geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging


, : Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging. Expert Reviews in Molecular Medicine 11: E25-E25

Infiltration of T cells is a key step in the pathogenesis of the inflammatory skin diseases atopic dermatitis, allergic contact dermatitis and psoriasis. Understanding the mechanisms of T cell recruitment to the skin is therefore of fundamental importance for the discovery and application of novel therapies for these conditions. Studies of both clinical samples and experimental models of skin inflammation have implicated specific adhesion molecules and chemokines in lymphocyte recruitment. In particular, recent studies using advanced in vivo imaging techniques have greatly increased our understanding of the kinetics and molecular basis of this process. In this review, we summarise the current understanding of the cellular immunology of antigen-driven dermal inflammation and the roles of adhesion molecules and chemokines. We focus on results obtained using intravital microscopy to examine the dermal microvasculature and interstitium to determine the mechanisms of T cell recruitment and migration in experimental models of T-cell-mediated skin inflammation.

US$19.90

PMID: 19691914

DOI: 10.1017/S146239940900115X


Other references

Miles, J.E., 2015: Factors Associated with Delayed Ejection in Mishaps Between 1993 and 2013. The purpose of this investigation was to identify factors associated with Air Force aviators delaying ejection during in-flight emergencies. The investigator reviewed all reports within the Air Force Safety Automated System describing mishaps that...

Cagnoni, S.; Caramella, D.; D.D.minicis, R.; Valli, G., 1992: Neural network synthesis of spin echo multiecho sequences. Spin echo multiecho sequences are not frequently used in clinical practice, because they allow the observation of one single slice, imaged at different echo times, for each acquisition. To limit examination time, multislice sequences that include...

Godeny, E., 1953: Time interval between deciduous teeth and the eruption of permanent teeth. Fogorvosi Szemle 46(6): 164-169

Weinberg, B.J., 1958: Antrenyl in the treatment of gastrointestinal diseases. American Journal of Gastroenterology 30(6): 630-633

Hudgins, P.M.; Stubbins, J.F., 1969: Pharmacologic evaluation of a new series of cholinergic antagonists containing an agonist moiety. Journal of Pharmacology and Experimental Therapeutics 166(2): 237-242

Dimitrievics, G.; Kovacs, P., 1976: Economic aspects of the plant protection activities of agrochemical centres. Model calculations, statistics and published material are analyzed to determine whether agro-chemical centres are economical from the plant protection point of view. Because of unresolved storage problems, the centres are already needed, and in th...

Cizman, M.; Pokorn, M.; Gubina, M.; Paragi, M., 2001: Incidence and evolution of antibiotic susceptibility of invasive Streptococcus pneumoniae in children and adults in Slovenia in 1999. International Journal of Antimicrobial Agents 17(Supplement 1): S126-S127, June

Snijders, A.P.L.; Walther, J.; Peter, S.; Kinnman, I.; de Vos, M.G.J.; van de Werken, H.J.G.; Brouns, S.J.J.; van der Oost, J.; Wright, P.C., 2006: Reconstruction of central carbon metabolism in Sulfolobus solfataricus using a two-dimensional gel electrophoresis map, stable isotope labelling and DNA microarray analysis. In the last decade, an increasing number of sequenced archaeal genomes have become available, opening up the possibility for functional genomic analyses. Here, we reconstructed the central carbon metabolism in the hyperthermophilic crenarchaeon Su...

Vostokova, K.K.; Andreeva, M.I., 1964: Diagnosis Of Quartan Malaria. Meditsinskaia Parazitologiia i Parazitarnye Bolezni 33: 724-726

Anonymous, 2011: Critical and complex role of NMDA receptors in long-term depression at CA3-CA1 synapses in the developing hippocampus. In the developing brain synaptogenesis is accompanied by elimination of synapses possibly initiated by activity-dependent synaptic plasticity such as long-term depression (LTD). Experiments using 2 nd postnatal week hippocampal CA3-CA1 synapses ha...