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Morphologic changes in the tumor and liver in mice with transplanted RLS40 lymphosarcoma during increase of its drug resistance

, : Morphologic changes in the tumor and liver in mice with transplanted RLS40 lymphosarcoma during increase of its drug resistance. Bulletin of Experimental Biology and Medicine 149(2): 258-261

The progress of drug resistance of RLS(40) resistant lymphosarcoma and specific features of toxic lesions in the liver in polychemotherapy were studied. After intramuscular injection of tumor cells, the mice received a course of polychemotherapy. The tumor material was then collected and transplanted to intact animals, after which polychemotherapy was carried out. A total of 4 passages of tumor cells and 4 polychemotherapy courses were carried out. The expression of mdr1b, bcl-2, and p53 genes in tumor cells increased by 1.3, 2.3, and 1.6 times after 4 courses of polychemotherapy in comparison with intact tumor. Volume density of apoptoses in tumor tissue after 4 polychemotherapy courses decreased 1.7 times compared to that after single course. The increase in cytostatic load was associated with aggravation of destructive changes in the liver: the volume density of necroses in the liver increased 1.3 times after 4 passages of the tumor.


PMID: 21113505

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Bagg, J.; Poxton, I.R.; Weir, D.M., 1981: The isolation of a lectin-like molecule from Corynebacterium parvum (NCTC 10390). A mannose specific lectin has been isolated by affinity chromatography from the cell wall of C. parvum. Polyacrylamide gel electrophoresis indicates that the lectin molecules lie in the molecular weight range 57,000--72,000. It appears that C. par...

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Mukamal, K.J.; Nesto, R.W.; Cohen, M.C.; Muller, J.E.; Maclure, M.; Sherwood, J.B.; Mittleman, M.A., 2001: Diabetes and long-term survival after acute myocardial infarction Comparability of risk with prior myocardial infarction. Circulation 103(9): 1349, March 6

Belkacemi, A.; Ramassamy, C., 2016: Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State. In Alzheimer's disease (AD) and in mild cognitive impairment (MCI) patients, by-products of lipid peroxidation such as acrolein accumulated in vulnerable regions of the brain. We have previously shown that acrolein is a highly reactive and ne...

Lafortune S.H.; Ireland D.J.; Jell R.M., 1987: Evidence for otolith coupling to velocity storage in human optokinetic afternystagmus. Society for Neuroscience Abstracts 13(2): 1314

Serrano, J.A.; Mejia, M.A.; Diaz Corrales, F.; Uzcategui Negron, M.; Saad, C.; Couble, A.; Casoli, E.; Boiron, P.; Garcia, E., 2001: Rapid identification by PCR of two strains of Nocardia brasiliensis isolated from an actinomycetoma case. A case of a 20-year-old white male rural tractor driver from Venezuela with a 5-year history of cutaneous infection in the left hip and superior external left thigh is presented [date not given]. It consisted of a non-painful tumour with an irregu...

Floman, Y.; Eyre, D.R.; Glimcher, M.J., 1980: Induction of osteoarthrosis in the rabbit knee joint: biochemical studies on the articular cartilage. Measurements of uptake in vivo of 3H-proline into 3H-hydroxyproline demonstrate that cartilage surfaces in rabbit knees with surgically induced osteoarthrosis (up to 3 months after operation) incorporated 2 to 5 times more activity into collagen t...

Stanley M.W., 1991: Diagnosis of primary and secondary pulmonary malignancies. Stanley, M W , M J Henry-Stanley And C Iber Bronchoalveolar Lavage: Cytology And Clinical Applications Xi+240p Igaku-Shoin Medical Publishers, Inc : New York, New York, Usa; Bunkyo-Ku, Tokyo, Japan Illus 159-194

Paerregaard, P., 1957: A new method for quantitative determination of small amounts of morphine in human urine. Urine is heated with acid to liberate bound morphine, and extracted with chloroform isopropanol. Morphine is isolated by descending paper chromatography and determined polarographically as 2-nitroso-morphine. On 5 ml urine, 1-10 [mu]g morphine/ml...

Sanders, R.D.; Maze, M., 2009: Does correcting the numbers improve long-term outcome?. Anesthesiology 111(3): 475-477