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Myeloid derived suppressor cells and their role in tolerance induction in cancer


, : Myeloid derived suppressor cells and their role in tolerance induction in cancer. Journal of Dermatological Science 59(1): 1-6

Myeloid derived suppressor cells (MDSCs) comprise a phenotypically heterogeneous population of cells, which can be found in tumor-bearing mice and in patients with cancer. MDSCs play a central role in the induction of peripheral tolerance. Together with regulatory T cells (Tregs) they promote an immunosuppressive environment in tumor-bearing hosts. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. In summary, MDSCs are a group of phenotypically heterogeneous cells of myeloid origin that have common biological activities. In this review, we discuss the definition of MDSCs, the proposed mechanisms of expansion and the recruitment and activation of MDSCs, as well as their biological activities in tumorbearing hosts to assess the potential therapeutic applications.

US$19.90

PMID: 20570112

DOI: 10.1016/j.jdermsci.2010.05.001


Other references

Siemiatycki, J.; Colle, E.; Campbell, S.; Dewar, R.A.; Belmonte, M.M., 1989: Case-control study of IDDM. Insulin-dependent diabetes mellitus (IDDM) may be caused by a combination of genetic predisposition and environmental insults. However, there are few solid leads concerning human diabetogenic environmental agents. A case-control study was carried...

Zhuravlev, I.V.; Aydinyan, T.G.; Davtyan, D.A.; Fisinin, V.I.; Avdonin, B.F., 1999: About feed consumption and metabolism of meat-type chicks during the period of neonatal growth. Feed and water consumption and growth rate of meat-type chicks have been investigated during the period of 7 days posthatching. It was shown that after depletion of residual yolk increase in relative feed and water consumption is slowed down and r...

Mcneal, B.; Stanley, C.; Espinoza, L.; Schipper, L., 1994: Nitrogen management for vegetables and citrus: some environmental considerations. Proceedings 3(53): 45-51

Mula, M.; Pini, S.; Calugi, S.; Preve, M.; Masini, M.; Giovannini, I.; Rucci, P.; Cassano, G.B., 2010: Distinguishing affective depersonalization from anhedonia in major depression and bipolar disorder. Affective depersonalization has received limited attention in the literature, although its conceptualization may have implications in terms of identification of clinical endophenotypes of mood disorders. Thus, this study aims to test the hypothesi...

Rozental, S.; de Carvalho, T.U.; de Souza, W., 1987: Influence of the endosymbiont on the interaction of Crithidia deanei with macrophages. Microscopia Electronica Y Biologia Celular 11(2): 167-177

Li, H.; Xi, Z.; Dai, X.; Wu, W.; Li, Y.; Liu, Y.; Zhang, H., 2017: CD147 and glioma: a meta-analysis. Gliomas are the most common primary brain tumors. This meta-analysis aimed to systematically evaluate the relationship between CD147 expression in tissues and the clinicopathological features of patients with glioma. We searched PubMed (1966-2016)...

Li, D-Jiang.; Bei, J-Xin.; Mai, S-Juan.; Xu, J-Fen.; Chen, L-Zhen.; Zhang, R-Hua.; Yu, X-Juan.; Hong, M-Huang.; Zeng, Y-Xin.; Kang, T., 2009: The dominance of China 1 in the spectrum of Epstein-Barr virus strains from Cantonese patients with nasopharyngeal carcinoma. Nasopharyngeal carcinoma is a disease with a remarkable geographic and ethnic distribution, and has a high incidence in southern China. Infection with Epstein-Barr virus (EBV) is an important contributing factor. The profile of EBV strains in Cant...

Furreg, Erich, 1931: Uber die Kutikula des Vo-geleies und einen Nachweis ihres Bildungsortes. The presence of a structureless membrane outside the calcareous shell layer of the bird's egg has long been established; there has been debate as to the region of its formation. In the eggs of the hen, guinea-fowl, turkey, and various pheasan...

Lykke, L., 1968: Duetrost i Nord-Trandelag. Sterna, 8: 95, 102

Sube Singh; Godara, A.K.; Hasija, R.C., 2004: Perception of extension personnel about economic aspects of sustainable dryland agriculture. This study was conducted in the Bhiwani district of Haryana state, India, which was selected purposively on the basis of maximum area under dryland agriculture. All four sub-divisions, viz., Bhiwani, Dadri, Loharu and Siwani, were selected to coll...