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Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis

, : Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis. Asian Pacific Journal of Cancer Prevention 11(6): 1823-1826

Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL). We aimed to assess this possibility in Turkish patients. Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included. Flow cytometry and fluorescein-isothiocynate conjugated antibodies were used to determined surface antigens on blasts. Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant. Overall survival rates of myeloid antigen positive patients at 36, 60, and 72 months were 76%, 58%, and 48%, respectively, comparable to the corresponding 70%, 56%, and 46% in myeloid antigen negative patients (p >0.05). We did not find any association between myeloid antigen positivity and clinical and laboratory features of ALL.


PMID: 21338240

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