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Mild cognitive impairment and development of dementia

, : Mild cognitive impairment and development of dementia. Psychiatrische Praxis 35(7): 331-336

In order to identify mildly cognitively impaired subjects, MILD COGNITIVE IMPAIRMENT: (MCI) represents a current and well-discussed concept. Prevalence and conversion rates, relative risks and data on the sensitivity and specifity of MCI for the development of dementia will be calculated. 980 subjects aged 75 years and over who participated in the Leipzig Longitudinal Study of the Aged (LEILA 75+) were clinically interviewed and cognitively tested at regularly intervals over a mean period of six years. At baseline, the prevalence of MCI was 19.3 %, including (original) and 41.5 % excluding (modified) the criterion of subjective cognitive complaints. Diagnoses of original and modified amnestic MCI-subtypes were associated with relative risks of more than three for the development of dementia. MCI represents a risk factor for dementia, mainly if the cognitive impairments are related to the area of memory. However, in order to predict dementia reliably, further findings (e. g. biomarkers) are required.


PMID: 18504687

DOI: 10.1055/s-2008-1067395

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