+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Mitochondrial gateways to cancer

, : Mitochondrial gateways to cancer. Molecular Aspects of Medicine 31(1): 1-20

Mitochondria are required for cellular survival, yet can also orchestrate cell death. The peculiar biochemical properties of these organelles, which are intimately linked to their compartmentalized ultrastructure, provide an optimal microenvironment for multiple biosynthetic and bioenergetic pathways. Most intracellular ATP is generated by mitochondrial respiration, which also represents the most relevant source of intracellular reactive oxygen species. Mitochondria participate in a plethora of anabolic pathways, including cholesterol, cardiolipin, heme and nucleotide biosynthesis. Moreover, mitochondria integrate numerous pro-survival and pro-death signals, thereby exerting a decisive control over several biochemical cascades leading to cell death, in particular the intrinsic pathway of apoptosis. Therefore, it is not surprising that cancer cells often manifest the deregulation of one or several mitochondrial functions. The six classical hallmarks of cancer (i.e., limitless replication, self-provision of proliferative stimuli, insensitivity to antiproliferative signals, disabled apoptosis, sustained angiogenesis, invasiveness/metastatic potential), as well as other common features of tumors (i.e., avoidance of the immune response, enhanced anabolic metabolism, disabled autophagy) may directly or indirectly implicate deregulated mitochondria. In this review, we discuss several mechanisms by which mitochondria can contribute to malignant transformation and tumor progression.


PMID: 19698742

DOI: 10.1016/j.mam.2009.08.002

Other references

Büller, H.R.; Bethune, C.; Bhanot, S.; Gailani, D.; Monia, B.P.; Raskob, G.E.; Segers, A.; Verhamme, P.; Weitz, J.I.; Buller, H.; Weitz, J.; Gailani, D.; Segers, A.; Bhanot, S.; Prins, M.; Beenen, L.; Otten, H-Martin.; Roos, Y.; Slagboom, T.; Verhamme, P.; Vandenbriele, C.; Vanassche, T.; Segers, A.; Dani, V.; Bhanot, S.; Bethune, C.; Schulz, D.; Shapiro, C.; Kwoh, K.; Jung, B.; Gawinek-Samelczak, A.; Kaemmer, C.; Angelov, S.; Stavrev, V.; Kinov, P.; Dessouki, E.; Abuzgaya, F.; Baurovskis, A.;, 2015: Factor XI antisense oligonucleotide for prevention of venous thrombosis. Experimental data indicate that reducing factor XI levels attenuates thrombosis without causing bleeding, but the role of factor XI in the prevention of postoperative venous thrombosis in humans is unknown. FXI-ASO (ISIS 416858) is a second-genera...

Garg, S.; Malik, A.; Singh, R., 2013: Healthy corporate house means healthy nation. India is now an economic powerhouse. The country is home to some of the best global companies. These companies provide various services to the society through corporate social responsibility initiatives. These are their obligations toward the soci...

Huster, D.; Müller, P.; Arnold, K.; Herrmann, A., 2003: Dynamics of lipid chain attached fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) in negatively charged membranes determined by NMR spectroscopy. We have determined the average location and dynamic reorientation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to a C12 sn-2 chain of a phosphatidylserine (PS) analogue (C12-NBD-PS) in zwitterionic phosphatidylcholine (PC) a...

Guidotti, A.; Konkel, D.R.; Ebstein, B.; Corda, M.G.; Wise, B.C.; Krutzsch, H.; Meek, J.L.; Costa, E., 1982: Isolation, characterization, and purification to homogeneity of a rat brain protein (GABA-modulin). gamma-Aminobutyric acid (GABA)-modulin is a brain neuropeptide that appears to modulate specific high-affinity (20 nM) GABA recognition sites in brain. When added to crude synaptic membranes this peptide inhibits binding of [3H]GABA to the high-af...

Gradstein Felix M., 1985: Ranking and scaling in exploration micropaleontology. Pages 109-160 1985

Kann An, K.K., 1924: A new Remedy for Sugarcane Borers: preliminary Note. Of the borers attacking sugar-cane in Mysore, three are species of Diatraea, two of Scirpophaga and one of Sesamia. To trap the adult moths heaps of cane trash are placed in the fields, and the moths that hide in them by day are collected. The wor...

Asiamah George K., 1990: Geophysical prospecting in the search for gold within the Ashanti greenstone belt of Ghana. Pages 46-56 1990

Bezy, R.L., 1967: A new night lizard Xantusia vigilis sierrae from the southern Sierra Nevada in California. Journal of the Arizona Academy of Science, 4: 163-167

Samson Dollfus D.; Szeibert J.; Parain D.; Senant J.; Menard J.F., 1982: Electro encephalographic analysis and prognosis in 125 cases of nonhyperpyretic seizures occurring in children under 3 years. Electroencephalography & Clinical Neurophysiology 53(6): 81P

Fan, J.; Wang, J.; Bensadoun, A.; Lauer, S.J.; Dang, Q.; Mahley, R.W.; Taylor, J.M., 1994: Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. To elucidate the precise metabolic roles of hepatic lipase (HL), a human HL cDNA in a liver-specific expression vector was used to generate transgenic lines in the rabbit, an animal that normally expresses low levels of this enzyme. HL was detecte...