geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia


, : NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia. Clinical Journal of Pain 28(2): 101-107

Analyses of integrated data from 4 controlled postherpetic neuralgia studies evaluated the effect of NGX-4010, a capsaicin 8% patch, administered alone or together with systemic neuropathic pain medications. Patients recorded their “average pain for the past 24 hours” daily for 12 weeks using an 11-point Numeric Pain Rating Scale (NPRS). Efficacy assessment included the percentage NPRS score reduction from baseline during weeks 2 to 8 and 2 to 12, the proportion of patients responding during weeks 2 to 8 and 2 to 12 and the Patient Global Impression of Change (PGIC) at weeks 8 and 12. During the studies, 302 NGX-4010 and 250 control (capsaicin, 0.04% wt/wt) patients were using at least 1 systemic neuropathic pain medication; 295 NGX-4010 and 280 control patients were not. During weeks 2 to 8, NGX-4010 patients reported greater reductions in NPRS scores compared with control both in patients using systemic neuropathic pain medications (26.1% vs. 18.1%, P=0.0011) and in patients not using these medications (36.5% vs. 26.2%, P=0.0002). Patients not using systemic neuropathic pain medications reported a greater reduction in pain compared with patients using these medications in both, NGX-4010 and control groups, resulting in comparable treatment differences between NGX-4010 and control regardless of systemic neuropathic pain medication use. Similar results were seen during weeks 2 to 12, for the responder and PGIC analyses. Transient, capsaicin-related application site reactions were the most common adverse events and not affected by systemic neuropathic pain medication use. A single 60-minute NGX-4010 treatment reduces PHN for up to 12 weeks regardless of concomitant systemic neuropathic pain medication use.

US$19.90

PMID: 21753727

DOI: 10.1097/AJP.0b013e318227403d


Other references

Bersamin, M.; Paschall, M.J.; Fisher, D.A., 2017: Oregon School-Based Health Centers and Sexual and Contraceptive Behaviors Among Adolescents. This study investigated the association between school-based health centers (SBHCs) and sexual behavior and contraceptive use among 11th graders. The sample included 134 high schools (27 schools with SBHCs) and 11,840 students who participated in...

Pereira, A.Lenho.de.Figueiredo.; Moura, M.Aparecida.Vasconcelos., 2010: Hegemony and counter-hegemony in the process of implementing the Casa de Parto Birth Center in Rio de Janeiro. This study addressed the process of implementing the first Casa de Parto Birth Center in the Unified Health System in the city of Rio de Janeiro. The purpose of this qualitative study was to identify the determinants of the process of implementing...

Jana, S.; Pande, S.; Panigrahi, S.; Praharaj, S.; Basu, S.; Pal, A.; Pal, T., 2006: Exploitation of electrostatic field force for immobilization and catalytic reduction of o-nitrobenzoic acid to anthranilic acid on resin-bound silver nanocomposites. A new solid-phase catalyst has been designed and reported here for the catalytic reduction of o-nitrobenzoic acid to anthranilic acid. Electrostatic field force helps immobilization, in turn deposition of silver nanoparticles onto solid resin surf...

Norbert Clauer; James R.O.Neil; José Honnorez; Martine Buatier, 2011: 87Sr/86Sr and 18O/16O ratios of clays from a hydrothermal area near the Galapagos rift as records of origin, crystallization temperature and fluid composition. Strontium and O isotope compositions of green clay minerals from sediment cores of three boreholes drilled into (sites 424A and 59B) and close to a hydrothermal mound (site 424B) near the Galapagos Spreading Center (DSDP Legs 54 and 7) were determ...

Lubritz D.L.; Humes P.E.; Aguel C.F.; Morrison D.G., 1987: Genetic and environmental factors influencing the growth patterns of upgraded chianina cows. Journal of Animal Science 65(SUPPL 1): 9

Musyafa,, 2006: Effects of artificial acid rain on soil macroinvertebrate colonization in oak (Quercus serrata) and Japanese cedar (Cryptomeria japonica) Stands. To clarify the effects of artificial acid rain on soil macroinvertebrates, a field study was done in an oak and a japanese cedar stands in Tanashi experiment station, The University of Tokyo from 1996 to 1998. 135 ceramic pots filled with black so...

Mukhopadhyay, D.Kanti.; Mukhopadhyay, S.; Biswas, A.Bandhu., 2011: Enduring starvation in silent population: a study on prevalence and factors contributing to household food security in the tribal population in Bankura, West Bengal. Strengthening food security enhancement intervention should be based on the assessment of household food security and its correlates. The objective was to find out the prevalence and factors contributing to household food security in a tribal popu...

Chanfray; Pirner, 1987: Nuclear binding and quark confinement. Physical Review. C, Nuclear Physics 35(2): 760-773

Wassmann, R., 1989: Erfolgreiche Drittbrut beim Teichrohrsanger (Acrocephalus scirpaceus). Ornithologische Mitteilungen, 4112: 306

Savacool, J.W., 1986: Philadelphia and the White Plague. Transactions & Studies of the College of Physicians of Philadelphia 8(3): 147-181