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Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

, : Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants. Aging 3(2): 125-147

Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability to produce free-radical chain reactions. For this study, fatty-acid profiles were compared across a panel of C. elegans mutants that span a tenfold range of longevities in a uniform genetic background. Two lipid structural properties correlated extremely well with lifespan in these worms: fatty-acid chain length and susceptibility to oxidation both decreased sharply in the longest-lived mutants (affecting the insulinlike-signaling pathway). This suggested a functional model in which longevity benefits from a reduction in lipid peroxidation substrates, offset by a coordinate decline in fatty-acid chain length to maintain membrane fluidity. This model was tested by disrupting the underlying steps in lipid biosynthesis, using RNAi knockdown to deplete transcripts of genes involved in fatty-acid metabolism. These interventions produced effects on longevity that were fully consistent with the functions and abundances of their products. Most knockdowns also produced concordant effects on survival of hydrogen peroxide stress, which can trigger lipoperoxide chain reactions.


PMID: 21386131

DOI: 10.18632/aging.100275

Other references

Stelzer, K.J.; Gordon, M.A., 1988: Interactions of pyrethroids with gramicidin-containing liposomal membranes. Fluorescence steady-state anisotropy and phase-modulation lifetime techniques have been utilized to study the interactions of pyrethroid compounds with fluid-phase phosphatidylcholine membranes containing the polypeptide gramicidin. This polypepti...

Raymond Percy Edward; Narraway J.E., 1910: Notes on Ordovician trilobites; III, Asaphidae from the Lowville and Black River. Annals of Carnegie Museum: 46-59. 1910.

Szumińska-Napiontek, E.; Bortkiewicz, E., 1987: A form of acute glomerulonephritis with few symptoms. Polski Tygodnik Lekarski 42(47): 1483-1484

Brouwer J.; Van Leeuwen Herberts G.H.H.M.; Otting Van M.J., 1985: Estimation of lysozyme by enzyme immunoassay. Peeters, H (Ed ) Protides Of The Biological Fluids; Proceedings Of The Colloquium, Vol 32 Immunoglobulins, Tumor Markers And Targeting Advances in Separation Of Protides; Brussels, Belgium, 1984 Xxxv+1202p Pergamon Press: Oxford, England; New York, N Y , Usa Illus 403-406

Chen, P-Shih.; Tsai, F.Ta.; Lin, C.Kun.; Yang, C-Yuh.; Chan, C-Chuan.; Young, C-Yuan.; Lee, C-Hung., 2010: Ambient influenza and avian influenza virus during dust storm days and background days. The spread of influenza and highly pathogenic avian influenza (H5N1) presents a significant threat to human health. Avian influenza outbreaks in downwind areas of Asian dust storms (ADS) suggest that viruses might be transported by dust storms. We...

Maeda, T.; Tanaka, Y.; Takemoto, N.; Hamamoto, N.; Inui, M., 2015: RNase III mediated cleavage of the coding region of mraZ mRNA is required for efficient cell division in Corynebacterium glutamicum. The Corynebacterium glutamicum R cgR_1959 gene encodes an endoribonuclease of the RNase III family. Deletion mutant of cgR_1959 (Δrnc mutant) showed an elongated cell shape, and presence of several lines on the cell surface, indicating a required...

McKinlay, R.G., 1990: Pest management in vegetable brassicas without insecticides. A poster presented at the conference 'Crop protection in organic and low input agriculture', held at Churchill College, Cambridge, UK, on 4-6 September, 1990. A lightweight, transparent fabric cover ('floating mulch') was place...

Robert, N.J.; Goss, P.E.; Ingle, J.N.; Tu, D.; Shepherd, L.; Palmer, M.; Pater, J., 2016: Updated analysis of NCIC CTG MA.17 (letrozole vs. placebo to letrozole vs placebo) post unblinding. NlmCategory="UNASSIGNED">550 Background: 5187 postmenopausal women were originally randomized to NCIC CTG MA.17 to receive letrozole (LET) or placebo (PLAC) after 5 years of tamoxifen. The hazard ratio (HR) for disease-free survival (...

Dyatlov, V.A.; Lawrence, D.A.; Carpenter, D.O., 1996: Vitamin E enhances Ca-2+-mediated vulnerability of cerebellar granule cells to ischemia. Society for Neuroscience Abstracts 22(1-3): 1431

Ghusn, H.F.; Teasdale, T.A.; Jordan, D., 1997: Continuity of do-not resuscitate orders between hospital and nursing home settings. To determine the relationship between interinstitutional communication and continuity of advance directives from hospital to nursing home (NH) settings. Retrospective chart review of discharges to hospital affiliated or community NHs. Teaching Vet...