman, V.J., 1966: A patient with multiple injuries. Nursing Times 62(11): 358-360

Martin, R.M.; Gunnell, D.; Smith, G.Davey., 2004: Breastfeeding in infancy and blood pressure in later life: systematic review and meta-analysis. The influence of breastfeeding on blood pressure in later life is uncertain. A systematic review of published studies from which estimates of a mean difference (standard error) in blood pressure between breastfed and bottle-fed subjects could be d...