+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma

, : Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. American Journal of Surgical Pathology 33(4): 496-504

Microglandular adenosis (MGA) is an uncommon, benign breast lesion that is characterized by a proliferation of small uniform, round glands lined by a single layer of epithelial cells around open lumina with haphazard infiltrative growth in fibrous and fatty breast tissue. Although MGA usually has an indolent course, there is morphologic evidence that MGA can be a precursor for the development of intraductal and invasive ductal carcinoma. To investigate the possibility of such a transition, we studied 17 cases of MGA or atypical MGA some of which had given rise to carcinoma in situ (CIS) and/or invasive ductal carcinoma using the reticulin stain, immunohistochemistry (S-100, p63, Ki-67, and p53), and a molecular approach involving microdissection and high-resolution comparative genomic hybridization and MYC chromogenic in situ hybridization. MGA and carcinomas arising from MGA were typically negative for p63 and positive for S-100 and Ki-67 and occasionally positive for p53. High-resolution comparative genomic hybridization identified recurrent gains and losses in MGA (2q+, 5q-, 8q+, and 14q-) and atypical MGA (1q+, 5q-, 8q+, 14q-, and 15q-). Some examples of MGA and carcinomas arising from MGA harbored few gross chromosomal abnormalities whereas others had considerable genetic instability with widespread aberrations affecting numerous chromosomal arms. Such widespread genetic changes, together with recurrent loss of 5q and gain of 8q were reminiscent of those reported specifically for basal-like, estrogen receptor-negative, and BRCA1-associated breast tumors. Concordant genetic alterations were identified between MGA, atypical MGA, and higher risk lesions (CIS and invasive ductal carcinoma) and in some cases there was an accumulation of genetic alterations as cases "progressed" from MGA to atypical MGA, CIS, and invasive ductal carcinoma. The molecular data suggests that MGA, atypical MGA, and carcinoma arising in MGA in a single case were clonally related. This result implicates MGA as a nonobligate precursor for the development of intraductal and invasive ductal carcinoma.


PMID: 19047897

DOI: 10.1097/PAS.0b013e31818af361

Other references

Zeng ShiMai, 1996: Study on the method of estimation of relative parasitic fitness of plant pathogenic fungi, exemplified with Puccinia striiformis West. Relative apparent infection rate (RAR) was suggested as a suitable estimate of relative parasitic fitness of a plant pathogen in this study of the population dynamics of cultivar/race interactions of wheat yellow rust. RAR can be estimated either...

Mendez, A.; Seikaly, H.; Ansari, K.; Murphy, R.; Cote, D., 2014: High definition video teaching module for learning neck dissection. Video teaching modules are proven effective tools for enhancing student competencies and technical skills in the operating room. Integration into post-graduate surgical curricula, however, continues to pose a challenge in modern surgical education...

Duszyk M.; French A.S.; Man S.F.P., 1992: Apical membrane surface charge of mdck cells. Biophysical Journal 61(2 PART 2): A536

Durairaj, S.; Keenan, N.; Hyslop, A.; Groves, M.J.; Bowen, D.T.; Tauro, S., 2013: Azacitidine-eligibility in higher-risk myelodysplastic syndromes and chronic myelomonocytic leukaemia: a registry-based study. British Journal of Haematology 161(2): 280-282

Sorenson, E.J.; Stalker, A.P.; Kurland, L.T.; Windebank, A.J., 2002: Amyotrophic lateral sclerosis in Olmsted County, Minnesota, 1925 to 1998. The authors sought to determine trends in the incidence of ALS in Olmsted County from 1925 to 1998. Seventy-seven cases of ALS were identified during the period studied. The incidence rate remained stable at 1.7 cases per 100,000 people per year....

Oden, T.C., 1973: Populist psychotherapy. Journal of Religion and Health 12(4): 386-394

Kuo H P.; Rogers D.F.; Barnes P.J.; Mcdonald Gibson W.J.; Hall R.L., 1992: Tachykinin stimulation of secretory event rate in guinea pig tracheal epithelial cells and inhibition by an nk 1 antagonist. American Review of Respiratory Disease 145(4 PART 2): A369

Sty, J.R.; Babbitt, D.P.; Starshak, R.J., 1978: Bone scintigraphy demonstrating Engelmann's disease. Clinical Nuclear Medicine 3(2): 69-70

Chen, S.; Zhou, D.; Okubo, T.; Kao, Y.C.; Yang, C., 2000: Breast tumor aromatase: functional role and transcriptional regulation. Aromatase has been shown to be expressed at a higher level in human breast cancer tissue than in normal breast tissue, by means of enzyme activity measurement, immunocytochemistry, and RT-PCR analysis. Cell culture including MCF-7 breast cancer ce...

Osborne, M.; Glynne Jones, R.; Galbraith, S.; Burcombe, R.; Makris, A., 1999: Squamous cell carcinoma antigen as a marker of epidermoid carcinoma of the anal canal. British Journal of Cancer 80(SUPPL 2): 58, July