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Molecular insight in the multifunctional activities of Withaferin A


, : Molecular insight in the multifunctional activities of Withaferin A. Biochemical Pharmacology 84(10): 1282-1291

Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even today the popularity of medicinal herbs is still growing like in traditional medicines such as the Indian medicine, Ayurveda. One of the Ayurvedic medicinal plants is Withania somnifera Dunal, of which the important constituents are the withanolides. Among them, Withaferin A is one of the most bioactive compounds, exerting anti-inflammatory, pro-apoptotic but also anti-invasive and anti-angiogenic effects. In the context of modern pharmacology, a better insight in the underlying mechanism of the broad range of bioactivities exerted by Withaferin A is compulsory. Therefore, a lot of effort was made to explore the intracellular effects of Withaferin A and to characterize its target proteins. This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A.

US$19.90

PMID: 22981382

DOI: 10.1016/j.bcp.2012.08.027


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Weingärtner, O.; Hasan, T.; Böhm, M., 2005: Pathophysiology and differential diagnosis of dyspnea. Dyspnea is the sensation of breathlessness, which is one of a few symptoms described as frightening and alarming. There are different hypotheses of pathophysiological mechanisms explaining a multitude of symptoms described by patients. Objective c...

Chen, D.X.; Zheng, D.S.; Zhang, S.H.; Wu, Y.X.; Bao, S.H.; Xia, L.L., 1991: Factors influencing ablation of atherosclerotic plaque with argon laser. The ablative effect of argon laser delivered fibreoptically in vitro on 234 segments of atherosclerotic human aorta was studied. The variables such as energy density, type of atheroma and immersion media were included, and all irradiated specimens...

Rohrer, B.; Pinto, F.R.; Hulse, K.E.; Lohr, H.R.; Zhang, L.; Almeida, J.S., 2004: Multidestructive pathways triggered in photoreceptor cell death of the rd mouse as determined through gene expression profiling. In the rd/rd mouse, photoreceptor degeneration is due to a mutation of the rod-specific enzyme cGMP phosphodiesterase, resulting in permanently opened cGMP-gated cation channels in the rod outer segment membrane that allow Na+ and Ca2+ ions to ent...

Combes, A.; E.A.dellaoui, Sïda.; Vial, Jérome.; Lagrange, E.; Pichon, Vérie., 2015: Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-L-alanine in brain tissues. The cyanotoxin β-methylamino-L-alanine (BMAA) has received renewed attention as an environmental risk factor for sporadic cases of amyotrophic lateral sclerosis (ALS) (Nunn et al., Brain Res 410:375-379, 1987). The aim of the present study was to...

Russo, S.Giuseppe.; Bräuer, A., 2013: Difficult extubation in a patient with terminal ischemic heart failure and an accompanying difficult airway. Journal of Cardiothoracic and Vascular Anesthesia 26(6): 1067-1068

Latorre-Estivalis, J.Manuel.; de Oliveira, E.Soares.; Beiral Esteves, B.; Santos Guimarães, Lícia.; Neves Ramos, M.; Lorenzo, M.Gustavo., 2015: Patterns of expression of odorant receptor genes in a Chagas disease vector. Rhodnius prolixus is a triatomine bug acting as a relevant vector of Chagas disease for which the genome sequence has been recently made available. Based on this information, a set of olfactory (ORs) and ionotropic receptor (IRs) genes potentially...

Baubion N.; Atal Cohen L.; Zannier Marzari D.; Adams C.; Mouchet B.; Vacheron A., 1985: Contribution of echocardiography in the etiological diagnosis of syncopes in the adult. Kaplan, G Entretiens De Bichat, Medecine (Continuing Education Courses Of Bichat, Medicine); Meeting, Sept 30-Oct 3, 356p Expansion Scientifique Francaise: Paris, France Illus 44-47

Otto, C.N.lsson, L., 1981: Why do beech and oak trees retain leaves until spring?. Oikos 37(3): 389-390

Dahchour, A.; Bitton, G.; Coste, C.M.; Bastide, J., 1986: Degradation of the herbicide propanil in distilled water. HPLC analysis of hexane extracts of propanil, which had been added to distilled water at 50 p.p.m. and maintained at 28 degrees C, showed that following a lag phase of 48 h, the herbicide was completely degraded within 120 h to 3,4-dichloroaniline...

Cerny, A.; Merino, R.; Makino, M.; Waldvogel, F.A.; Morse, H.C.; Izui, S., 1991: Protective effect of cyclosporin A on immune abnormalities observed in the murine acquired immunodeficiency syndrome. The murine leukemia viruses (MuLV) designated LP-BM5 induce an immunodeficiency disease in susceptible strains of mice with many features in common to human acquired immunodeficiency syndrome (AIDS), including lymphadenopathy and profound immunode...