+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Monitoring the inflammatory potential of exhaust particles from passenger cars in mice

, : Monitoring the inflammatory potential of exhaust particles from passenger cars in mice. Inhalation Toxicology 22 Suppl 2: 59-69

This study presents different research techniques linked together to improve our understanding of the particulate matter (PM) impacts on health. PM samples from the exhaust of different vehicles were collected by a versatile aerosol concentration enrichment system (VACES). Waterborne PM samples were collected with this technique, thus retaining the original physicochemical characteristics of aerosol particles. PM samples originated from a gasoline Euro 3 car and two diesel cars complying with the Euro 2 and Euro 4 standards, respectively. The Euro 2 diesel car operated consecutively on fossil diesel and biodiesel. The Euro 4 car was also retrofitted with a diesel particle filter. In total, five vehicle configurations and an equal number of samples were examined. Each sample was intratracheally instilled to 10 mice at two different dose levels (50 and 100 μL). The mice were analyzed 24 h after instillation for acute lung inflammation by bronchoalveolar lavage and also for hematological changes. Results show that a moderate but still significant inflammatory response is induced by PM samples, depending on the vehicle. Several organic and inorganic species, including benz(a)anthracene, chrysene, Mn, Fe, Cu, and heavy polycyclic aromatic hydrocarbons (PAHs), as well as the reactive oxygen species content of the PM suspensions are correlated to the observed responses. The study develops conceptual dose-response functions for the different vehicle configurations. These demonstrate that inflammatory response is not directly proportional to the mass dose level of the administered PM and that the relative toxicity potency depends on the dosage level.


PMID: 21029033

DOI: 10.3109/08958378.2010.519408

Other references

Fagan, A.M.; Holtzman, D.M.; Munson, G.; Mathur, T.; Schneider, D.; Chang, L.K.; Getz, G.S.; Reardon, C.A.; Lukens, J.; Shah, J.A.; LaDu, M.J., 1999: Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. Composition of central nervous system lipoproteins affects the metabolism of lipoprotein constituents within the brain. The epsilon4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease via an unknown mechanism(s). As gl...

Ross, E.R.; Cole, W.G., 1985: Treatment of subacute osteomyelitis in childhood. A protocol for the treatment of subacute haematogenous osteomyelitis has been used and evaluated in 71 children. A group of 26 children with a radiologically "aggressive" lesion had biopsy followed by antibiotics and immobilisation for s...

Hightower, J., 1975: The industrialization of food. People's Land: a Reader on Land Reform in the United States P Barnes ed: 1-85

Guo Yu.; Zhou Bingsheng.; S.J.ngming.; Chang Xiaotian.; Gao Cuiqin., 1992: Ultrastructural effects of cadmium sulphide and titanium dioxide upon Tetrahymena pyriformis. Journal of Wuhan University (Natural Science Edition): 3: 91-96

Mcdade C.; Young A.G., 1973: Failure of electro convulsive shock to produce amnesia in a noncontingent situation. Bulletin of the Psychonomic Society 2(5B): 350

García-Borbolla, M.; García-Borbolla, R.; Valenzuela, L.F.; Trujillo, F., 2007: Ventricular tachycardia induced by exercise testing in a patient with Brugada syndrome. Revista Espanola de Cardiologia 60(9): 993-994

Pokrovskii A.V.; Kovaneva P.A.; Zingerman L.S.; Gashtov A.Kh; Tsitsuashvili G.A., 1979: Indications for surgical treatment of cerebro vascular insufficiency in patients with occlusive lesions of the brachiocephalic vessels. Soviet Neurology & Psychiatry 12(2): 20-37

Apikoglu, M.; Bulucu, F.; Demirbas, S.; Ay, S.Ahmet.; Karaman, M.; Altun, B.; Balta, S.; Gokce, G.; Demirkol, S.; Yaman, H.; Saglam, K., 2014: The relationship between microalbuminuria, left ventricular hypertrophy, retinopathy, and sex hormone status in newly diagnosed hypertensive women. An increased incidence of hypertension (HT) in postmenopausal female population has been shown in previous studies and this has been ascribed to an association with altered status of estrogen (E2) and other female sex hormones. Hypertension is ass...

Gaio, G.; Santoro, G.; Iacono, C.; Carrozza, M.; Cappelli Bigazzi, M.; Giovanna Russo, M.; Calabrò, R., 2006: Non-surgical treatment of ruptured sinus of Valsalva aneurysm. International Journal of Cardiology 113(2): E44-E45

Blevins, J.E.; Eakin, T.J.; Murphy, J.A.; Schwartz, M.W.; Baskin, D.G., 2003: Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. The integration of 'long-term' adiposity signaling with the 'short-term' meal-related signal cholecystokinin (CCK) is proposed to involve descending hypothalamic projections to areas of the caudal brainstem (CBS) that regulate...