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Modeling the dynamical effects of anesthesia on brain circuits

, : Modeling the dynamical effects of anesthesia on brain circuits. Current Opinion in Neurobiology 25: 116-122

General anesthesia is a neurophysiological state that consists of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. General anesthesia has been used in the United States for more than 167 years. Now, using systems neuroscience paradigms how anesthetics act in the brain and central nervous system to create the states of general anesthesia is being understood. Propofol is one of the most widely used and the most widely studied anesthetics. When administered for general anesthesia or sedation, the electroencephalogram (EEG) under propofol shows highly structured, rhythmic activity that is strongly associated with changes in the patient's level of arousal. These highly structured oscillations lend themselves readily to mathematical descriptions using dynamical systems models. We review recent model descriptions of the commonly observed EEG patterns associated with propofol: paradoxical excitation, strong frontal alpha oscillations, anteriorization and burst suppression. Our analysis suggests that propofol's actions at GABAergic networks in the cortex, thalamus and brainstem induce profound brain dynamics that are one of the likely mechanisms through which this anesthetic induces altered arousal states from sedation to unconsciousness. Because these dynamical effects are readily observed in the EEG, the mathematical descriptions of how propofol's EEG signatures relate to its mechanisms of action in neural circuits provide anesthesiologists with a neurophysiologically based approach to monitoring the brain states of patients receiving anesthesia care.


PMID: 24457211

DOI: 10.1016/j.conb.2013.12.011

Other references

Bowman, J.M.; Pollock, J.M., 1984: Reversal of Rh alloimmunization. Fact or fancy?. The Rh Laboratory could find no evidence that Rh immune globulin (RhIG) reduced the incidence of progression of Rh immunization in a clinical study of 36 weakly Rh-immunized women given 300 micrograms of RhIG at 6-week intervals during pregnancy a...

Lin, T-Yien.; Hwang, K.Pin.; Liu, C-Chuan.; Tang, R.Bin.; Lin, C.Yuang.; Gilbert, G.L.; Thapa, K.; Monegal, J.Sawchik.; Pirçon, J-Yves.; Van Dyke, M.K.; Liu, Y.Fang.; Huang, L-Min.; Hausdorff, W.P., 2013: Etiology of empyema thoracis and parapneumonic pleural effusion in Taiwanese children and adolescents younger than 18 years of age. We analyzed blood and pleural fluid samples from 89 Taiwanese children with empyema thoracis and parapneumonic pleural effusion. Streptococcus pneumoniae was the major pathogen, identified in 12 children by bacterial culture and 53 children by mol...

Wienecke, T.; Olesen, J.; Ashina, M., 2011: Prostaglandin I2 (epoprostenol) triggers migraine-like attacks in migraineurs. Prostacyclin [prostaglandin I(2) (PGI(2))] activates and sensitizes meningeal sensory afferents. In healthy subjects PGI(2) triggers headache in healthy subjects. However, the migraine-eliciting effect of PGI(2) has not been systematically studied...

Castro-Gago, M.; Lojo, S.; Del Rio, R.; Rodriguez, A.; Novo, I.; Rodriguez-Segade, S., 1986: The concentrations of xanthine and hypoxanthine in cerebrospinal fluid as therapeutic guides in hydrocephalus. Xanthine, hypoxanthine, and total oxypurine levels were determined in the cerebrospinal fluid of 18 hydrocephalic patients and 8 healthy controls by high-performance liquid chromatography (HPLC). Eight of the hydrocephalic patients were self-compe...

Dündar, Y.; Özatik, Y.; Özatik, O.; Ergin, V.; Önkol, T.; Menevşe, A.; Erol, K.; Sahin, M.Fethi., 2012: Synthesis and biological evaluation of the salicylamide and salicylic acid derivatives as anti-estrogen agents. Alkylphenols have xenoestrogenic activity, which mimic the action of physiological estrogens and these mimicking activities are mainly mediated by nongenomic pathway. Nongenomic pathway plays a pivotal role in breast, endometrial and ovarian cance...

White, F., 1976: Managing a country park. An account is given of the management of the Wirral country park which is able to provide facilities for conflicting recreational interests such as walkers and riders, fishermen and naturalists etc.

Rosene, Wjr, 1979: Managing wildlife on hunting plantations. Annual forestry symposium: 8th) 83-87

Farr, R.; Dickinson, W., 1961: The transfer of antibody producing capacity from intestinal to other lymphatic tissue. FED PROC 20(1 Pt 1): 25

Siddorn James P.; Cruden Alexander R., 2000: The Giant-Con gold deposits; evidence for a once linked Archean lode-gold deposit. Abstract Volume (Geological Association of Canada) 25: (unpaginated

Yamamoto, Y., 1969: Modification of metabolic pattern by variation of nadp level vigna sesquipedalis d enz dehydrogenase inst auto radiography. Plant Physiology (Rockville) 44(3): 407-412