geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging


, : Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging. Dalton Transactions 43(42): 15841-15850

The development of theranostic mesoporous hollow silica nanospheres having therapeutic and diagnostic functions has been achieved. The exterior surface of the hollow mesoporous silica nanosphere was selectively acid functionalized and utilised to conjugate the anticancer drug cisplatin, the marker molecule folic acid (FA), and rhodamine isothiocyanate (RITC), whereas the interior space was utilised to encapsulate superparamagnetic CoFe2O4 nanoparticles as well as the hydrophobic anticancer drug pemetrexed. The hydrodynamic size of the synthesized multidrug loaded hollow particles is 130 nm in physiological pH and it is consistent over a long period. To the best of our knowledge this is the first report on fluorescent magnetic hollow spheres loaded with multiple therapeutic cargoes as well as a magnetic resonance imaging (MRI) contrast agent. The as prepared hollow spheres are biocompatible. The internalization efficiency of the drug loaded particle has been evaluated on folate receptor overexpressed (FR+ve) HeLa, FR-ve HaCat and 3T3 cells. These drug loaded nanospheres exhibit enhanced cytotoxicity as compared to individual drugs. Such a strategy in the simultaneous administration of pemetrexed and platin drugs may open up opportunities for the treatment of lung cancer at its early stage.

US$19.90

PMID: 25224136

DOI: 10.1039/c4dt02144d


Other references

Haslam, I.S.; Wright, J.A.; O'Reilly, D.A.; Sherlock, D.J.; Coleman, T.; Simmons, N.L., 2012: Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2). Intestinal secretory movement of the fluoroquinolone antibiotic, ciprofloxacin, may limit its oral bioavailability. Active ATP-binding cassette (ABC) transporters such as breast cancer resistance protein (BCRP) have been implicated in ciprofloxaci...

Jones, C., 2003: Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Primary infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system, upper respiratory tract, and gastrointestinal tract. Recurrent ocular shedding leads to corneal scarring that can pr...

Cezard J.P.; Lambert N.; Bingen E.; Marinier E.; Navarro J., 1985: Fecal flora modification during constant rate enteral nutrition with an elemental diet in infants. Desjeux, J -F And R Ducluzeau (Ed ) Colloque Inserm (Institut National De La Sante Et De La Recherche Medicale), Vol 121 La Diarrhee Du Jeune (National Institute Of Health And Medical Research Colloquium, Vol 121 Diarrhea in The Young; Meeting, Versailles, France, Mar 13-15, 1984) 507p Editions Inserm: Paris, France Illus Paper 109-114, 1984

Mukhin P., 1995: The metamorphosed turbidites of Andros Island and their application (Greece). Annual Meeting Israel Geological Society: Pages 79. 1995.

Bonora, M., 1980: How to manage the reproduction and replacement. Rivista di coniglicoltura 17(2): 29-30

Nakao H.; Shinoda S.; Yamamoto S., 1990: Purification and properties of carboxynorspermidine decarboxylase a novel enzyme involved in norspermidine biosynthesis from vibrio alginolyticus. A novel enzyme which catalyses the decarboxylation of carboxynorspermidine [H2N(CH2)3NHCH2CH2-CH(NH2)COOH] to yield norspermidine [H2N(CH2)3NH(CH2)3NH2], one of the unusual polyamines, was purified to apparent homogeneity (3100-fold) from cells of...

Reitter, E., 1891: Erster Beitrag zur Coleopteren-Fauna. von Europa und den angrenzenden Landern. Wiener Entomologische Zeitung, X 246-249

Duggirala, S.M.; Hughes, P.M.; Krishnamoorthy, R.; Mitra, A.K., 1996: Intravitreal kinetics of acycloguanosine analogs and their prodrugs using microdialysis. Pharmaceutical Research (New York) 13(9 SUPPL ): S466

Pellegrini, N.B.aca, G., 1974: Anatomo-histopathological reliefs in spontaneous and experimental pathology in acute dogs poisoning. Annali ub 1974), 26 323-364

Koul, O.; Tikku, K.; Saxena, B.P., 1987: Ovarian dysfunction and morphogenetic defects induced by Origanum vulgare L oil in the red cotton bugs. The use of essential oils of plant origin in insect control has recently been reviewed. There are some reports pertaining to the efficacy of essential oils to induce morphogenetic effects and gonadal disorders among a variety of insects. In view o...